Claims for Patent: 10,610,510

Summary for Patent: 10,610,510

Title:	Treatment of circadian rhythm disorders
Abstract:	Embodiments of the invention relate to the use of a melatonin agonist in the treatment of free running circadian rhythms in patients, including light perception impaired patients, e.g., blind patients, and to methods of measuring circadian rhythm.
Inventor(s):	Marlene Michelle Dressman, John Joseph Feeney, Louis William Licamele, Mihael H. Polymeropoulos
Assignee:	Vanda Pharmaceuticals Inc
Application Number:	US16/180,316
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 10,610,510
Patent Claims:	1. In a method of treating a patient for a circadian rhythm disorder in whom treatment with tasimelteon was ineffective, the improvement comprising: administering to the patient a dose of tasimelteon that is greater than 20 mg once daily before bedtime; or determining whether the patient is a smoker; instructing the patient to cease or reduce smoking; and administering to the patient 20 mg of tasimelteon once daily before bedtime. 2. The method of claim 1 wherein the patient is light perception impaired (LPI). 3. The method of claim 2 wherein the patient is totally blind. 4. The method of claim 1 wherein the tasimelteon is administered at 0.5 to 1.5 hours before bedtime. 5. The method of claim 4 wherein the tasimelteon is administered at about 1 hour before bedtime. 6. A method of treating a patient for a circadian rhythm disorder, the method comprising: determining whether the patient is a smoker; and in the case that the patient is determined to be a smoker: administering to the patient a dose of tasimelteon that is greater than 20 mg once daily before bedtime; or instructing the patient to cease or reduce smoking; and administering to the patient 20 mg of tasimelteon once daily before bedtime. 7. The method of claim 6, wherein the tasimelteon is administered at 0.5 to 1.5 hours before bedtime. 8. The method of claim 7, wherein the tasimelteon is administered at about 1 hour before bedtime. 9. The method of claim 6, further comprising: in the case that the patient is determined not to be a smoker, administering to the patient 20 mg of tasimelteon once daily before bedtime. 10. The method of claim 9, wherein the tasimelteon is administered at 0.5 to 1.5 hours before bedtime. 11. The method of claim 10, wherein the tasimelteon is administered at about 1 hour before bedtime. 12. The method of claim 6, wherein the patient is light perception impaired (LPI). 13. The method of claim 12, wherein the patient is totally blind.