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Claims for Patent: 4,219,559

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Claims for Patent: 4,219,559

Title: N-Heterocyclyl-4-piperidinamines
Abstract:Novel N-heterocyclyl-4-piperidinamines wherein said heterocyclic radical is an optionally substituted 1H-benzimidazol-2-yl or 3H-imidazo[4,5-b]pyridin-2-yl radical, said compounds being useful as antihistaminic agents.
Inventor(s): Janssens; Frans (Rijmenam, BE), Stokbroekx; Raymond (Beerse, BE), Torremans; Joseph (Beerse, BE), Luyckx; Marcel (Geel, BE)
Assignee: Janssen Pharmaceutica N.V. (Beerse, BE)
Application Number:06/002,276
Patent Claims: 1. A chemical compound selected from the group consisting of a N-heterocyclyl-4-piperidinamine having the formula ##STR38## and the pharmaceutically acceptable acid addition salts thereof, wherein R is a member selected from the group consisting of hydrogen and lower alkyl;

R.sup.1 is a member selected from the group consisting of hydrogen, lower alkyl, cycloalkyl, aryllower alkyl and lower alkanoyl;

R.sup.2 is a member from the group consisting of hydrogen, alkyl having from 1 to 10 carbon atoms, aryl, cycloalkyl and mono- and diaryl(lower alkyl);

R.sup.3 is a member independently selected from the group consisting of, halo, lower alkyl, lower alkyloxy and trifluoromethyl;

n is an integer of from 0 to 2 inclusive;

Q is a member selected from the group consisting of CH and N; and

L is a member selected from the group consisting of lower alkyl, which is optionally substituted with up to 3 substituents each independently selected from the group consisting of halo, cyano, hydroxy, isothiocyanato, lower alkyloxy, aryl, aryloxy, arylthio, arylsulfonyl, amino; lower alkenyl; aryllower alkenyl; cycloalkyl, being optionally substituted with a cyano and/or or an aryl group; 1-(aryllower alkyl)-1H-benzimidazol-2-yl; and a radical of the formula Z-C.sub.m H.sub.2m -, wherein

m is an integer of from 1 to 6 inclusive; and

Z is a member selected from the group consisting of 4,5-dihydro-5-oxo-1H-tetrazol-1-yl, being optionally substituted in its 4-position by an aryl radical or a lower alkyl radical; 2,3-dihydro-1,4-benzodioxin-2-yl; 2,3-dihydro-1,4-benzodioxin-6-yl; 2,3-dihydro-2-oxo-1H-benzimidazol-1-yl; 2,3-dihydro-3-oxo-4H-benzoxazin-4-yl; (10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)methyl; 4-morpholinyl; 1-piperidinyl; 1-pyrrolidinyl; a radical of the formula T-N(R.sup.4)-, wherein

R.sup.4 is a member selected from the group consisting of hydrogen, lower alkyl and aryllower alkyl; and

T is a member selected from the group consisting of lower alkyl, aryl, aryllower alkyl, 1H-benzimidazol-2-yl; and

a radical of the formula ##STR39## wherein s is the integer 0 or 1;

X is a member selected from the group consisting of O and --N(R.sup.5)-, said R.sup.5 being a member selected from the group consisting of hydrogen, lower alkyl, aryllower alkyl, lower alkanoyl and aroyl; and

W is a member selected from the group consisting of lower alkyl, aryl, aryllower alkyl, amino, arylamino, mono- and di(lower alkyl)amino, mono- and di(aryllower alkyl)amino, 1-piperidinyl, 1-pyrrolidinyl and 4-morpholinyl;

where aryl as used in the foregoing definitions, is a member selected from the group consisting of phenyl, substituted phenyl, naphthalenyl, thienyl, halothienyl, (lower alkyl)thienyl, pyridinyl, mono- and di(lower alkyloxy)pyridinyl, furanyl and 1-(lower alkyl)pyrrolyl; wherein said substituted phenyl is phenyl having from 1 to 3 substituents each independently selected from the group consisting of halo, hydroxy, nitro, cyano, trifluoromethyl, lower alkyl, lower alkylthio, lower alkylsulfonyl, lower alkylsulfonyllower alkyl, phenyllower alkylsulfonyl, phenylsulfonyllower alkyl, amino, mono- and di-(lower alkyl)amino, lower alkanoyl, a radical of the formula R.sup.6 --C.sub.p H.sub.2p --O--, wherein

p is an integer of from 1 to 6 inclusive; and

R.sup.6 is a member selected from the group consisting of hydrogen, amino, cyano, phenyl, aminocarbonyl, mono- and di(lower alkyl)aminocarbonyl, lower alkyloxycarbonyl, phenyllower alkyloxycarbonyl, 4-morpholinylcarbonyl, 1-piperidinylcarbonyl and 1-pyrrolidinylcarbonyl, and a radical of the formula R.sup.7 --O--, wherein

