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Adenosine - Generic Drug Details

What are the generic drug sources for adenosine and what is the scope of adenosine patent protection?
Adenosine is the generic ingredient in three branded drugs marketed by Astellas, Akorn, Fresenius Kabi Usa, Gland Pharma Ltd, Luitpold, Mylan Labs Ltd, Teva Pharms Usa, West-ward Pharms Int, Wockhardt, Aurobindo Pharma Ltd, Emcure Pharms Ltd, Hospira Inc, and Mylan Asi, and is included in twenty-three NDAs. Additional information is available in the individual branded drug profile pages.

There are twenty-six drug master file entries for adenosine. Eighteen suppliers are listed for this compound. There are three tentative approvals for this compound.

Summary for adenosine

US Patents:	0
Tradenames:	3
Applicants:	13
NDAs:	23
Drug Master File Entries:	26
Suppliers / Packagers:	18
Bulk Api Vendors:	110
Clinical Trials:	383
Patent Applications:	7,255
Formulation / Manufacturing:	see details
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for adenosine
DailyMed Link:	adenosine at DailyMed

Pharmacology for adenosine

Drug Class	Adenosine Receptor Agonist
Mechanism of Action	Adenosine Receptor Agonists

Medical Subject Heading (MeSH) Categories for adenosine

Analgesics
Anti-Arrhythmia Agents
Purinergic P1 Receptor Agonists
Vasodilator Agents

Synonyms for adenosine

.beta.-Adenosine
.beta.-D-Adenosine
.beta.-D-Ribofuranose, 1-(6-amino-9H-purin-9-yl)-1-deoxy-
.beta.-D-Ribofuranoside, adenine-9
(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
[U-14C]adenosine
1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose
1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-delta-Ribofuranose
158749-77-0
177030-94-3
1dgm
1odi
244769-76-4
2fqy
2gl0
2ydo
30143-02-3
3axz
3ay0
3H-adenosine
4-Aminopyrazolo[3,4-d]pyrimidine ribonucleoside
46946-45-6
46969-16-8
4cki
4ckj
4pd9
5536-17-4
58-61-7
6-Amino-9-.beta.-ribofuranosyl-9H-purine
6-Amino-9-beta-D-ribofuranosyl-9H-purine
6-Amino-9.beta.-D-ribofuranosyl-9H-purine
6-Amino-9beta-D-ribofuranosyl-9H-purine
6-Amino-9beta-delta-ribofuranosyl-9H-purine
9- -D-Ribofuranosyladenine
9-?-D-Ribofuranosyl-9H-purin-6-amine
9-.alpha.-D-Arabinofuranosyladenine
9-.beta.-D-Ribofuranosidoadenine
9-.beta.-D-Ribofuranosyl-9H-purin-6-amine
9-.beta.-d-Ribofuranosyladenine
9-(beta-D-Arabinofuranosyl)adenine
9-beta-D-Ribofuranosidoadenine
9-beta-D-Ribofuranosyl-9H-purin-6-amine
9-beta-D-Ribofuranosyladenine
9-beta-delta-Arabinofuranosyladenine
9-beta-delta-Ribofuranosidoadenine
9-beta-delta-Ribofuranosyl-9H-purin-6-amine
9-beta-delta-Ribofuranosyladenine
9beta-D-ribofuranosyl-9H-Purin-6-amine
9beta-D-Ribofuranosyladenine
9beta-delta-ribofuranosyl-9H-Purin-6-amine
9beta-delta-Ribofuranosyladenine
9H-Purin-6-amine, 9-.beta.-d-ribofuranosyl-
9H-Purin-6-amine, 9beta-D-ribofuranosyl-
A0152
AB0012292
AB00384349_13
AB00384349_14
AB00384349-11
AC-27494
AC-8229
AC1L1U8O
AC1Q1ID3
AC1Q52XU
ACT02616
Ade-Rib
Adenin riboside
Adenine 9-beta-D-arabinofuranoside
Adenine nucleoside
Adenine riboside
Adenine riboside, Adenine-9-beta-D-ribofuranoside
Adenine-9- -D-ribofuranoside
Adenine-9-beta-D-ribofuranoside
adenine-9beta-D-Ribofuranoside
adenine-9beta-delta-Ribofuranoside
adenine-D-ribose
Adenocard
Adenocard (TN)
Adenocard, Adenosine
Adenocor
Adenoscan
Adenoscan (TN)
Adenosin
Adenosin [German]
Adenosina
Adenosine (Adenocard)
Adenosine (JAN/USP)
Adenosine [USAN:BAN]
Adenosine [USAN:USP:BAN]
adenosine-2-13C-N,1,3-15N3
adenosine-8-13C
adenosine-9-15N
adenosine-N-15N
Adenosine, >=99%
Adenosine, European Pharmacopoeia (EP) Reference Standard
Adenosine, homopolymer
Adenosine, pharmaceutical secondary standard; traceable to USP and PhEur
Adenosine, suitable for cell culture, BioReagent
Adenosine, United States Pharmacopeia (USP) Reference Standard
Adenosine, Vetec(TM) reagent grade, 98%
Adenosinum
Adensoine
AI3-52413
AJ-34020
AK-77288
AKOS015888594
alpha-Adenosine
AM83931
ANW-32994
Arabinosyl-adenine
AS-12664
AT-11502
b-D-Adenosine
BB_NC-0565
BDBM14487
beta-Adenosine
beta-D-Adenosine
beta-D-Ribofuranose, 1-(6-amino-9H-purin-9-yl)-1-deoxy-
beta-D-Ribofuranoside, adenine-9
beta-delta-Adenosine
Bio1_000437
Bio1_000926
Bio1_001415
bmse000061
bmse000996
Boniton
BR-77288
BSPBio_001796
BT000369
C00212
CAS-58-61-7
Caswell No. 010B
CCG-38824
CCRIS 2557
CHEBI:16335
CHEMBL477
cid_191
cid_60961
CJ-07924
CTK1G9587
D-Adenosine
D00045
D06IAR
DB-022408
DB00640
DSSTox_CID_2558
DSSTox_GSID_22558
DSSTox_RID_76628
DTXSID1022558
EA6C60C2-6AFB-4264-A2F0-541373DB950E
EINECS 200-389-9
Epitope ID:140947
Formycin A, from Streptomyces kaniharaensis, >=98% (HPLC)
FT-0082881
FT-0620931
GTPL2844
HMS1920A13
HMS2091G13
HMS2235E24
HSDB 7774
K72T3FS567
KB-47159
KBio3_001296
KS-0000010G
KSC269K8P
LS-15085
MCULE-7071766082
MEDR-640
MFCD00005752
MFCD00065471
MLS000069638
MLS002153227
MLS006010946
MolPort-001-838-229
Myocol
N6-Methylado
NCGC00023673-03
NCGC00023673-04
NCGC00023673-05
NCGC00023673-06
NCGC00023673-07
NCGC00178869-03
NSC 627048
NSC 7652
NSC-755857
NSC627048
NSC755857
NSC7652
NU001462
NU007624
NU007625
NU008403
Nucleocardyl
OIRDTQYFTABQOQ-KQYNXXCUSA-N
Pallacor
Pharmakon1600-01500107
Polyadenosine
Polyriboadenosine
PubChem9306
REGID_for_CID_60961
Riboadenosine
RP29522
RP29523
RTR-020367
S-3476
s1647
Sandesin
SBI-0206673.P002
SCHEMBL731
SDCCGMLS-0003108.P003
SMR000058216
SPBio_001194
SPECTRUM1500107
Spectrum2_001257
Spectrum3_000288
SR 96225
SR-05000001981
SR-05000001981-2
SR-96225
ST009496
ST2407911
SUN-Y4001
TL8003749
Tox21_110891
Tox21_110891_1
TR-020367
UNII-K72T3FS567
USAF CB-10
Z1741978458
ZINC2169830

