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Last Updated: December 16, 2025

Claims for Patent: 11,026,899

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Summary for Patent: 11,026,899

Title:	Treatment or prevention of cardiovascular events via the administration of a colchicine derivative
Abstract:	A method for the treatment or prevention of a cardiovascular event in a subject with atherosclerotic vascular disease comprising the step of:
Inventor(s):	Mark Nidorf
Assignee:	Murray and Poole Enterprises Ltd
Application Number:	US17/103,562
Patent Claims:	1. A method for treating and/or reducing the risk of a cardiovascular event in a subject in need thereof, which comprises: administering to the subject a therapeutically effective amount of a composition comprising about 0.5 total mg of (i) colchicine, (ii) a salt of (i), or any combination of (i) and (ii), wherein the composition is administered orally and once per day. 2. The method of claim 1, wherein the composition is administered in the form of a tablet or capsule. 3. The method of claim 1, wherein the composition is administered in the form of a liquid dose, gel, or powder. 4. The method of claim 1, wherein the subject has atherosclerotic vascular disease. 5. The method of claim 4, wherein the atherosclerotic vascular disease is coronary disease. 6. The method of claim 1, wherein the composition reduces the risk of the subject experiencing a cardiovascular event by a greater percentage than a composition that does not include colchicine or a salt thereof, and wherein the risk of cardiovascular event is reduced by at least about 10%, at least about 20%, at least about 30%, at least about 40%, or at least about 50%. 7. The method of claim 6, wherein the risk of cardiovascular event is reduced by at least about 30%. 8. The method of claim 1, wherein the subject has a previous diagnosis of diabetes, past myocardial infarction, unstable angina, coronary bypass surgery, and/or coronary angioplasty. 9. The method of claim 1, wherein the subject is from about 35 to about 85 years of age. 10. The method of claim 1, wherein the cardiovascular event is acute coronary syndrome. 11. The method of claim 10, wherein the acute coronary syndrome is unstable angina. 12. The method of claim 10, wherein the acute coronary syndrome is ischemic chest pain, acute myocardial infarction, and/or unstable angina. 13. The method of claim 10, wherein the acute coronary syndrome is acute myocardial infarction. 14. The method of claim 1, wherein the cardiovascular event is cardiac arrest. 15. The method of claim 1, wherein the cardiovascular event is stroke. 16. The method of claim 10, wherein the acute coronary syndrome is due to stent disease or acute stent thrombosis. 17. The method of claim 13, wherein the acute myocardial infarction is non-stent related acute myocardial infarction. 18. The method of claim 1, wherein the subject is administered the composition daily for at least 24 months. 19. The method of claim 1, wherein the subject is administered the composition daily for at least 36 months. 20. The method of claim 1, wherein the subject is administered the composition daily for at least 44 months.

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