R.sup.7 is a member selected from the group consisting of alkanoyl, phenylcarbonyl, phenyllower alkylcarbonyl, lower alkyloxycarbonyl, phenyllower alkyloxycarbonyl, aminocarbonyl, phenylaminocarbonyl, mono- and di-(lower alkyl)aminocarbonyl wherein said phenyl in the definition of said R.sup.7 may be optionally substituted with up to 3 substituents each independently selected from the group consisting of halo, cyano, nitro, lower alkyl and lower alkyloxy; and

wherein said aroyl in the definition of said L represents arylcarbonyl wherein said aryl is as defined hereabove.

2. A chemical compound selected from the group consisting of 1-(4-fluorophenylmethyl)-N-{1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl}-1H -benzimidazol-2-amine and the pharmaceutically acceptable acid addition salts thereof.

3. A chemical compound selected from the group consisting of 4-[2-{4-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-ylamino]-1-piperidinyl }ethyl]phenol and the pharmaceutically acceptable acid addition salts thereof.

4. A chemical compound selected from the group consisting of {4-[2-{4-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-ylamino]-1-piperidiny l}ethyl]phenyl}benzeneacetate and the pharmaceutically acceptable acid addition salts thereof.

5. A chemical compound selected from the group consisting of {4-[2-{4-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-ylamino]-1-piperidiny l}ethyl]phenoxy}acetonitrile and the pharmaceutically acceptable acid addition salts thereof.

6. An antihistaminic pharmaceutical composition comprising an inert carrier material and as an active ingredient an effective antihistaminic amount of a chemical compound selected from the group consisting of a N-heterocyclyl-4-piperidinamine having the formula ##STR40## and the pharmaceutically acceptable acid addition salts thereof, wherein R is a member selected from the group consisting of hydrogen and lower alkyl;

R.sup.1 is a member selected from the group consisting of hydrogen, lower alkyl, cycloalkyl, aryllower alkyl and lower alkanoyl;

R.sup.2 is a member selected from the group consisting of hydrogen, alkyl having from 1 to 10 carbon atoms, aryl, cycloalkyl and mono- and diaryl(lower alkyl);

R.sup.3 is a member independently selected from the group consisting of halo, lower alkyl, lower alkyloxy, trifluoromethyl;

n is an integer of from 0 to 2 inclusive;

Q is a member selected from the group consisting of CH and N; and

L is a member selected from the group consisting of lower alkyl, which is optionally substituted with up to 3 substituents each independently selected from the group consisting of halo, cyano, hydroxy, isothiocyanato, lower alkyloxy, aryl, aryloxy, arylthio, arylsulfonyl, amino; lower alkenyl; aryllower alkenyl; cycloalkyl, being optionally substituted with a cyano and/or an aryl group; 1-(aryllower alkyl)-1H-benzimidazol-2-yl; and a radical of the formula Z-C.sub.m H.sub.2m --, wherein

m is an integer of from 1 to 6 inclusive; and

Z is a member selected from the group consisting of 4,5-dihydro-5-oxo-1H-tetrazol-1-yl, being optionally substituted in its 4-position by an aryl radical or a lower alkyl radical; 2,3-dihydro-1,4-benzodioxin-2-yl; 2,3-dihydro-1,4-benzodioxin-6-yl; 2,3-dihydro-2-oxo-1H-benzimidazol-1-yl; 2,3-dihydro-3-oxo-4H-benzoxazin-4-yl; (10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)methyl; 4-morpholinyl; 1-piperidinyl; 1-pyrrolidinyl; a radical of the formula T-N(R.sup.4)-, wherein

R.sup.4 is a member selected from the group consisting of hydrogen, lower alkyl and aryllower alkyl; and

T is a member selected from the group consisting of lower alkyl, aryl, aryllower alkyl, 1H-benzimidazol-2yl; and

a radical of the formula ##STR41## wherein s is the integer 0 or 1;

