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Last Updated: March 29, 2024

Claims for Patent: 4,285,957


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Summary for Patent: 4,285,957
Title: 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof
Abstract:Novel compounds of the following formula: ##STR1## wherein R.sub.1 is hydrogen or hydroxy; R.sub.2 is hydrogen; or R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ; n is an integer of from 1 to 5; R.sub.3 is --CH.sub.3, --CH.sub.2 OH, --COOH or --COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; and each of A and B is hydrogen or hydroxy; with the provisos that at least one of A or B is hydrogen and one of A or B is other than hydrogen when R.sub.3 is --CH.sub.3 ; and pharmaceutically acceptable salts thereof.
Inventor(s): Carr; Albert A. (Cincinnati, OH), Dolfini; Joseph E. (Cincinnati, OH), Wright; George J. (Richmond, VA)
Assignee: Richardson-Merrell Inc. (Wilton, CT)
Application Number:06/196,505
Patent Claims: 1. A compound of the formula ##STR13## wherein R.sub.1 represents hydrogen or hydroxy; R.sub.2 represents hydrogen; or R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ; n is an integer of from 1 to 5; R.sub.3 is --CH.sub.3, or --CH.sub.2 OH; each of A and B is hydrogen or hydroxy; with the provisos that at least one of A or B is hydrogen and one of A or B is other than hydrogen when R.sub.3 is --CH.sub.3 ; and pharmaceutically acceptable salts and individual optical isomers thereof.

2. A compound of claim 1 wherein R.sub.1 is hydrogen or R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2.

3. A compound of claim 1 which is .alpha.,.alpha.-diphenyl-1-(4-(4-hydroxy-tert-butyl)phenyl)-4-hydroxybutyl -4-piperidinemethanol or a pharmaceutically acceptable salt thereof.

4. A compound of claim 1 which is .alpha.,.alpha.-diphenyl-1-(4-(4-tert-butyl-2-hydroxy)phenyl)-4-hydroxybut yl-4-piperidinemethanol or a pharmaceutically acceptable salt thereof.

5. A pharmaceutical composition in unit dosage form comprising an effectie antiallergic amount of a compound of claim 1 and a significant amount of a pharmaceutically acceptable carrier.

6. A method of treating allergic reactions in a patient in need thereof which comprises administering to said patient an anti-allergically effective amount of a compound of claim 1.

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