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Last Updated: December 12, 2025

Acetic acid, glacial - Generic Drug Details


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What are the generic drug sources for acetic acid, glacial and what is the scope of freedom to operate?

Acetic acid, glacial is the generic ingredient in fifteen branded drugs marketed by Actavis Mid Atlantic, Chartwell Rx, Kv Pharm, Rising, Sciegen Pharms Inc, Sun Pharma Canada, Warner Chilcott, Hikma, B Braun, Baxter Hlthcare, Otsuka Icu Medcl, Bausch And Lomb, Pharmafair, Bayer Pharms, Cosette, Taro, Wockhardt, and Saptalis Pharms, and is included in twenty-four NDAs. Additional information is available in the individual branded drug profile pages.

Seven suppliers are listed for this compound.

Summary for acetic acid, glacial
Recent Clinical Trials for acetic acid, glacial

Identify potential brand extensions & 505(b)(2) entrants

SponsorPhase
National Institute of PerinatologyPhase 4
National Council of Science and Technology, MexicoPhase 4

See all acetic acid, glacial clinical trials

US Patents and Regulatory Information for acetic acid, glacial

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Sun Pharma Canada ACETIC ACID acetic acid, glacial SOLUTION/DROPS;OTIC 088638-001 Sep 6, 1984 DISCN No No ⤷  Get Started Free ⤷  Get Started Free ⤷  Get Started Free
Saptalis Pharms VOSOL HC acetic acid, glacial; hydrocortisone SOLUTION/DROPS;OTIC 012770-001 Approved Prior to Jan 1, 1982 AT RX Yes Yes ⤷  Get Started Free ⤷  Get Started Free ⤷  Get Started Free
Chartwell Rx ACETIC ACID acetic acid, glacial SOLUTION/DROPS;OTIC 040166-001 Jul 26, 1996 DISCN No No ⤷  Get Started Free ⤷  Get Started Free ⤷  Get Started Free
B Braun ACETIC ACID 0.25% IN PLASTIC CONTAINER acetic acid, glacial SOLUTION;IRRIGATION, URETHRAL 018161-001 Approved Prior to Jan 1, 1982 AT RX No No ⤷  Get Started Free ⤷  Get Started Free ⤷  Get Started Free
Kv Pharm ACETIC ACID acetic acid, glacial SOLUTION/DROPS;OTIC 085493-001 Approved Prior to Jan 1, 1982 DISCN No No ⤷  Get Started Free ⤷  Get Started Free ⤷  Get Started Free
Pharmafair BOROFAIR acetic acid, glacial; aluminum acetate SOLUTION/DROPS;OTIC 088606-001 Aug 21, 1985 DISCN No No ⤷  Get Started Free ⤷  Get Started Free ⤷  Get Started Free
Warner Chilcott ORLEX HC acetic acid, glacial; hydrocortisone SOLUTION/DROPS;OTIC 086844-001 Approved Prior to Jan 1, 1982 DISCN No No ⤷  Get Started Free ⤷  Get Started Free ⤷  Get Started Free
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

Market Dynamics and Financial Trajectory for Glacial Acetic Acid

Last updated: July 29, 2025

Introduction

Glacial acetic acid, a highly concentrated form of acetic acid with a purity of 99.5% or higher, holds a pivotal role across multiple industrial sectors. From its conventional use in the manufacture of vingear and food preservatives to its critical application in chemical synthesis, its significance extends into plastics, textiles, and various industrial processes. Understanding the market dynamics and financial potential of glacial acetic acid involves examining supply-demand trends, regulatory influences, manufacturing economics, and key industry drivers shaping its growth trajectory.

Market Overview

Globally, the glacial acetic acid market is experiencing steady growth, attributed primarily to surges in the chemical, food, and textile industries. The Asia-Pacific region dominates the market, benefiting from rapid industrialization, expanding manufacturing bases, and a thriving textile sector. According to recent industry reports, the global acetic acid market was valued at approximately USD 10.5 billion in 2022, with projections indicating a compound annual growth rate (CAGR) of around 4% over the next five years, partly driven by increased demand for acetic acid derivatives.

Glacial acetic acid accounts for a significant share within this market, especially in regions where high-purity chemicals are in demand for specialized applications, including pharmaceuticals and laboratory reagents. Its high purity and reactive properties make it indispensable in the manufacture of acetic anhydride, vinyl acetate monomer, and acetate esters—core components in producing paints, adhesives, and coatings.

Key Market Drivers

1. Expansion of Vinyl Acetate Monomer (VAM) Production

Vinyl acetate monomer is a dominant derivative of glacial acetic acid, critical in manufacturing emulsion polymers used for adhesives, paints, and textiles. The soaring demand for VAM—particularly in end-use industries like construction and automotive—directly correlates to increased acetic acid consumption. The growth of the construction industry in emerging economies such as China and India further propels this demand.

2. Growing Pharmaceutical and Food Industry Applications

High-purity glacial acetic acid is a vital chemical in pharmaceutical synthesis, including production of acetic anhydride and other intermediates. Additionally, regulations favor natural preservatives, elevating the role of acetic acid derivatives in food preservation and flavoring, bolstering its market growth.

3. Surge in Packaging and Adhesive Industries

The expansion of packaging materials and adhesive formulations, particularly in Asia-Pacific, is pushing demand for acetic acid derivatives as raw materials. The trend toward eco-friendly and high-performance adhesives aligns with the chemical’s properties.

4. Advancements in Manufacturing Technologies

Innovations in production processes—such as methanol carbonylation and catalytic oxidation—have enhanced yields, reduced costs, and improved safety profiles, thus making the supply chain more resilient and cost-effective, benefiting market growth.