X is a member selected from the group consisting of O and -N(R.sup.5)-, said R.sup.5 being a member selected from the group consisting of hydrogen, lower alkyl, aryllower alkyl, lower alkanoyl and aroyl; and

W is a member selected from the group consisting of lower alkyl, aryl, aryllower alkyl, amino, arylamino, mono- and di(lower alkyl)amino, mono- and di(aryllower alkyl)amino, 1-piperidinyl, 1-pyrrolidinyl and 4-morpholinyl;

wherein aryl as used in the foregoing definitions, is a member selected from the group consisting of phenyl, substituted phenyl, naphthalenyl, thienyl, halothienyl, (lower alkyl)thienyl, pyridinyl, mono- and di(lower alkyloxy)pyridinyl, furanyl and 1-(lower alkyl)pyrrolyl; wherein said substituted phenyl is phenyl having from 1 to 3 substituents each independently selected from the group consisting of halo, hydroxy, nitro, cyano, trifluoromethyl, lower alkyl, lower alkylthio, lower alkylsulfonyl, lower alkylsulfonyllower alkyl, phenyllower alkylsulfonyl, phenylsulfonyllower alkyl, amino, mono- and di-(lower alkyl)amino, lower alkanoyl, a radical of the formula R.sup.6 --C.sub.p H.sub.2p --O--, wherein

p is an integer of from 1 to 6 inclusive; and

R.sup.6 is a member selected from the group consisting of hydrogen, amino, cyano, phenyl, aminocarbonyl, mono- and di(lower alkyl)aminocarbonyl, lower alkyloxycarbonyl, phenyllower alkyloxycarbonyl, 4-morpholinylcarbonyl, 1-piperidinylcarbonyl and 1-pyrrolidinylcarbonyl, lower alkenyl; and

a radical of the formula R.sup.7 -O-, wherein

R.sup.7 is a member selected from the group consisting of alkanoyl, phenylcarbonyl, phenyllower alkylcarbonyl, lower alkyloxycarbonyl, phenyllower alkyloxycarbonyl, aminocarbonyl, phenylaminocarbonyl, mono- and di-(lower alkyl)aminocarbonyl, wherein said phenyl in the definition of said R.sup.7 may be optionally substituted with up to 3 substituents each independently selected from the group consisting of halo, cyano, nitro, lower alkyl and lower alkyloxy; and

wherein said aroyl in the definition of said L represents arylcarbonyl wherein said aryl is as defined hereabove.

7. An antihistaminic pharmaceutical composition comprising an inert carrier material and as an active ingredient an effective antihistaminic amount of a chemical compound selected from the group consisting of 1-(4-fluorophenylmethyl)-N-{1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl}-1H -benzimidazol-2-amine and the pharmaceutically acceptable acid addition salts thereof.

8. An antihistaminic pharmaceutical composition comprising an inert carrier material and as an active ingredient an effective antihistaminic amount of a chemical compound selected from the group consisting of 4-[2-{4-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-ylamino]-1-piperidinyl }ethyl]phenol and the pharmaceutically acceptable acid addition salts thereof.

9. An antihistaminic pharmaceutical composition comprising an inert carrier material and as an active ingredient an effective antihistaminic amount of a chemical compound selected from the group consisting of {4-[2-{4-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-ylamino]-1-piperidiny l}ethyl]phenyl}benzeneacetate and the pharmaceutically acceptable acid addition salts thereof.

10. An antihistaminic pharmaceutical composition comprising an inert carrier material and as an active ingredient an effective antihistaminic amount of a chemical compound selected from the group consisting of {4-[2-{4-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-ylamino]-1-piperidiny l}ethyl]phenoxy}acetonitrile and the pharmaceutically acceptable acid addition salts thereof.

