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Etomidate - Generic Drug Details

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What are the generic drug sources for etomidate and what is the scope of etomidate freedom to operate?

Etomidate is the generic ingredient in two branded drugs marketed by Hospira, Aurobindo Pharma Ltd, Emcure Pharms Ltd, Gland Pharma Ltd, Hikma Farmaceutica, Luitpold, Mylan Labs Ltd, Par Sterile Products, West-ward Pharms Int, and Zydus Pharms Usa Inc, and is included in eleven NDAs. Additional information is available in the individual branded drug profile pages.

There are six drug master file entries for etomidate. Twelve suppliers are listed for this compound.

Summary for etomidate

US Patents:	0
Tradenames:	2
Applicants:	10
NDAs:	11
Drug Master File Entries:	6
Suppliers / Packagers:	12
Bulk Api Vendors:	129
Clinical Trials:	54
Patent Applications:	3,947
Formulation / Manufacturing:	see details
DailyMed Link:	etomidate at DailyMed

Pharmacology for etomidate

Drug Class	General Anesthetic
Physiological Effect	General Anesthesia

Medical Subject Heading (MeSH) Categories for etomidate

Anesthetics, Intravenous

Hypnotics and Sedatives

Synonyms for etomidate

(-)-ethyl 1-(1-phenylethyl)-1H-imidazole- 5-carboxylate

(-)-ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate

(?)-Etomidate

(+)-Ethyl 1-(.alpha.-methylbenzyl)imidazole-5-carboxylate

(+)-Ethyl 1-(alpha-methylbenzyl)imidazole-5-carboxylate

(+)-Etomidate

(d)-Etomidate

(R)-(+)-1-(.alpha.-Methylbenzyl)imidazole-5-carboxylic acid ethyl ester

(R)-(+)-1-(1-Phenylethyl)-1H-imidazole-5-carboxylic Acid Ethyl Ester

(R)-(+)-1-(alpha-Methylbenzyl)imidazole-5-carboxylic acid ethyl ester

(R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester

(R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylicacid ethyl ester

(R)-ETHYL 1-(1-PHENYLETHYL)-1H-IMIDAZOLE-5-CARBOXYLATE

[R,(+)]-1-(alpha-Methylbenzyl)-1H-imidazole-5-carboxylic acid ethyl ester

1-(.alpha.-Methylbenzyl)-1H-imidazole-5-carboxylic acid ethyl ester

1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester

1-(1-Phenylethyl)-imidazole-5-carboxylic acid, ethyl ester

1-(alpha-Methylbenzyl)-1H-imidazole-5-carboxylic acid ethyl ester

125E972

15301-65-2

1H-Imidazole-5-carboxylic acid, 1-(.alpha.-methylbenzyl)-, ethyl ester, (+)-

1H-Imidazole-5-carboxylic acid, 1-((1R)-1-phenylethyl)-, ethyl ester

1H-Imidazole-5-carboxylic acid, 1-(1-phenylethyl)-, ethyl ester, (+-)-

1H-Imidazole-5-carboxylic acid, 1-(1-phenylethyl)-, ethyl ester, (+)-

1H-Imidazole-5-carboxylic acid, 1-(1-phenylethyl)-, ethyl ester, (R)-

1H-Imidazole-5-carboxylic acid, 1-(1-phenylethyl)-, ethyl ester, (R)- [CAS]

1H-Imidazole-5-carboxylic acid, 1-[(1R)-1-phenylethyl]-, ethyl ester

1H-Imidazole-5-carboxylic acid, 1-[(1S)-1-phenylethyl]-, ethyl ester

2403AH

3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic acid ethyl ester

3-((S)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic acid ethyl ester

3-(1-Phenyl-ethyl)-3H-imidazole-4-carboxylic acid ethyl ester

3-[(1R)-1-phenylethyl]-4-imidazolecarboxylic acid ethyl ester

33125-97-2

4CH-007314

56649-47-9

A821630

AB0012165

AB00439988_13

AB00439988-11

AB00514014

AB00639951_06

AB2000049

Absele

AC-5898

AC1L1VLF

AC1LDI6L

AC1O3UGO

AC1Q34BV

AC1Q64LP

AJ-08018

AK-49072

AKOS000548952

AKOS015920052

AKOS021628930

AKOS030240711

AM803710

Amidate

Amidate (pharmaceutical)

Amidate (TN)

