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Generated: July 28, 2017

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Abstract:The preparation of 2-chloro-11-(1-piperazinyl)dibenz-[b,f][1,4]oxazepine by heating ethyl 4-{[o-(p-chlorophenoxy)-phenyl]carbamoyl}-1-piperazinecarboxylate with phosphorus pentoxide and phosphorus oxychloride, is described. The base compound and non-toxic acid addition salts are useful for their desirable effect on the central nervous system of warm-blooded animals.
Inventor(s): Howell; Charles Frederick (Upper Saddle River, NJ), Hardy, Jr.; Robert Allis (Ridgewood, NJ), Quinones; Nicanor Quinones (New York, NY)
Assignee: American Cyanamid Company (Stamford, CT)
Application Number:05/026,115
Patent Claims: 1. A compound of the formula: ##SPC3##

2. The compound according to claim 1 in which the salt is the

6. The compound according to claim 1 in which the salt is the succinate.

7. The compound according to claim 1 in which the salt is the diheptanoate.

8. The compound according to claim 1; 2-chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine.
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