11. A method to prevent the release of histamine in warm-blooded animals, which comprises the systemic administration to said animals of an effective antihistaminic amount of a chemical compound selected from the group consisting of a N-heterocyclyl-4-piperidinamine having the formula ##STR42## and the pharmaceutically acceptable acid addition salts thereof, wherein R is a member selected from the group consisting of hydrogen and lower alkyl;

R.sup.1 is a member selected from the group consisting of hydrogen, lower alkyl, cycloalkyl, aryllower alkyl and lower alkanoyl;

R.sup.2 is a member selected from the group consisting of hydrogen, alkyl having from 1 to 10 carbon atoms, aryl, cycloalkyl and mono- and diaryl(lower alkyl);

R.sup.3 is a member independently selected from the group consisting of halo, lower alkyl, lower alkyloxy, trifluoromethyl;

n is an integer of from 0 to 2 inclusive;

Q is a member selected from the group consisting of CH and N; and

L is a member selected from the group consisting of lower alkyl, which is optionally substituted with up to 3 substituents each independently selected from the group consisting of halo, cyano, hydroxy, isothiocyanato, lower alkyloxy, aryl, aryloxy, arylthio, arylsulfonyl, amino; lower alkenyl; aryllower alkenyl; cycloalkyl, being optionally substituted with a cyano and/or an aryl group; 1-(aryllower alkyl)-1H-benzimidazol-2-yl; and a radical of the formula Z-C.sub.m H.sub.2m -, wherein

m is an integer of from 1 to 6 inclusive; and

Z is a member selected from the group consisting of 4,5-dihydro-5-oxo-1H-tetrazol-1-yl, being optionally substituted in its 4-position by an aryl radical or a lower alkyl radical; 2,3-dihydro-1,4-benzodioxin-2-yl; 2,3-dihydro-1,4-benzodioxin-6-yl; 2,3-dihydro-2-oxo-1H-benzimidazol-1yl; 2,3-dihydro-3-oxo-4H-benzoxazin-4-yl; (10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)methyl; 4-morpholinyl; 1-piperidinyl; 1-pyrrolidinyl; a radical of the formula T-N(R.sup.4)-, wherein

R.sup.4 is a member selected from the group consisting of hydrogen, lower alkyl and aryllower alkyl; and

T is a member selected from the group consisting of lower alkyl, aryl, aryllower alkyl, 1H-benzimidazol-2-yl; and

a radical of the formula ##STR43## wherein s is the integer 0 or 1;

X is a member selected from the group consisting of O and -N(R.sup.5)--, said R.sup.5 being a member selected from the group consisting of hydrogen, lower alkyl, aryllower alkyl, lower alkanoyl and aroyl; and

W is a member selected from the group consisting of lower alkyl, aryl, aryllower alkyl, amino, arylamino, mono- and di(lower alkyl)amino, mono- and di(aryllower alkyl)amino, 1-piperidinyl, 1-pyrrolidinyl and 4-morpholinyl;

wherein aryl as used in the foregoing definitions, is a member selected from the group consisting of phenyl, substituted phenyl, naphthalenyl, thienyl, halothienyl, (lower alkyl)thienyl, pyridinyl, mono- and di(lower alkyloxy)pyridinyl, furanyl and 1-(lower alkyl)pyrrolyl; wherein said substituted phenyl is phenyl having from 1 to 3 substituents each independently selected from the group consisting of halo, hydroxy, nitro, cyano, trifluoromethyl, lower alkyl, lower alkylthio, lower alkylsulfonyl, lower alkylsulfonyllower alkyl, phenyllower alkylsulfonyl, phenylsulfonyllower alkyl, amino, mono- and di-(lower alkyl)amino, lower alkanoyl, a radical of the formula R.sup.6 --C.sub.p H.sub.2p -O--, wherein

p is an integer of from 1 to 6 inclusive; and

R.sup.6 is a member selected from the group consisting of hydrogen, amino, cyano, phenyl, aminocarbonyl, mono- and di(lower alkyl)aminocarbonyl, lower alkyloxycarbonyl, phenyllower alkyloxycarbonyl, 4-morpholinylcarbonyl, 1-piperidinylcarbonyl and 1-pyrrolidinylcarbonyl, lower alkenyl; and

a radical of the formula R.sup.7 -O--, wherein

R.sup.7 is a member selected from the group consisting of alkanoyl, phenylcarbonyl, phenyllower alkylcarbonyl, lower alkyloxycarbonyl, phenyllower alkyloxycarbonyl, aminocarbonyl, phenylaminocarbonyl, mono- and di(lower alkyl)aminocarbonyl,

wherein said phenyl in the definition of said R.sup.7 may be optionally substituted with up to 3 substituents each independently selected from the group consisting of halo, cyano, nitro, lower alkyl and lower alkyloxy; and

wherein said aroyl in the definition of said L represents arylcarbonyl wherein said aryl is as defined hereabove.