Market Challenges

1. Environmental and Regulatory Constraints

Regulatory frameworks concerning the handling, transportation, and emissions of acetic acid present barriers to market expansion. Stringent environmental standards in Europe and North America can restrict manufacturing operations or supply chain flexibility.

2. Fluctuations in Raw Material Prices

The cost of methanol and acetylene, primary raw materials for acetic acid synthesis, significantly influences production economics. Volatility in these prices, driven by global energy prices or supply disruptions, can impact profitability.

3. Competition from Bio-Based Alternatives

Emerging bio-based chemicals pose potential competition to traditional petrochemical routes, though currently their commercial scale remains limited.

Supply Chain and Manufacturing Dynamics

Major producers of glacial acetic acid—such as Celanese Corporation, Eastman Chemical Company, and Anhui Wanli Chemical Co.—operate via acetic acid manufacturing facilities primarily based on methanol carbonylation processes, which offer high efficiency and scalability. The capacity expansion plans from these industry players aim to meet rising global demand.

Additionally, regional hubs facilitate logistics and distribution, with Asia-Pacific accounting for approximately 50% of global production capacity, followed by North America and Europe. Trade policies, tariffs, and import-export regulations critically influence market accessibility and pricing mechanisms.

Financial Trajectory and Investment Outlook

The financial outlook for glacial acetic acid rests on several key factors:

  • Cost Structure Optimization: Advancements in catalytic processes and economies of scale are lowering production costs. Manufacturers focusing on cost-effective, environmentally friendly processes are better positioned for profitability.

  • Price Volatility: The acetic acid market exhibits susceptibility to raw material price fluctuations, impacting margins. Contract-based procurement strategies and strategic raw material hedging are common risk mitigation tools.

  • Demand Elasticity: As demand from major downstream sectors remains robust, revenues are expected to grow consonant with industrial activity. However, shifts toward bio-based chemicals and regulatory restrictions could influence pricing power.

  • Investment Trends: There is a notable uptick in investments toward capacity expansion and technological innovation, especially in Asian markets. These investments aim to capitalize on projected demand growth and sustain competitive positioning.

  • Environmental & Regulatory Costs: Stricter environmental standards may result in increased capital expenditures for compliance but also foster the adoption of cleaner production technologies that could enhance long-term profitability.

Regional Market Considerations

Asia-Pacific

The region leads on account of high-demand end-use sectors, large manufacturing base, and expanding disposable incomes. Rapid urbanization and infrastructure development accelerate the need for chemical intermediates derived from acetic acid.

North America

Market stability benefits from mature chemical manufacturing infrastructure and stringent environmental regulations, which incentivize cleaner process technologies. Demand is correlated with recovery in construction and automotive industries post-pandemic.

Europe

Confronted with strict regulations and a shift toward sustainable chemicals, European producers focus on process innovations and green chemistry initiatives—potentially influencing profitability and market share.

Future Market Opportunities

Emerging trends for glacial acetic acid encompass the development of bio-based production processes, integrating renewable feedstocks like biomass-derived methanol. Additionally, growth in niche applications such as specialty coatings, pharmaceuticals, and electronics manufacturing expand the market scope.

Investments in research for enhanced catalytic processes, waste minimization, and greener production methods are likely to facilitate higher profit margins and market resilience. Additionally, strategic partnerships and capacity-sharing initiatives in high-growth regions will shape the competitive landscape.

Key Takeaways

  • Market growth remains steady, driven by demand from downstream industries such as VAM production, pharmaceuticals, and food preservation.
  • Asia-Pacific dominates the supply chain, owing to rapid industrialization and expanding manufacturing sectors.
  • Environmental regulations pose operational challenges, but technological advancements offer pathways for cost reduction and cleaner production.
  • Raw material price volatility significantly influences manufacturing economics, necessitating strategic procurement.
  • Investment in capacity expansions and green technologies indicates a positive outlook, ensuring long-term profitability amid evolving regulatory and market landscapes.

Conclusion

The market for glacial acetic acid is poised for sustained growth, contingent upon technological innovation, regional economic developments, and evolving regulatory frameworks. Stakeholders who prioritize supply chain efficiency, environmental compliance, and diversification into bio-based processes will better leverage emerging opportunities and mitigate associated risks.


FAQs

1. What are the primary applications of glacial acetic acid?
Glacial acetic acid is mainly used in producing vinyl acetate monomer, acetic anhydride, and acetate esters. It also serves in pharmaceuticals, food preservation, and manufacturing of adhesives and paints.

2. How does regional manufacturing capacity impact the global market?
Regions with high capacities, such as Asia-Pacific, influence global supply and pricing dynamics, enabling supply chain resilience and reducing logistics costs. These capacities also attract investment, further amplifying regional market influence.

3. What are emerging trends influencing the future of glacial acetic acid?
Key trends include the adoption of bio-based production methods, process innovations for sustainability, and increasing applications in specialty chemicals and electronics manufacturing.

4. How do raw material prices affect the profitability of acetic acid producers?
Fluctuations in methanol and acetylene prices directly impact production costs. Producers often hedge raw material costs and seek technological efficiencies to maintain margins amid price volatility.

5. What are the environmental considerations associated with glacial acetic acid manufacturing?
Strict environmental regulations require adherence to emission standards, waste management, and safety protocols. Companies investing in cleaner, more efficient technologies can reduce compliance costs and enhance corporate sustainability profiles.


Sources

[1] Industry reports and market research from MarketsandMarkets, 2022.
[2] Company quarterly and annual financial disclosures.
[3] Environmental and safety standards from the European Chemicals Agency (ECHA).
[4] Chemical production technology literature.

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