.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 3,863,004

« Back to Dashboard

Claims for Patent: 3,863,004

Title: DENATURED MACROPROTEIN WITH DIVALENT TIN FOR TAGGING WITH TECHNETIUM-99M AND METHOD OF PREPARATION
Abstract:An improved composition suitable for tagging with technetium-99m and use in lung scanning procedures consists essentially of an injectable suspension in buffer solution of particles of a denatured macroprotein having divalent tin bound thereto. The macroprotein has a molecular weight of at least about 20,000. A method for preparing the injectable suspension by treating macroaggregates or microspheres of a denatured macroprotein with a solution containing divalent tin ions is also provided.
Inventor(s): Wolfangel; Robert G. (St. Louis, MO)
Assignee: Mallinckroft Chemical Works (St. Louis, MO)
Application Number:05/236,159
Patent Claims: 1. A composition suitable for rapid tagging with technetium-99m and use in lung scanning procedures consisting essentially of an injectable suspension in a buffer solution of particles of denatured macroprotein having divalent tin bound thereto, said macroprotein having a molecular

2. A composition as set forth in claim 1 wherein the pH of said buffer solution is approximately the isoelectric pH of said denatured

3. A composition as set forth in claim 1 wherein said macroprotein

4. A composition as set forth in claim 1 wherein the size of the particles

5. A composition as set forth in claim 4 wherein the mean size of said

6. A composition as set forth in claim 1 including macroprotein particles

7. A composition as set forth in claim 1 wherein the buffer solution contains between about 8 % and about 16 % by weight of an antiagglomerating agent selected from the group consisting of propylene

8. A process for preparing a buffered injectable suspension of particles of denatured macroprotein suitable for rapid tagging with technetium-99m and use in lung scanning procedures comprising the steps of:

contacting particles of a denatured macroprotein with a solution containing a water-soluble salt of divalent tin causing divalent tin to be bound to said macroprotein;

washing the macroprotein having divalent tin bound thereto with a buffer solution; and

thereafter suspending in a buffer solution the macroprotein having divalent

9. A process as set forth in claim 8 wherein said macroprotein is human

10. A process as set forth in claim 8 wherein said solution containing

11. A process as set forth in claim 10 wherein said solution contains

12. A process as set forth in claim 8 wherein said macroprotein is in the

13. A process as set forth in claim 8 wherein said macroprotein is in the

14. A process as set forth in claim 8 wherein said macroprotein is prepared by precipitating denatured macroprotein in an acid medium at a pH approximately the isoelectric pH of said protein.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc