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Generated: May 25, 2018

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Pemetrexed disodium - Generic Drug Details

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What are the generic sources for pemetrexed disodium and what is the scope of pemetrexed disodium patent protection?

Pemetrexed disodium
is the generic ingredient in one branded drug marketed by Lilly and is included in one NDA. There is one patent protecting this compound and four Paragraph IV challenges. Additional information is available in the individual branded drug profile pages.

Pemetrexed disodium has seventeen patent family members in eleven countries.

There are twenty-nine drug master file entries for pemetrexed disodium. One supplier is listed for this compound. There are two tentative approvals for this compound.
Pharmacology for pemetrexed disodium
Medical Subject Heading (MeSH) Categories for pemetrexed disodium
Synonyms for pemetrexed disodium
(2S)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid
(2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)phenyl]formamido}pentanedioic acid
(S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo-[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid
(S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic
(S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid
(S)-2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid
04Q9AIZ7NO
137281-23-3
150399-23-8
1juj
2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID
281P233
2PKU919BA9
357166-30-4
41413-EP2270012A1
41413-EP2270013A1
41413-EP2305681A1
41413-EP2311838A1
41421-EP2270012A1
41421-EP2270013A1
41421-EP2305681A1
41421-EP2311838A1
4DW
89077-EP2270012A1
89077-EP2270013A1
89077-EP2305681A1
AB01273937-01
AC-1326
AC-1701
AC1L9JT6
AC1OCF51
AJ-26845
AK-72902
AK325951
AKOS015896253
AKOS025149477
AKOS025392176
Alimta
Alimta (TN) (Lilly)
BC215781
BDBM18796
BDBM50027656
BG0632
BR-72902
C20H19N5Na2O6
C20H19N5O6.2Na.7H2O
C20H21N5O6
CAS-150399-23-8
CCG-213071
CCG-221272
CHEBI:63616
CHEBI:63722
CHEMBL225072
CHEMBL2360464
CP0067
CP0119
CS-1297
CS-1298
CS-W004541
CTK8E6673
D03828
D07472
DB-024764
DB00642
disodium (2S)-2-({4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}amino)pentanedioate
disodium (2S)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate
Disodium N-(p-(2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl)-L-glutamate
disodium N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate
DSSTox_CID_26660
DSSTox_GSID_46660
DSSTox_RID_81803
DTXSID2048329
DTXSID8046660
EX-A836
FT-0659328
H518
HMS3264H07
HSDB 7316
HY-10820
HY-10820A
I06-2128
J-502393
KB-78231
KB-79792
KS-00000GW0
KS-00000XJK
KS-5001
L-Glutamic acid, N-(4-(2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl)-
L-Glutamic acid,3-d]pyrimidin-5-yl]ethyl]benzoyl]-
LY-2315
LY-231514
LY231514
LY231514 disodium
LYA
MolPort-003-849-796
MolPort-016-638-470
MolPort-020-179-988
N-(4-[2-(2-amino-4,7-Dihydro-4-Oxo-1H-Pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl)-L-Glutamic Acid
N-(4-[2-(2-Amino-4,7-Dihydro-4-Oxo-1H-Pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl)-L-Glutamic Acid Disodium Salt
N-(4-[2-(2-Amino-4,7-Dihydro-4-Oxo-1H-Pyrrolo[2,3-d]pyrimidin-5yl)ethyl]benzoyl)-L-Glutamic Acid Disodium Salt
N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7h-pyrrolo[2,3-d]pyrimi-din-5-yl)ethyl]benzoyl]l-glutamic acid
N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2.3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt
N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid
N-[4-[2-[2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl]ethyl]benzoyl]glutamic acid
N-[4-[2(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo [2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid
N-[4-[2(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid
N-[4[2-(-amino-3,4-dihydro-4-oxo-7h-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamate sodium salt
N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid
N-{4-[2-(2-Amino-4-Oxo-4,7-Dihydro-3h-Pyrrolo[2,3-D]pyrimidin-5-Yl)ethyl]benzoyl}-L-Glutamic Acid
NCGC00167486-01
NCGC00167517-01
NCGC00242485-01
NSC-698037
NSC698037
NYDXNILOWQXUOF-GXKRWWSZSA-L
P2288
Pemetrexed
Pemetrexed (disodium)
Pemetrexed (INN)
Pemetrexed (TN)
Pemetrexed acid
pemetrexed diacid monohydrate
Pemetrexed disodium (USAN)
Pemetrexed disodium [USAN]
PEMETREXED DISODIUM 5/2 hydrate
Pemetrexed disodium salt
Pemetrexed disodium, anhydrous
Pemetrexed Na
Pemetrexed Sodium
Pemetrexed sodium hydrate
Pemetrexeddisodium
Premetred disodium
Premetrexed [Common mis-spelling]
Rolazar
RP17940
RP17947
S-4927
s1135
SC-25136
SCHEMBL18348
SCHEMBL7968
sodium (S)-2-(4-(2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate
Tifolar
Tox21_112487
UNII-04Q9AIZ7NO
UNII-2PKU919BA9
WBXPDJSOTKVWSJ-ZDUSSCGKSA-N
X5918
ZINC1540998
Tentative approvals for PEMETREXED DISODIUM
Applicant Application No. Strength Dosage Form
➤ Try a Free Trial➤ Try a Free Trial100MGINJECTABLE;INJECTION
➤ Try a Free Trial➤ Try a Free Trial500MGINJECTABLE;INJECTION
➤ Try a Free Trial➤ Try a Free Trial100MGINJECTABLE;INJECTION

