Claims for Patent: 10,532,047

Summary for Patent: 10,532,047

Title:	Solid forms of ((S)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile
Abstract:	The present disclosure reports solid forms of ((S)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile.
Inventor(s):	Luke George P.
Assignee:	FORMA Therapeutics, Inc.
Application Number:	US16414716
Patent Claims:	2. The solid form of characterized by an X-ray Powder Diffraction (XRPD) having diffractions at angles (2 theta±0.2) of 6.3 claim 1 , 12.8 claim 1 , 13.8 claim 1 , 23.6 claim 1 , and 27.8 claim 1 , corresponding to d-spacing (angstroms±0.2) of 14.0 claim 1 , 6.9 claim 1 , 6.4 claim 1 , 3.8 claim 1 , and 3.2 claim 1 , respectively.3. The solid form of characterized by an X-ray Powder Diffraction (XRPD) having diffractions at angles (2 theta±0.2) of 5.7 claim 1 , 6.3 claim 1 , 8.5 claim 1 , 10.6 claim 1 , 12.8 claim 1 , 13.8 claim 1 , 17.3 claim 1 , 22.0 claim 1 , 22.8 claim 1 , 23.6 claim 1 , and 27.8.4. The solid form of characterized by an X-ray Powder Diffraction (XRPD) having diffractions at angles (2 theta±0.2) of 5.7 claim 1 , 6.3 claim 1 , 8.5 claim 1 , 10.6 claim 1 , 12.8 claim 1 , 13.8 claim 1 , 17.3 claim 1 , 22.0 claim 1 , 22.8 claim 1 , 23.6 claim 1 , and 27.8 corresponding to d-spacing (angstroms±0.2) of 15.4 claim 1 , 14.0 claim 1 , 10.4 claim 1 , 8.4 claim 1 , 6.9 claim 1 , 6.4 claim 1 , 5.1 claim 1 , 4.0 claim 1 , 3.9 claim 1 , 3.8 claim 1 , and 3.2 claim 1 , respectively.6. The solid form of characterized by a differential scanning calorimetry (DSC) thermogram with an endothermic event observed at about 256.6° C.7. The solid form of characterized by a differential scanning calorimetry (DSC) thermogram with an endothermic event observed at about 256.6° C.8. The solid form of characterized by a dynamic vapor sorption (DVS) showing maximum water uptake of 0.25% w/w at 25° C./90% RH.9. The solid form of characterized by a dynamic vapor sorption (DVS) showing maximum water uptake of 0.25% w/w at 25° C./90% RH.11. The solid form of characterized by an X-ray Powder Diffraction (XRPD) having diffractions at angles (2 theta±0.2) of 6.3 claim 10 , 12.8 claim 10 , 13.8 claim 10 , 23.6 claim 10 , and 27.8.12. The solid form of characterized by a dynamic vapor sorption (DVS) showing maximum water uptake of 0.25% w/w at 25° C./90% RH.13. The solid form of characterized by a dynamic vapor sorption (DVS) showing maximum water uptake of 0.25% w/w at 25° C./90% RH.14. A solid form of olutasidenib claim 11 , characterized by at least one of the following characteristics:(i) an X-ray Powder Diffraction (XRPD) having diffractions at angles (2 theta±0.2) of 6.3, 12.8, 13.8, 23.6, and 27.8;(ii) a differential scanning calorimetry (DSC) thermogram with an endothermic event observed at about 256.6° C.; and(iii) a dynamic vapor sorption (DVS) showing maximum water uptake of 0.25% w/w at 25° C./90% RH.15. The solid form of claim 14 , characterized by an X-ray Powder Diffraction (XRPD) having diffractions at angles (2 theta±0.2) of 6.3 claim 14 , 12.8 claim 14 , 13.8 claim 14 , 23.6 claim 14 , and 27.8 claim 14 , corresponding to d-spacing (angstroms±0.2) of 14.0 claim 14 , 6.9 claim 14 , 6.4 claim 14 , 3.8 claim 14 , and 3.2 claim 14 , respectively.16. The solid form of claim 15 , characterized by an X-ray Powder Diffraction (XRPD) having diffractions at angles (2 theta±0.2) of 5.7 claim 15 , 6.3 claim 15 , 8.5 claim 15 , 10.6 claim 15 , 12.8 claim 15 , 13.8 claim 15 , 17.3 claim 15 , 22.0 claim 15 , 22.8 claim 15 , 23.6 claim 15 , and 27.8.17. The solid form of claim 16 , characterized by an X-ray Powder Diffraction (XRPD) having diffractions at angles (2 theta±0.2) of 5.7 claim 16 , 6.3 claim 16 , 8.5 claim 16 , 10.6 claim 16 , 12.8 claim 16 , 13.8 claim 16 , 17.3 claim 16 , 22.0 claim 16 , 22.8 claim 16 , 23.6 claim 16 , and 27.8 corresponding to d-spacing (angstroms±0.2) of 15.4 claim 16 , 14.0 claim 16 , 10.4 claim 16 , 8.4 claim 16 , 6.9 claim 16 , 6.4 claim 16 , 5.1 claim 16 , 4.0 claim 16 , 3.9 claim 16 , 3.8 claim 16 , and 3.2 claim 16 , respectively.19. The solid form of claim 18 , characterized by a differential scanning calorimetry (DSC) thermogram with an endothermic event observed at about 256.6° C.20. The solid form of claim 19 , characterized by a dynamic vapor sorption (DVS) showing maximum water uptake of 0.25% w/w at 25° C./90% RH.