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Adenosine - Generic Drug Details

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What are the generic drug sources for adenosine and what is the scope of adenosine patent protection?

Adenosine is the generic ingredient in three branded drugs marketed by Astellas, Akorn, Fresenius Kabi Usa, Gland Pharma Ltd, Luitpold, Mylan Labs Ltd, Teva Pharms Usa, West-ward Pharms Int, Wockhardt, Aurobindo Pharma Ltd, Emcure Pharms Ltd, Hospira Inc, and Mylan Asi, and is included in twenty-three NDAs. Additional information is available in the individual branded drug profile pages.

There are twenty-six drug master file entries for adenosine. Nineteen suppliers are listed for this compound. There are three tentative approvals for this compound.

Summary for adenosine

US Patents:	0
Tradenames:	3
Applicants:	13
NDAs:	23
Drug Master File Entries:	26
Suppliers / Packagers:	19
Bulk Api Vendors:	106
Clinical Trials:	383
Patent Applications:	7,244
Formulation / Manufacturing:	see details
Drug Prices:	Drug price information for adenosine
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for adenosine
DailyMed Link:	adenosine at DailyMed

Pharmacology for adenosine

Drug Class	Adenosine Receptor Agonist
Mechanism of Action	Adenosine Receptor Agonists

Medical Subject Heading (MeSH) Categories for adenosine

Analgesics

Anti-Arrhythmia Agents

Purinergic P1 Receptor Agonists

Vasodilator Agents

Synonyms for adenosine

.beta.-Adenosine

.beta.-D-Adenosine

.beta.-D-Ribofuranose, 1-(6-amino-9H-purin-9-yl)-1-deoxy-

.beta.-D-Ribofuranoside, adenine-9

(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

[U-14C]adenosine

1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose

1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-delta-Ribofuranose

158749-77-0

177030-94-3

1dgm

1odi

244769-76-4

2fqy

2gl0

2ydo

30143-02-3

3axz

3ay0

3H-adenosine

4-Aminopyrazolo[3,4-d]pyrimidine ribonucleoside

46946-45-6

46969-16-8

4cki

4ckj

4pd9

5536-17-4

58-61-7

6-Amino-9-.beta.-ribofuranosyl-9H-purine

6-Amino-9-beta-D-ribofuranosyl-9H-purine

6-Amino-9.beta.-D-ribofuranosyl-9H-purine

6-Amino-9beta-D-ribofuranosyl-9H-purine

6-Amino-9beta-delta-ribofuranosyl-9H-purine

9- -D-Ribofuranosyladenine

9-?-D-Ribofuranosyl-9H-purin-6-amine

9-.alpha.-D-Arabinofuranosyladenine

9-.beta.-D-Ribofuranosidoadenine

9-.beta.-D-Ribofuranosyl-9H-purin-6-amine

9-.beta.-d-Ribofuranosyladenine

9-(beta-D-Arabinofuranosyl)adenine

9-beta-D-Ribofuranosidoadenine

9-beta-D-Ribofuranosyl-9H-purin-6-amine

9-beta-D-Ribofuranosyladenine

9-beta-delta-Arabinofuranosyladenine

9-beta-delta-Ribofuranosidoadenine

9-beta-delta-Ribofuranosyl-9H-purin-6-amine

9-beta-delta-Ribofuranosyladenine

9beta-D-ribofuranosyl-9H-Purin-6-amine

9beta-D-Ribofuranosyladenine

9beta-delta-ribofuranosyl-9H-Purin-6-amine

9beta-delta-Ribofuranosyladenine

9H-Purin-6-amine, 9-.beta.-d-ribofuranosyl-

9H-Purin-6-amine, 9beta-D-ribofuranosyl-

A0152

AB0012292

AB00384349_13

AB00384349_14

AB00384349-11

AC-27494

AC-8229

AC1L1U8O

AC1Q1ID3

AC1Q52XU

ACT02616

Ade-Rib

Adenin riboside

Adenine 9-beta-D-arabinofuranoside

Adenine nucleoside

Adenine riboside

Adenine riboside, Adenine-9-beta-D-ribofuranoside

Adenine-9- -D-ribofuranoside

Adenine-9-beta-D-ribofuranoside

adenine-9beta-D-Ribofuranoside

adenine-9beta-delta-Ribofuranoside

adenine-D-ribose

Adenocard

Adenocard (TN)

Adenocard, Adenosine

Adenocor

Adenoscan

Adenoscan (TN)

Adenosin

Adenosin [German]

Adenosina

Adenosine (Adenocard)

Adenosine (JAN/USP)

Adenosine [USAN:BAN]

