Claims for Patent: 10,758,550

Summary for Patent: 10,758,550

Title:	Treatment of allergic rhinitis using a combination of mometasone and olopatadine
Abstract:	The present invention relates to a method of treating allergic rhinitis in a subject (e.g., a pediatric human subject) in need thereof comprising nasally administering to the subject an effective amount of a fixed-dose pharmaceutical composition comprising mometasone or its salt and olopatadine or its salt.
Inventor(s):	Khairatkar-Joshi; Neelima (Thane, IN), Kulkarni; Abhay (Navi Mumbai, IN), Wale; Pradeep D. (Maharashtra, IN), Bhosale; Vikram M. (Mumbai, IN), Agarwal; Piyush (Mumbai, IN), Keohane; Patrick (London, GB), Tantry; Sudeesh K. (Jamison, PA), Oh; Chad (San Francisco, CA)
Assignee:	GLENMARK SPECIALTY S.A. (La Chaux-de-Fonds, CH)
Application Number:	15/903,597
Patent Claims:	1. A method of providing a faster onset of action for relief of allergic rhinitis in a pediatric human subject in need thereof, the method comprising nasally administering to a subject twice daily, one spray per nostril of a fixed-dose pharmaceutical composition comprising mometasone furoate and olopatadine hydrochloride, wherein (i) each spray comprises about 25 mcg of mometasone furoate and about 665 mcg olopatadine hydrochloride, and (ii) the administration provides relief from one or more symptoms of allergic rhinitis faster than nasal administration of 25 mcg mometasone furoate or 665 mcg olopatadine hydrochloride per nostril alone. 2. The method of claim 1, wherein the one or more symptoms are selected from nasal symptoms. 3. The method of claim 2, wherein the nasal symptoms are selected from nasal congestion, rhinorrhea, itching and sneezing. 4. The method of claim 1, wherein the human subject is 2 to under 12 years of age. 5. The method of claim 1, wherein the human subject is 2 to under 6 years of age. 6. The method of claim 1, wherein the human subject is 6 to under 12 years of age. 7. The method of claim 1, wherein the allergic rhinitis is selected from seasonal allergic rhinitis, perennial allergic rhinitis, and persistent allergic rhinitis. 8. The method of claim 7, wherein the allergic rhinitis is seasonal allergic rhinitis. 9. The method of claim 7, wherein the allergic rhinitis is perennial allergic rhinitis. 10. The method of claim 1, wherein the pediatric human subject is 2 years of age or older. 11. A method of treating one or more symptoms associated with allergic rhinitis in a pediatric human subject in need thereof comprising nasally administering twice daily, one spray per nostril of a fixed-dose pharmaceutical composition comprising mometasone furoate and olopatadine hydrochloride, wherein (i) each spray comprises about 25 mcg of mometasone furoate and about 665 mcg olopatadine hydrochloride and (ii) the administration of the pharmaceutical composition provides relief from one or more symptoms of allergic rhinitis within 15 minutes of administration. 12. A method of treating one or more symptoms associated with allergic rhinitis in a pediatric human subject in need thereof comprising nasally administering twice daily, one spray per nostril of a fixed-dose pharmaceutical composition comprising mometasone furoate and olopatadine hydrochloride, wherein (i) each spray comprises about 25 mcg of mometasone furoate and about 665 mcg olopatadine hydrochloride and (ii) the administration of the pharmaceutical composition provides relief from one or more symptoms of allergic rhinitis within 10 minutes of administration. 13. The method of claim 10, wherein the one or more symptoms are selected from nasal symptoms. 14. The method of claim 13, wherein the nasal symptoms are selected from nasal congestion, rhinorrhea, itching and sneezing. 15. The method of claim 10, wherein the human subject is at 2 to under 12 years of age. 16. The method of claim 10, wherein the human subject is 6 to under 12 years of age. 17. The method of claim 10, wherein the human subject is 2 to under 6 years of age. 18. The method of claim 10, wherein the allergic rhinitis is selected from seasonal allergic rhinitis, perennial allergic rhinitis, and persistent allergic rhinitis. 19. The method of claim 18, wherein the allergic rhinitis is seasonal allergic rhinitis. 20. The method of claim 18, wherein the allergic rhinitis is perennial allergic rhinitis. 21. The method of claim 10, wherein the allergic rhinitis is seasonal allergic rhinitis. 22. The method of claim 10, wherein the allergic rhinitis is perennial allergic rhinitis. 23. A method of treating one or more symptoms associated with allergic rhinitis in a pediatric human subject in need thereof comprising twice daily nasal administration of a single dose of a pharmaceutical composition comprising mometasone furoate and olopatadine hydrochloride, wherein (i) a single dose of the composition provides about 1330 mcg olopatadine hydrochloride and about 50 mcg mometasone furoate and (ii) the administration of the pharmaceutical composition provides relief from one or more symptoms of allergic rhinitis within 15 minutes of administration. 24. A method of treating one or more symptoms associated with allergic rhinitis in a pediatric human subject in need thereof comprising twice daily nasal administration of a single dose of a pharmaceutical composition comprising mometasone furoate and olopatadine hydrochloride, wherein (i) a single dose of the composition provides about 1330 mcg olopatadine hydrochloride and about 50 mcg mometasone furoate and (ii) the administration of the pharmaceutical composition provides relief from one or more symptoms of allergic rhinitis within 10 minutes of administration. 25. A method of providing a faster onset of action for relief of allergic rhinitis in a pediatric human subject in need thereof, the method comprising twice daily nasal administration of a single dose of a pharmaceutical composition comprising mometasone furoate and olopatadine hydrochloride, wherein (i) a single dose of the composition provides about 1330 mcg olopatadine hydrochloride and about 50 mcg mometasone furoate, and (ii) the administration provides relief from one or more symptoms of allergic rhinitis faster than nasal administration of 50 mcg mometasone furoate or 1330 mcg olopatadine hydrochloride alone. 26. The method of claim 25, wherein the pediatric human subject is 2 years of age or older. 27. The method of claim 25, wherein the human subject is 2 to under 12 years of age. 28. The method of claim 25, wherein the human subject is 2 to under 6 years of age. 29. The method of claim 25, wherein the human subject is 6 to under 12 years of age. 30. The method of claim 26, wherein the one or more symptoms are selected from nasal symptoms. 31. The method of claim 26, wherein the allergic rhinitis is seasonal allergic rhinitis. 32. The method of claim 26, wherein the allergic rhinitis is perennial allergic rhinitis.