Tentative approvals for ADENOSINE

Applicant	Application No.	Strength	Dosage Form
➤ Sign Up	➤ Sign Up	3MG/ML	INJECTABLE; INJECTION
➤ Sign Up	➤ Sign Up	3MG/ML	INJECTABLE; INJECTION
➤ Sign Up	➤ Sign Up	3MG/ML	INJECTABLE; INJECTION

US Patents and Regulatory Information for adenosine

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Glossary

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Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
West-ward Pharms Int	ADENOSINE	adenosine	INJECTABLE;INJECTION	076404-001	Jun 16, 2004	AP	RX	No	No	➤ Sign Up	➤ Sign Up				➤ Sign Up
Astellas	ADENOSCAN	adenosine	SOLUTION;IV (INFUSION)	020059-001	May 18, 1995		DISCN	Yes	No	➤ Sign Up	➤ Sign Up				➤ Sign Up
Gland Pharma Ltd	ADENOSINE	adenosine	INJECTABLE;INJECTION	206778-001	Feb 16, 2018	AP	RX	No	No	➤ Sign Up	➤ Sign Up				➤ Sign Up
Emcure Pharms Ltd	ADENOSINE	adenosine	SOLUTION;IV (INFUSION)	202313-001	Sep 15, 2014	AP	RX	No	No	➤ Sign Up	➤ Sign Up				➤ Sign Up
Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration

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Expired US Patents for adenosine

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Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	Patent No.	Patent Expiration
Astellas	ADENOSCAN	adenosine	SOLUTION;IV (INFUSION)	020059-001	May 18, 1995	➤ Sign Up	➤ Sign Up
Astellas	ADENOCARD	adenosine	INJECTABLE;INJECTION	019937-002	Oct 30, 1989	➤ Sign Up	➤ Sign Up
Astellas	ADENOSCAN	adenosine	SOLUTION;IV (INFUSION)	020059-002	May 18, 1995	➤ Sign Up	➤ Sign Up
Astellas	ADENOSCAN	adenosine	SOLUTION;IV (INFUSION)	020059-001	May 18, 1995	➤ Sign Up	➤ Sign Up
Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	Patent No.	Patent Expiration