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Last Updated: April 19, 2024

Claims for Patent: 10,130,636

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Summary for Patent: 10,130,636

Title:	High dosage strength tablets of rucaparib
Abstract:	A tablet including high dosage of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[- 5,4,3-cd]indol-6-one camsylate salt has been disclosed.
Inventor(s):	Etter; Jeffrey (Boulder, CO)
Assignee:	Clovis Oncology, Inc. (Boulder, CO)
Application Number:	15/920,643
Patent Claims:	1. A method of treating cancer in a mammal, the method comprising administering to the mammal a therapeutically effective amount of a tablet comprising 45-90% w/w of an active pharmaceutical ingredient compound 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H- -azepino[5,4,3-cd]indol-6-one camsylate. 2. The method according to claim 1, wherein the active pharmaceutical ingredient is included in the range of 50-90%. 3. The method according to claim 1, wherein the active pharmaceutical ingredient is included in the range of 55-90%. 4. The method according to claim 1, wherein the active pharmaceutical ingredient is included in the range of 60-90%. 5. The method according to claim 1, wherein the active pharmaceutical ingredient is included in the range of 65-85%. 6. The method according to claim 1, wherein the active pharmaceutical ingredient is included in the range of 70-80%. 7. The method according to claim 1, wherein the tablet includes 200 mg or more of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-- azepino[5,4,3-cd]indol-6-one. 8. The method according to claim 1, wherein the tablet includes 250 mg or more of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-- azepino[5,4,3-cd]indol-6-one. 9. The method according to claim 1, wherein the tablet includes 300 mg or more of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-- azepino[5,4,3-cd]indol-6-one. 10. The method according to claim 1, wherein the mammal is a human being. 11. A method of treating cancer in a mammal, the method comprising administering to the mammal a therapeutically effective amount of a dry granulated tablet comprising 45-90% w/w of an active pharmaceutical ingredient compound 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[- 5,4,3-cd]indol-6-one camsylate, wherein the tablet includes 200 mg or more of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepi- no[5,4,3-cd]indol-6-one.

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