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Claims for Patent: 4,211,771

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Claims for Patent: 4,211,771

Title: Treatment of human viral diseases with 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide
Abstract:The compound 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide is used to treat diseases in humans which are caused by viral infections.
Inventor(s): Witkowski; Joseph T. (Morris Township, Morris County, NJ), Robins; Roland K. (Provo, UT)
Assignee:
Application Number:05/877,313
Patent Claims: 1. A process of treating viral diseases in humans which comprises administering to the human patients an antiviral agent which has as its active component the compound 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide.

2. A process of treating viral diseases in humans which are caused by poxviruses, herpes viruses, othomyxoviruses or paramyxoviruses which comprises administering to the human patients an antiviral agent which has as its active component the compound 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide.

3. The process of claim 2 wherein the viral disease is caused by a member of the poxviruses.

4. The process of claim 2 wherein the viral disease is caused by a member of the herpesviruses.

5. The process of claim 2 wherein the viral disease is caused by a member of the othomyxoviruses.

6. The process of claim 2 wherein the viral disease is caused by a member of theparamyxoviruses.

7. A process of treating viral diseases in humans comprising administering to the human patients an effective amount of a composition containing from about 0.01% to 50% by weight, based on the total weight of the composition, of the compound 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide.

8. A process of treating viral diseases in humans which are caused by poxviruses, herpes viruses, othomyxoviruses or paramyxoviruses comprising administering to the human patient an effective amount of a composition contianing from about 0.01% to 50% by weight, based on the total weight of the composition of the compound 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide.

9. The process of claim 8 wherein the composition is administered orally.

10. The process of claim 8 wherein the composition is administered topically.

11. The process of claim 8 wherein the composition is administered by injection.

12. The process of claim 8 wherein the composition is administered via the respitory tract.

13. The process of claim 8 wherein the composition is administered ophthalmically.

14. A process for treating viral hepatitis in humans which comprieses administering to a patient an oral preparation containing as its active ingredient the compound 1-B-D-ribofuranosyl 1,2,4-triazole-3-carboxamide in a total daily dose of approximately 100 to 1000 milligrams of the compound.

15. The process of claim 5 for treating influenza in humans which comprises administering to a patient a composition containing as its active ingredient the compound 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide in a total daily dose of approximately 100 to 1000 milligrams of the compound.

16. The process of claim 15 wherein the composition is administered orally.

17. The process of claim 4 of treating herpes labialis, herpes progenitalis, herpes zoster, and herpes gingivostomatitis in humans which comprises administering to a patient a composition containing as its active ingredient the compound 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide.

18. The process of claim 17 wherein the composition is administered orally in a total daily dose of approximately 100 to 1000 milligrams of the compound.

19. The process of claim 17 wherein the composition is a topical composition containing from about 0.5% to 5% of the compound.

20. A process for treating measles in humans which comprises administering to a patient a composition containing as its active ingredient the compound 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide, in a total daily dose of approximately 100 to 1000 milligrams of the compound.
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