Adenosine [USAN:USP:BAN]

adenosine-2-13C-N,1,3-15N3

adenosine-8-13C

adenosine-9-15N

adenosine-N-15N

Adenosine, >=99%

Adenosine, European Pharmacopoeia (EP) Reference Standard

Adenosine, homopolymer

Adenosine, pharmaceutical secondary standard; traceable to USP and PhEur

Adenosine, suitable for cell culture, BioReagent

Adenosine, United States Pharmacopeia (USP) Reference Standard

Adenosine, Vetec(TM) reagent grade, 98%

Adenosinum

Adensoine

AI3-52413

AJ-34020

AK-77288

AKOS015888594

alpha-Adenosine

AM83931

ANW-32994

Arabinosyl-adenine

AS-12664

AT-11502

b-D-Adenosine

BB_NC-0565

BDBM14487

beta-Adenosine

beta-D-Adenosine

beta-D-Ribofuranose, 1-(6-amino-9H-purin-9-yl)-1-deoxy-

beta-D-Ribofuranoside, adenine-9

beta-delta-Adenosine

Bio1_000437

Bio1_000926

Bio1_001415

bmse000061

bmse000996

Boniton

BR-77288

BSPBio_001796

BT000369

C00212

CAS-58-61-7

Caswell No. 010B

CCG-38824

CCRIS 2557

CHEBI:16335

CHEMBL477

cid_191

cid_60961

CJ-07924

CTK1G9587

D-Adenosine

D00045

D06IAR

DB-022408

DB00640

DSSTox_CID_2558

DSSTox_GSID_22558

DSSTox_RID_76628

DTXSID1022558

EA6C60C2-6AFB-4264-A2F0-541373DB950E

EINECS 200-389-9

Epitope ID:140947

Formycin A, from Streptomyces kaniharaensis, >=98% (HPLC)

FT-0082881

FT-0620931

GTPL2844

HMS1920A13

HMS2091G13

HMS2235E24

HSDB 7774

K72T3FS567

KB-47159

KBio3_001296

KS-0000010G

KSC269K8P

LS-15085

MCULE-7071766082

MEDR-640

MFCD00005752

MFCD00065471

MLS000069638

MLS002153227

MLS006010946

MolPort-001-838-229

Myocol

N6-Methylado

NCGC00023673-03

NCGC00023673-04

NCGC00023673-05

NCGC00023673-06

NCGC00023673-07

NCGC00178869-03

NSC 627048

NSC 7652

NSC-755857

NSC627048

NSC755857

NSC7652

NU001462

NU007624

NU007625

NU008403

Nucleocardyl

OIRDTQYFTABQOQ-KQYNXXCUSA-N

Pallacor

Pharmakon1600-01500107

Polyadenosine

Polyriboadenosine

PubChem9306

REGID_for_CID_60961

Riboadenosine

RP29522

RP29523

RTR-020367

S-3476

s1647

Sandesin

SBI-0206673.P002

SCHEMBL731

SDCCGMLS-0003108.P003

SMR000058216

SPBio_001194

SPECTRUM1500107

Spectrum2_001257

Spectrum3_000288

SR 96225

SR-05000001981

SR-05000001981-2

SR-96225

ST009496

ST2407911

SUN-Y4001

TL8003749

Tox21_110891

Tox21_110891_1

TR-020367

UNII-K72T3FS567

USAF CB-10

Z1741978458

ZINC2169830

Tentative approvals for ADENOSINE

Applicant	Application No.	Strength	Dosage Form
		3MG/ML	INJECTABLE; INJECTION
		3MG/ML	INJECTABLE; INJECTION
		3MG/ML	INJECTABLE; INJECTION

US Patents and Regulatory Information for adenosine

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
Mylan Asi	ADENOSINE	adenosine	SOLUTION;INTRAVENOUS	090212-001	Mar 28, 2014	AP	RX	No	No
Emcure Pharms Ltd	ADENOSINE	adenosine	SOLUTION;INTRAVENOUS	202313-001	Sep 15, 2014	AP	RX	No	No
Teva Pharms Usa	ADENOSINE	adenosine	INJECTABLE;INJECTION	078676-001	Jul 31, 2008		DISCN	No	No
West-ward Pharms Int	ADENOSINE	adenosine	INJECTABLE;INJECTION	076500-001	Jun 16, 2004	AP	RX	No	No
Aurobindo Pharma Ltd	ADENOSINE	adenosine	SOLUTION;INTRAVENOUS	205331-002	Nov 2, 2017	AP	RX	No	No
Emcure Pharms Ltd	ADENOSINE	adenosine	SOLUTION;INTRAVENOUS	202313-002	Sep 15, 2014	AP	RX	No	No

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Expired US Patents for adenosine

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	Patent No.	Patent Expiration
Astellas	ADENOCARD	adenosine	INJECTABLE;INJECTION	019937-002	Oct 30, 1989
Astellas	ADENOSCAN	adenosine	SOLUTION;INTRAVENOUS	020059-001	May 18, 1995
Astellas	ADENOSCAN	adenosine	SOLUTION;INTRAVENOUS	020059-001	May 18, 1995
Astellas	ADENOSCAN	adenosine	SOLUTION;INTRAVENOUS	020059-002	May 18, 1995

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