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Summary for Patent: 4,701,460
|Title:||Long duration neuromuscular blocking agents|
|Abstract:||Long duration muscle relaxant compound of formula (I) ##STR1## and its use in producing muscle relaxation in mammals including man.|
|Inventor(s):||El-Sayad; Hassan A. (Chapel Hill, NC), Swaringen, Jr.; Roy A. (Durham, NC), Yeowell; David A. (Chapel Hill, NC)|
|Assignee:||Burroughs Wellcome Co. (Research Triangle Park, NC)|
1. A compound of the formula ##STR3## wherein X is a pharmaceutically acceptable anion.
2. A mixture comprising the mixture of the racemic (dl) pair ad the meso-isomer of the compound of the formula ##STR4##
3. A pharmaceutically acceptable salt comprising the cation trans-; trans-2,2,'-(dimethylenebis;(carbonyloxytrimethylene) bis(1,2,3,4-tetrahydro-6,7,8-trimethoxy-2-methyl-1(3,4,5-trimethxoybenzyl) isoquinolinium) and a pharmaceutically acceptable anion.
4. The compound of claim 3 in which the compound is the racemic dl pair of the meso isomer.
5. The compound of claim 2 in which X is chlorine.
6. The compound of claim 2 in which the cation comprises approximately a 1:1 mixture of the racemic (dl) pair and the meso isomer.
7. The compound of claim 6 in which X is chlorine.
8. trans,trans-2,2'-(Dimethylenebis(carbonyloxytrimethylene)) bis(1,2,3,4-tetrahydro-6,7,8-trimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl )isoquinolinium)dichloride.
9. A pharmaceutical composition comprising the compound of claim 8 in a pharmaceutically acceptable carrier therefor.
10. A method of producing a long duration of muscle relaxation in a mammal which comprises parenterally adminstering an effective muscle relaxant amount of the compound of claim 3, to said mammal.
11. A method of producing a long duration of muscle relation in a mammal which comprises parenterally administering to said ammal an effective musCle relaxation amount of the compound or claim 7.
12. The method of producing muscle relaxation in a mammal which comprises parenterally administering an effective muscle relaxant amount of the compound of claim 8 to said mammal.
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