12. A method to prevent the release of histamine is warm-blooded animals, which comprises the systemic administration to said animals of an effective antihistaminic amount of a chemical compound selected from the group consisting of 1-(4-fluorophenylmethyl)-N-{1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl}-1H -benzimidazol-2-amine and the pharmaceutically acceptable acid addition salts thereof.

13. A method to prevent the release of histamine in warm-blooded animals, which comprises the systemic administration to said animals of an effective antihistaminic amount of a chemical compound selected from the group consisting of 4-[2-{4-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-ylamino]-1-piperidinyl }-ethyl]phenol and the pharmaceutically acceptable acid addition salts thereof.

14. A method to prevent the release of histamine in warm-blooded animals, which comprises the systemic administration to said animals of an effective antihistaminic amount of a chemical compound selected from the group consisting of {4-[2-{4-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-ylamino]-1-piperidiny l}ethyl]phenyl}benzeneacetate and the pharmaceutically acceptable acid addition salts thereof.

15. A method to prevent the release of histamine in warm-blooded animals, which comprises the systemic administration to said animals of an effective antihistaminic amount of a chemical compound selected from the group consisting of {4-[2-{4-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-ylamino]-1-piperidiny l}ethyl]phenoxy}acetonitrile and the pharmaceutically acceptable acid addition salts thereof.

16. A chemical compound having the formula ##STR44## wherein: L.sup.1 is a member selected from the group consisting of hydrogen, lower alkyloxycarbonyl and phenylmethoxycarbonyl;

R is a member selected from the group consisting of hydrogen and lower alkyl;

R.sup.1 is a member selected from the group consisting of hydrogen lower alkyl, cycloalkyl, aryllower alkyl and lower alkanoyl;

R.sup.2 is a member selected from the group consisting of hydrogen, alkyl having from 1 to 10 carbon atoms, aryl, cycloalkyl and mono- and diaryl(lower alkyl);

R.sup.3 is a member independently selected from the group consisting of, halo, lower alkyl, lower alkyloxy, trifluoromethyl;

n is an integer of from 0 to 2 inclusive;

Q is a member selected from the group consisting of CH and N; and wherein aryl as used in the foregoing definitions, is a member selected from the group consisting of phenyl, substituted phenyl, naphthalenyl, thienyl, halothienyl, (lower alkyl)thienyl, pyridinyl, mono- and di(lower alkyloxy)pyridinyl, furanyl and 1-(lower alkyl)pyrrolyl; wherein said substitued phenyl is phenyl having from 1 to 3 substituents each independently selected from the group consisting of halo, hydroxy, nitro, cyano, trifluoromethyl, lower alkyl, lower alkylthio, lower alkylsulfonyl, lower alkylsulfonyllower alkyl, phenyllower alkylsulfonyl, phenylsulfonyllower alkyl, amino, mono- and di-(lower alkyl)amino, lower alkanoyl, a radical of the formula R.sup.6 --C.sub.p H.sub.2p -O--, wherein

p is an integer of from 1 to 6 inclusive; and

R.sup.6 is a member selected from the group consisting of hydrogen, amino, cyano, phenyl, aminocarbonyl, mono- and di(lower alkyl)aminocarbonyl, lower alkyloxycarbonyl, phenyllower alkyloxycarbonyl, 4-morpholinylcarbonyl, 1-piperidinylcarbonyl and 1-pyrrolidinylcarbonyl, lower alkenyl; and

a radical of the formula R.sup.7 -O-, wherein

R.sup.7 is a member selected from the group consisting of alkanoyl, phenylcarbonyl, phenyllower alkylcarbonyl, lower alkyloxycarbonyl, phenyllower alkyloxycarbonyl, aminocarbonyl, phenylaminocarbonyl, mono- and di(lower alkyl)aminocarbonyl and phenylcarbonyl, wherein said phenyl in the definition of said R.sup.7 may be optionally substituted with up to 3 substituents each independently selected from the group consisting of halo, cyano, nitro, lower alkyl and lower alkyloxy.

17. A chemical compound selected from the group consisting of a N-heterocyclyl-4-piperidinamine having the formula ##STR45## and the pharmaceutically acceptable acid addition salts thereof, wherein R is a member selected from the group consisting of hydrogen and lower alkyl;

R.sup.1 is a member selected from the group consisting of hydrogen, lower alkyl, cycloalkyl, aryllower alkyl and lower alkanoyl;

R.sup.2 is a member selected from the group consisting of hydrogen, alkyl having from 1 to 10 carbon atoms, aryl, cycloalkyl and mono- and diaryl(lower alkyl);

R.sup.3 is a member independently selected from the group consisting of halo, lower alkyl, lower alkyloxy and trifluoromethyl;

n is an integer of from 0 to 2 inclusive; Q is a member selected from the group consisting of CH and N; and L is a member selected from the group consisting of lower alkyl, which is optionally substituted with up to 3 substituents each independently selected from the group consisting of halo, cyano, hydroxy, isothiocyanato, lower alkyloxy, aryl, aryloxy, arylthio, arylsulfonyl, amino; lower alkenyl; and aryllower alkenyl; wherein aryl as used in the foregoing definitions, is a member selected from the group consisting of phenyl, substituted phenyl, naphthalenyl, thienyl, halothienyl, (lower alkyl)thienyl, pyridinyl, mono- and di(lower alkyloxy)pyridinyl, furanyl and 1-(lower alkyl)pyrrolyl; wherein said substituted phenyl is phenyl having from 1 to 3 substituents each independently selected from the group consisting of halo, hydroxy, nitro, cyano, trifluoromethyl, lower alkyl, lower alkylthio, lower alkylsulfonyl, lower alkylsulfonyllower alkyl, phenyllower alkylsulfonyl, phenylsulfonyllower alkyl, amino, mono- and di-(lower alkyl)amino, lower alkanoyl, a radical of the formula R.sup.6 --C.sub.p H.sub.2p --O--, wherein

p is an integer of from 1 to 6 inclusive; and R.sup.6 is a member selected from the group consisting of hydrogen, amino, cyano, phenyl, aminocarbonyl, mono- and di(lower alkyl)aminocarbonyl, lower alkyloxycarbonyl, phenyllower alkyloxycarbonyl, 4-morpholinylcarbonyl, 1-piperidinylcarbonyl and 1-pyrrolidinylcarbonyl, and

a radical of the formula R.sup.7 --O--, wherein

R.sup.7 is a member selected from the group consisting of alkanoyl, phenylcarbonyl, phenyllower alkylcarbonyl, lower alkyloxycarbonyl, phenyllower alkyloxycarbonyl, aminocarbonyl, phenylaminocarbonyl, mono- and di-(lower alkyl)aminocarbonyl, wherein said phenyl in the definition of said R.sup.7 may be optionally substituted with up to 3 substituents each independently selected from the group consisting of halo, cyano, nitro, lower alkyl and lower alkyloxy.

18. An antihistaminic pharmaceutical composition comprising an inert carrier material and as an active ingredient an effective antihistaminic amount of a chemical compound selected from the group consisting of a N-heterocyclyl-4-piperidinamine having the formula ##STR46## and the pharmaceutically acceptable acid addition salts thereof, wherein R is a member selected from the group consisting of hydrogen and lower alkyl;

R.sup.1 is a member selected from the group consisting of hydrogen, lower alkyl, cycloalkyl, aryllower alkyl and lower alkanoyl;

R.sup.2 is a member selected from the group consisting of hydrogen, alkyl having from 1 to 10 carbon atoms, aryl, cycloalkyl and mono- and diaryl(lower alkyl);

R.sup.3 is a member independently selected from the group consisting of halo, lower alkyl, lower alkyloxy, trifluoromethyl;

n is an integer of from 0 to 2 inclusive;

Q is a member selected from the group consisting of CH and N; and L is a member selected from the group consisting of lower alkyl, which is optionally substituted with up to 3 substituents each independently selected from the group consisting of halo, cyano, hydroxy, isothiocyanato, lower alkyloxy, aryl, aryloxy, arylthio, arylsulfonyl, amino; lower alkenyl and aryllower alkenyl; wherein aryl as used in the foregoing definitions, is a member selected from the group consisting of phenyl, substituted phenyl, naphthalenyl, thienyl, halothienyl, (lower alkyl)thienyl, pyridinyl, mono- and di(lower alkyloxy)pyridinyl, furanyl and 1-(lower alkyl)pyrrolyl; wherein said substituted phenyl is phenyl having from 1 to 3 substituents each independently selected from the group consisting of halo, hydroxy, nitro, cyano, trifluoromethyl, lower alkyl, lower alkylthio, lower alkylsulfonyl, lower alkylsulfonyllower alkyl, phenyllower alkylsulfonyl, phenylsulfonyllower alkyl, amino, mono- and di-(lower alkyl)amino, lower alkanoyl, a radical of the formula R.sup.6 --C.sub.p H.sub.2p --O--, wherein

