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Last Updated: June 16, 2024

Claims for Patent: 10,912,772

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Summary for Patent: 10,912,772

Title:	Opioid formulations
Abstract:	A depot precursor formulation comprising:
Inventor(s):	Tiberg Fredrik, Harwigsson Ian, Johnsson Markus
Assignee:	Camurus AB
Application Number:	US16882186
Patent Claims:	1. A method of administering an opioid maintenance treatment to a patient , the method comprising administering a composition to the patient from a pre-filled syringe containing the composition , wherein the composition is administered subcutaneously to the patient once-weekly and comprisesabout 5% by weight of buprenorphine;about 10% by weight of ethanol;about 42% by weight of a phosphatidylcholine; andabout 42% by weight of glycerol dioleate.2. The method of claim 1 , wherein the patient suffers from an opioid dependency.3. The method of claim 2 , wherein the patient suffers from opioid withdrawal.4. The method of claim 1 , wherein administering the opioid maintenance treatment treats pain in the patient.5. The method of claim 1 , wherein the composition comprises 3 to 40 mg of buprenorphine.6. The method of claim 1 , wherein the patient is receiving or has previously received an oral dosage form comprising buprenorphine.7. The method of claim 6 , wherein the oral dosage form is sublingual.8. The method of claim 1 , wherein the composition claim 1 , after contact with an aqueous fluid claim 1 , forms a liquid crystalline phase structure.9. The method of claim 8 , wherein the liquid crystalline phase structure is a non-lamellar crystalline phase structure.10. The method of claim 1 , wherein claim 1 , at steady state plasma concentrations claim 1 , the Cmin and Cmax of buprenorphine in the patient is between about 0.4 ng/mL and 10 ng/mL.11. The method of claim 1 , wherein the Cmin and Cmax of buprenorphine in the patient is between about 0.4 ng/mL and 10 ng/mL for at least a week after administration.12. The method of claim 1 , wherein the blood plasma concentration of buprenorphine in the patient is at least 0.2 ng/mL for at least a week.13. A method of administering an opioid maintenance treatment to a patient claim 1 , the method comprising administering a composition to the patient from a pre-filled syringe containing the composition claim 1 , wherein the composition is administered subcutaneously to the patient once-weekly and comprisesabout 5.29% by weight of buprenorphine;about 10% by weight of ethanol;about 42.36% by weight of a phosphatidylcholine; andabout 42.36% by weight of glycerol dioleate.14. The method of claim 13 , wherein the patient suffers from an opioid dependency.15. The method of claim 14 , wherein the patient suffers from opioid withdrawal.16. The method of claim 13 , wherein the composition comprises 3 to 40 mg of buprenorphine.

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