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Serving leading biopharmaceutical companies globally:

Queensland Health
Julphar
Citi
Harvard Business School
Dow
Fuji
Express Scripts
US Department of Justice
Johnson and Johnson
Merck

Generated: February 20, 2018

DrugPatentWatch Database Preview

Claims for Patent: 3,863,004

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Summary for Patent: 3,863,004
Title: DENATURED MACROPROTEIN WITH DIVALENT TIN FOR TAGGING WITH TECHNETIUM-99M AND METHOD OF PREPARATION
Abstract:An improved composition suitable for tagging with technetium-99m and use in lung scanning procedures consists essentially of an injectable suspension in buffer solution of particles of a denatured macroprotein having divalent tin bound thereto. The macroprotein has a molecular weight of at least about 20,000. A method for preparing the injectable suspension by treating macroaggregates or microspheres of a denatured macroprotein with a solution containing divalent tin ions is also provided.
Inventor(s): Wolfangel; Robert G. (St. Louis, MO)
Assignee: Mallinckroft Chemical Works (St. Louis, MO)
Application Number:05/236,159
Patent Claims: 1. A composition suitable for rapid tagging with technetium-99m and use in lung scanning procedures consisting essentially of an injectable suspension in a buffer solution of particles of denatured macroprotein having divalent tin bound thereto, said macroprotein having a molecular

2. A composition as set forth in claim 1 wherein the pH of said buffer solution is approximately the isoelectric pH of said denatured

3. A composition as set forth in claim 1 wherein said macroprotein

4. A composition as set forth in claim 1 wherein the size of the particles

5. A composition as set forth in claim 4 wherein the mean size of said

6. A composition as set forth in claim 1 including macroprotein particles

7. A composition as set forth in claim 1 wherein the buffer solution contains between about 8 % and about 16 % by weight of an antiagglomerating agent selected from the group consisting of propylene

8. A process for preparing a buffered injectable suspension of particles of denatured macroprotein suitable for rapid tagging with technetium-99m and use in lung scanning procedures comprising the steps of:

contacting particles of a denatured macroprotein with a solution containing a water-soluble salt of divalent tin causing divalent tin to be bound to said macroprotein;

washing the macroprotein having divalent tin bound thereto with a buffer solution; and

thereafter suspending in a buffer solution the macroprotein having divalent

9. A process as set forth in claim 8 wherein said macroprotein is human

10. A process as set forth in claim 8 wherein said solution containing

11. A process as set forth in claim 10 wherein said solution contains

12. A process as set forth in claim 8 wherein said macroprotein is in the

13. A process as set forth in claim 8 wherein said macroprotein is in the

14. A process as set forth in claim 8 wherein said macroprotein is prepared by precipitating denatured macroprotein in an acid medium at a pH approximately the isoelectric pH of said protein.

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Serving hundreds of leading biopharmaceutical companies globally:

Fish and Richardson
UBS
Colorcon
McKesson
Federal Trade Commission
Moodys
Boehringer Ingelheim
US Department of Justice
Daiichi Sankyo

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