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Chinese Patent Office
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Covington
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Baxter
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Mallinckrodt

Generated: April 19, 2018

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Levoleucovorin calcium - Generic Drug Details

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What are the generic drug sources for levoleucovorin calcium and what is the scope of levoleucovorin calcium patent protection?

Levoleucovorin calcium
is the generic ingredient in two branded drugs marketed by Spectrum Pharms, Actavis Llc, Amneal Pharms Co, West-ward Pharms Int, Mylan Teoranta, and Sandoz Inc, and is included in eight NDAs. There is one patent protecting this compound and two Paragraph IV challenges. Additional information is available in the individual branded drug profile pages.

Levoleucovorin calcium has twenty-one patent family members in nine countries.

There is one drug master file entry for levoleucovorin calcium. Six suppliers are listed for this compound.
Summary for levoleucovorin calcium
Medical Subject Heading (MeSH) Categories for levoleucovorin calcium
Synonyms for levoleucovorin calcium
(+)-L-Folinic acid, calcium salt
(S)-5-FORMYL-5,6,7,8-TETRAHYDROFOLIC ACID CALCIUM SALT
1236362-90-5
1492-18-8
30771-29-0
58-05-9 (Parent)
6035-45-6
6209-45-6
778XL6VBS8
80433-71-2
A839909
AB2000681
AC-24017
AC-7456
AC1L259Q
AC1L9FEF
AKOS015894859
AKOS025401656
AKOS032949578
AN-36399
AN-9009
AOB5605
API0001819
AS-13746
BIC0607
C20H21N7O7.Ca
Calcii folinas
Calcii folinas [INN-Latin]
calcium (2S)-2-[[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]phenyl]-oxomethyl]amino]pentanedioate
calcium (2S)-2-[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate
calcium (2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
calcium (2S)-2-[[4-[[(6S)-2-azanyl-5-methanoyl-4-oxidanylidene-1,6,7,8-tetrahydropteridin-6-yl]methylamino]phenyl]carbonylamino]pentanedioate
calcium (6s)-folinate
Calcium 5-formyltetrahydrofolate
Calcium citrovorum factor
Calcium folinatc
calcium folinate
Calcium folinate (JP17)
Calcium folinate [INN]
Calcium folinate, 98% 250mg
Calcium Folinate, USP
Calcium folinate(Leucovorin Calcium)
Calcium L-folinate
Calcium leucovorin
Calcium levofolinate
Calcium levofolinate (Calcium Folinate)
Calcium levofolinate (INN)
Calcium N-(p-((((6RS)-2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamate (1:1)
Calcium N-(p-((((6S)-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamate (1:1)
calcium;(2S)-2-[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate
calcium(2+) (2S)-2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioate
Calciumlevofolinate
CC0139
CCG-38930
CHEBI:31340
CHEMBL1201138
CHEMBL1908361
CL 307,782
CL-307782
CS-1363
CS-2466
D01211
D04715
D0B6TW
D0Q6LA
D0V7RH
DTXSID20872448
DTXSID3045564
EINECS 216-082-8
Elvorine
Elvorine|||Isovorin|||Calcium (2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
F-7000
Folidan
Folinate de calcium
Folinate de calcium [INN-French]
Folinate-SF Calcium
Folinato calcico
Folinato calcico [INN-Spanish]
Folinic acid (Calcium)
Folinic acid calcium salt
Folinic acid l-form calcium salt
Folinic acid-SF, calcium salt
FT-0603241
FT-0603561
FT-0654951
Fusilev
Fusilev (TN)
Glutamic acid, N-(p-(((2-amino-5-formyl-5,6,7,8-tetrahydro-3-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-, calcium salt (1:1), L-
HE313049
HMS1570C18
HMS1920J05
HMS2091P21
HMS2097C18
HMS500L04
HY-13664
HY-13667
I06-116
Isovorin
Isovorin (TN)
KVUAALJSMIVURS-ZEDZUCNESA-L
L-Glutamic acid, N-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-, calcium salt (1:1)
L-Glutamic acid, N-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-, calcium salt (1:1), (S)-
L-Leucovorin calcium
Lederfoline
LEUCOVORIN CALCIUM
Leucovorin calcium (USP)
Leucovorin Calcium [USAN]
Leucovorin calcium [USP]
Leucovorin calcium preservative free
Leucovorin calcium salt
Levofolinate calcium (JAN)
Levoleucovorin (Calcium)
Levoleucovorin calcium (USAN)
Levoleucovorin calcium [USAN]
Levoleukovorin calcium
LS-71774
MFCD08704249
MolPort-003-666-218
MolPort-020-001-403
NSC 3590
Prestwick_224
Rescuvolin
RL01892
SCHEMBL18573
SCHEMBL467144
SCHEMBL9340225
SPECTRUM1500364
UNII-778XL6VBS8
UNII-RPR1R4C0P4 component KVUAALJSMIVURS-QNTKWALQSA-L
Uzel (TN)
W-60274
Wellcovorin
Wellcovorin (TN)

US Patents and Regulatory Information for levoleucovorin calcium

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Spectrum Pharms FUSILEV levoleucovorin calcium SOLUTION;IV (INFUSION) 020140-002 Apr 29, 2011 DISCN Yes No ➤ Try a Free Trial ➤ Try a Free Trial ➤ Try a Free Trial
Spectrum Pharms FUSILEV levoleucovorin calcium POWDER;IV (INFUSION) 020140-001 Mar 7, 2008 AP RX Yes Yes ➤ Try a Free Trial ➤ Try a Free Trial Y Y ➤ Try a Free Trial
Sandoz Inc LEVOLEUCOVORIN CALCIUM levoleucovorin calcium SOLUTION;IV (INFUSION) 203563-002 Mar 9, 2015 AP RX No Yes ➤ Try a Free Trial ➤ Try a Free Trial ➤ Try a Free Trial
Spectrum Pharms FUSILEV levoleucovorin calcium SOLUTION;IV (INFUSION) 020140-002 Apr 29, 2011 DISCN Yes No ➤ Try a Free Trial ➤ Try a Free Trial Y Y ➤ Try a Free Trial
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration

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Non-Orange Book US Patents for levoleucovorin calcium

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
4,959,472 Process for preparing substantially pure diastereoisomers of tetrahydrofolic derivatives ➤ Try a Free Trial
6,849,628 Optically active compounds ➤ Try a Free Trial
Patent No. Title Estimated Patent Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

UBS
Colorcon
Johnson and Johnson
AstraZeneca
Federal Trade Commission
US Army
Healthtrust
Covington
Baxter

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