US Patents and Regulatory Information for pemetrexed disodium

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Lilly ALIMTA pemetrexed disodium INJECTABLE;IV (INFUSION) 021462-002 Sep 7, 2007 RX Yes Yes ➤ Try a Free Trial ➤ Try a Free Trial Y ➤ Try a Free Trial
Lilly ALIMTA pemetrexed disodium INJECTABLE;IV (INFUSION) 021462-001 Feb 4, 2004 RX Yes Yes ➤ Try a Free Trial ➤ Try a Free Trial Y ➤ Try a Free Trial
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration

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Expired US Patents for pemetrexed disodium

Applicant Tradename Generic Name Dosage NDA Approval Date Patent No. Patent Expiration
Lilly ALIMTA pemetrexed disodium INJECTABLE;IV (INFUSION) 021462-001 Feb 4, 2004 ➤ Try a Free Trial ➤ Try a Free Trial
Lilly ALIMTA pemetrexed disodium INJECTABLE;IV (INFUSION) 021462-002 Sep 7, 2007 ➤ Try a Free Trial ➤ Try a Free Trial
Lilly ALIMTA pemetrexed disodium INJECTABLE;IV (INFUSION) 021462-001 Feb 4, 2004 ➤ Try a Free Trial ➤ Try a Free Trial
Lilly ALIMTA pemetrexed disodium INJECTABLE;IV (INFUSION) 021462-002 Sep 7, 2007 ➤ Try a Free Trial ➤ Try a Free Trial
Applicant Tradename Generic Name Dosage NDA Approval Date Patent No. Patent Expiration

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Non-Orange Book US Patents for pemetrexed disodium

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
7,053,065 Vitamin B12 and pemetrexed disodium combination therapies ➤ Try a Free Trial
Patent No. Title Estimated Patent Expiration

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Supplementary Protection Certificates for pemetrexed disodium

Supplementary Protection Certificate SPC Country SPC Expiration SPC Description
C/GB05/011 United Kingdom ➤ Try a Free Trial PRODUCT NAME: PEMETREXED AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF; REGISTERED: UK EU/1/04/290/001 20040920
2005 Austria ➤ Try a Free Trial PRODUCT NAME: PEMETREXED UND DESSEN PHARMAZEUTISCH ANNAHMBAREN SALZE; REGISTRATION NO/DATE: EU/1/04/290/001 20040920
Supplementary Protection Certificate SPC Country SPC Expiration SPC Description

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Julphar
McKinsey
Queensland Health
Deloitte
McKesson
Farmers Insurance
Healthtrust
Federal Trade Commission
Covington

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