Amidate, Etomidate

AN-379

AX8129871

BAS 01947657

BC203897

BDBM238149

BDBM50125935

BDBM50125937

BG0367

Bio-0779

BPBio1_001060

BR-49072

BRN 0665833

BSPBio_000962

C07522

C14H16N2O2

CAS-33125-97-2

CCG-101054

CCG-221041

CHEBI:4910

CHEBI:91759

CHEBI:95268

CHEMBL23731

CHEMBL279678

CHEMBL681

CPD000010931

CPD000466277

CS-1833

CTK1F4139

CTK6F7213

D-Etomidate

D00548

D02YPG

DB00292

DR000607

DSSTox_CID_3033

DSSTox_GSID_23033

DSSTox_RID_76841

DTXSID5023033

E0897

EINECS 251-385-9

EN300-50290

Ethnor

Ethomidate

Ethyl (R)-(+)-1-(1-Phenylethyl)-1H-imidazole-5-carboxylate

ethyl (R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylate

Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate

Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate, (+)-

ethyl 1-(phenylethyl)imidazole-5-carboxylate

ethyl 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylate

ethyl 3-(1-phenylethyl)imidazole-4-carboxylate

ethyl 3-[(1R)-1-phenylethyl]imidazole-4-carboxylate

ethyl 3-[(1S)-1-phenylethyl]imidazole-4-carboxylate

Etomidate (USAN/INN)

Etomidate [USAN:BAN:INN]

Etomidate [USAN:USP:INN:BAN]

Etomidate 0.1 mg/ml in Methanol

Etomidate 1.0 mg/ml in Methanol

Etomidate, >98% (HPLC), powder

Etomidate, European Pharmacopoeia (EP) Reference Standard

Etomidate, United States Pharmacopeia (USP) Reference Standard

Etomidato

Etomidato [INN-Spanish]

Etomidatum

Etomidatum [INN-Latin]

Etomidic acid

FT-0630568

GS-3208

GTPL5463

HE214131

HE313963

HE335680

HMS1571A04

HMS1612G10

HMS2051P18

HMS2093P17

HMS2098A04

HMS2232A08

HMS2234K12

HMS2235K14

HMS3259F15

HMS3267N06

HMS3369P19

HMS3371K15

HMS3393P18

HMS3428L14

HMS3654N15

HY-B0100

Hypnomidate

Imidazole-5-carboxylic acid, 1-(.alpha.-methylbenzyl)-, ethyl ester, (R)-(+)-

Imidazole-5-carboxylic acid, 1-(alpha-methylbenzyl)-, ethyl ester, (R)-(+)-

J10465

KB-51833

KS-00000G8T

LS-78232

MCULE-8274432743

MFCD00869295

MLS000034952

MLS000758268

MLS001240191

MLS001424163

MLS002154118

MLS006011948

MolPort-000-917-569

MolPort-003-983-475

NC00304

NC00657

NCGC00016817-01

NCGC00016817-02

NCGC00025176-01

NCGC00025176-02

NE51441

NPUKDXXFDDZOKR-UHFFFAOYSA-N

NSC-759160

NSC759160

Opera_ID_1830

Pharmakon1600-01505599

Prestwick0_001041

Prestwick1_001041

Prestwick2_001041

Prestwick3_001041

PubChem6027

Q-201102

R 16659

R 26490

R-(+) ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate

R-(+)-Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate

r-(+)-ethyl-1-(1-phenylethyl)-1h-imidazole-5-carboxylate

R-(+)-etomidate

R-16659

R-26490

R-ETOMIDATE

R(+)-etomidate

R16659

R26490

Radenarcon

Radenarkon

RL03203

S-(-)-Etomidate

S-3872

S-ETOMIDATE

S(-)-Etomidate

s1329

SAM001247074

SAM002548930

SBB066197

SBI-0206822.P001

SC-03534

SCHEMBL39485

SCHEMBL39486

SCHEMBL39487

SMR000010931

SMR000466277

SMR001233425

SPBio_002901

SR-01000325781

SR-01000325781-1

ST2413089

Tox21_110628

Tox21_110628_1

UNII-Z22628B598

US9394290, ETO (etomidate)

VA10867

Z22628B598

Z802671476

ZB000327

ZINC1408

ZINC17364045

US Patents and Regulatory Information for etomidate

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
West-ward Pharms Int	ETOMIDATE	etomidate	INJECTABLE;INJECTION	074593-001	Nov 4, 1996	AP	RX	No	No
Zydus Pharms Usa Inc	ETOMIDATE	etomidate	INJECTABLE;INJECTION	202360-001	Jul 18, 2014	AP	RX	No	No
Emcure Pharms Ltd	ETOMIDATE	etomidate	INJECTABLE;INJECTION	204618-001	Aug 13, 2014	AP	RX	No	No
Aurobindo Pharma Ltd	ETOMIDATE	etomidate	INJECTABLE;INJECTION	206126-001	Feb 24, 2017	AP	RX	No	No

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