You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: April 25, 2024

Claims for Patent: 10,258,637


✉ Email this page to a colleague

« Back to Dashboard


Summary for Patent: 10,258,637
Title:Pharmaceutical composition, methods for treating and uses thereof
Abstract: The present invention relates to certain SGLT-2 inhibitors for treating and/or preventing metabolic disorders, such as type 1 or type 2 diabetes mellitus or pre-diabetes, in patients with renal impairment or chronic kidney disease (CKD).
Inventor(s): Broedl; Uli Christian (Mainz am Rhein, DE), Macha; Sreeraj (Basking Ridge, NJ), von Eynatten; Maximilian (Wiesbaden, DE), Woerle; Hans-Juergen (Grandvaux, CH)
Assignee: Boehringer Ingelheim International GmbH (Ingelheim am Rhein, DE)
Application Number:15/918,401
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 10,258,637
Patent Claims: 1. A method for improving glycemic control in a patient with type 2 diabetes mellitus comprising administering empagliflozin to the patient if the eGFR of the patient is .gtoreq.45 ml/min/1.73 m.sup.2 and <60 ml/min/1.73 m.sup.2, wherein empagliflozin is administered orally in a total daily amount of 5 mg, 10 mg, 12.5 mg or 25 mg, wherein the glycemic control in said patient is improved, and discontinuing empagliflozin if the eGFR of the patient falls below 45 ml/min/1.73 m.sup.2.

2. The method according to claim 1, wherein empagliflozin is administered in a total daily amount of 5 mg.

3. The method according to claim 1, wherein empagliflozin is administered in a total daily amount of 10 mg.

4. The method according to claim 1, wherein empagliflozin is administered in a total daily amount of 12.5 mg.

5. The method according to claim 1, wherein empagliflozin is administered in a total daily amount of 25 mg.

6. The method according to claim 1, further comprising administering metformin to the patient.

7. A method for improving glycemic control in a patient with type 2 diabetes mellitus comprising: a) assessing the renal function of a patient; b) administering empagliflozin to the patient if the eGFR of the patient is .gtoreq.45 ml/min/1.73 m.sup.2 and <60 ml/min/1.73 m.sup.2, wherein empagliflozin is administered orally in a total daily amount of 5 mg, 10 mg, 12.5 mg or 25 mg, wherein the glycemic control in said patient is improved; c) discontinuing empagliflozin if the eGFR of the patient falls below 45 ml/min/1.73 m.sup.2.

8. The method according to claim 7, wherein empagliflozin is administered in a total daily amount of 5 mg.

9. The method according to claim 7, wherein empagliflozin is administered in a total daily amount of 10 mg.

10. The method according to claim 7, wherein empagliflozin is administered in a total daily amount of 12.5 mg.

11. The method according to claim 7, wherein empagliflozin is administered in a total daily amount of 25 mg.

12. The method according to claim 7, further comprising administering metformin to the patient.

13. A method of treating type 2 diabetes mellitus in a patient comprising administering empagliflozin to the patient if the eGFR of the patient is .gtoreq.45 ml/min/1.73 m.sup.2 and <60 ml/min/1.73 m.sup.2, wherein empagliflozin is administered orally in a total daily amount of 5 mg, 10 mg, 12.5 mg or 25 mg, wherein the glycemic control in said patient is improved, and discontinuing empagliflozin if the eGFR of the patient falls below 45 ml/min/1.73 m.sup.2.

14. The method according to claim 13, wherein empagliflozin is administered in a total daily amount of 5 mg.

15. The method according to claim 13, wherein empagliflozin is administered in a total daily amount of 10 mg.

16. The method according to claim 13, wherein empagliflozin is administered in a total daily amount of 12.5 mg.

17. The method according to claim 13, wherein empagliflozin is administered in a total daily amount of 25 mg.

18. The method according to claim 13, further comprising administering metformin to the patient.

19. A method of treating type 2 diabetes mellitus comprising: a) assessing the renal function of a patient with type 2 diabetes mellitus; b) administering empagliflozin to the patient if the eGFR of the patient is .gtoreq.45 ml/min/1.73 m.sup.2 and <60 ml/min/1.73 m.sup.2, wherein empagliflozin is administered orally in a total daily amount of 5 mg, 10 mg, 12.5 mg or 25 mg, wherein the glycemic control in said patient is improved; c) discontinuing empagliflozin if the eGFR of the patient falls below 45 ml/min/1.73 m.sup.2.

20. The method according to claim 19, wherein empagliflozin is administered in a total daily amount of 5 mg.

21. The method according to claim 19, wherein empagliflozin is administered in a total daily amount of 10 mg.

22. The method according to claim 19, wherein empagliflozin is administered in a total daily amount of 12.5 mg.

23. The method according to claim 19, wherein empagliflozin is administered in a total daily amount of 25 mg.

24. The method according to claim 19, further comprising administering metformin to the patient.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.