p is an integer of from 1 to 6 inclusive; and R.sup.6 is a member selected from the group consisting of hydrogen, amino, cyano, phenyl, aminocarbonyl, mono- and di(lower alkyl)aminocarbonyl, lower alkyloxycarbonyl, phenyllower alkyloxycarbonyl, 4-morpholinylcarbonyl, 1-piperidinylcarbonyl and 1-pyrrolidinylcarbonyl, lower alkenyl; and

a radical of the formula R.sup.7 --O--, wherein

R.sup.7 is a member selected from the group consisting of alkanoyl, phenylcarbonyl, phenyllower alkylcarbonyl, lower alkyloxycarbonyl, phenyllower alkyloxycarbonyl, aminocarbonyl, phenylaminocarbonyl, mono- and di-(lower alkyl)aminocarbonyl,

wherein said phenyl in the definition of said R.sup.7 may be optionally substituted with up to 3 substituents each independently selected from the group consisting of halo, cyano, nitro, lower alkyl and lower alkyloxy.

19. A method to prevent the release of histamine in warm-blooded animals, which comprises the systemic administration to said animals of an effective antihistaminic amount of a chemical compound selected from the group consisting of a N-heterocyclyl-4-piperidinamine having the formula ##STR47## and the pharmaceutically acceptable acid addition salts thereof, wherein R is a member selected from the group consisting of hydrogen and lower alkyl;

R.sup.1 is a member selected from the group consisting of hydrogen, lower alkyl, cycloalkyl, aryllower alkyl and lower alkanoyl;

R.sup.2 is a member selected from the group consisting of hydrogen, alkyl having from 1 to 10 carbon atoms, aryl, cycloalkyl and mono- and diaryl(lower alkyl);

R.sup.3 is a member independently selected from the group consisting of halo, lower alkyl, lower alkyloxy, trifluoromethyl;

n is an integer of from 0 to 2 inclusive;

Q is a member selected from the group consisting of CH and N; and

L is a member selected from the group consisting of lower alkyl, which is optionally substituted with up to 3 substituents each independently selected from the group consisting of halo, cyano, hydroxy, isothiocyanato, lower alkyloxy, aryl, aryloxy, arylthio, arylsulfonyl, amino; lower alkenyl; aryllower alkenyl; wherein aryl as used in the foregoing definitions, is a member selected from the group consisting of phenyl, substituted phenyl, naphthalenyl, thienyl, halothienyl, (lower alkyl)thienyl, pyridinyl, mono- and di(lower alkyloxy)pyridinyl, furanyl and 1-(lower alkyl)pyrrolyl; wherein said substituted phenyl is phenyl having from 1 to 3 substituents each independently selected from the group consisting of halo, hydroxy, nitro, cyano, trifluoromethyl, lower alkyl, lower alkylthio, lower alkylsulfonyl, lower alkylsulfonyllower alkyl, phenyllower alkylsulfonyl, phenylsulfonyllower alkyl, amino, mono- and di-(lower alkyl)amino, lower alkanoyl, a radical of the formula R.sup.6 --C.sub.p H2p--O--, wherein

p is an integer of from 1 to 6 inclusive; and R.sup.6 is a member selected from the group consisting of hydrogen, amino, cyano, phenyl, aminocarbonyl, mono- and di(lower alkyl)aminocarbonyl, lower alkyloxycarbonyl, phenyllower alkyloxycarbonyl, 4-morpholinylcarbonyl, 1-piperidinylcarbonyl and 1-pyrrolidinylcarbonyl, lower alkenyl; and

a radical of the formula R.sup.7 --O--, wherein

R.sup.7 is a member selected from the group consisting of alkanoyl, phenylcarbonyl, phenyllower alkylcarbonyl, lower alkyloxycarbonyl, phenyllower alkyloxycarbonyl, aminocarbonyl, phenylaminocarbonyl, mono- and di-(lower alkyl)aminocarbonyl, wherein said phenyl in the definition of said R.sup.7 may be optionally substituted with up to 3 substituents each independently selected from the group consisting of halo, cyano, nitro, lower alkyl and lower alkyloxy.
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