Last Updated: May 11, 2026

Expiring Drug Patents Cheat Sheet
We analyse the patents covering drugs in 134 countries and quickly give you the likely loss-of-exclusivity/generic entry date

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Israel: These 30 Drugs Face Patent Expirations and Generic Entry From 2026 - 2027

The content of this page is licensed under a Creative Commons Attribution 4.0 International License. Creative Commons License

Preferred citation:
Friedman, Yali, "Israel: These 30 Drugs Face Patent Expirations and Generic Entry From 2026 - 2027" DrugPatentWatch.com thinkBiotech, 2026 www.drugpatentwatch.com/p/expiring-drug-patents-generic-entry/.
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These estimated drug patent expiration dates and generic entry opportunity dates are calculated from analysis of known patents covering drugs. Many factors can influence early or late generic entry. This information is provided as a rough estimate of generic entry potential and should not be used as an independent source. The methodology is described in this blog post.
When can FARYDAK (panobinostat lactate) generic drug versions launch?

Generic name: panobinostat lactate
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 12, 2026
Generic Entry Controlled by: Israel Patent 195,015

FARYDAK is a drug marketed by Secura. There are two patents protecting this drug.

This drug has sixty-eight patent family members in forty countries. There has been litigation on patents covering FARYDAK

See drug price trends for FARYDAK.

The generic ingredient in FARYDAK is panobinostat lactate. There is one drug master file entry for this API. Additional details are available on the panobinostat lactate profile page.

When can TRINTELLIX (vortioxetine hydrobromide) generic drug versions launch?

Generic name: vortioxetine hydrobromide
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 16, 2026
Generic Entry Controlled by: Israel Patent 200,956
Patent Title: 1-[2-(2,4-דימתילפנילסולפניל)-פניל]פיפרזין לטיפול בכאב (1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine for use in the treatment of pain)

Drug Price Trends for TRINTELLIX
TRINTELLIX is a drug marketed by Takeda Pharms Usa. There are ten patents protecting this drug and one Paragraph IV challenge. Three tentatively approved generics are ready to enter the market.

This drug has two hundred and seventeen patent family members in forty-two countries. There has been litigation on patents covering TRINTELLIX

See drug price trends for TRINTELLIX.

The generic ingredient in TRINTELLIX is vortioxetine hydrobromide. There are sixteen drug master file entries for this API. Three suppliers are listed for this generic product. Additional details are available on the vortioxetine hydrobromide profile page.

When can EMBEDA (morphine sulfate; naltrexone hydrochloride) generic drug versions launch?

Generic name: morphine sulfate; naltrexone hydrochloride
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 19, 2026
Generic Entry Controlled by: Israel Patent 195,834

EMBEDA is a drug marketed by Alpharma Pharms. There are seven patents protecting this drug and four Paragraph IV challenges.

This drug has seventy-four patent family members in twenty-three countries.

See drug price trends for EMBEDA.

The generic ingredient in EMBEDA is morphine sulfate; naltrexone hydrochloride. There are twenty-three drug master file entries for this API. Additional details are available on the morphine sulfate; naltrexone hydrochloride profile page.

When can EMBEDA (morphine sulfate; naltrexone hydrochloride) generic drug versions launch?

Generic name: morphine sulfate; naltrexone hydrochloride
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 19, 2026
Generic Entry Controlled by: Israel Patent 235,150

EMBEDA is a drug marketed by Alpharma Pharms. There are seven patents protecting this drug and four Paragraph IV challenges.

This drug has seventy-four patent family members in twenty-three countries.

See drug price trends for EMBEDA.

The generic ingredient in EMBEDA is morphine sulfate; naltrexone hydrochloride. There are twenty-three drug master file entries for this API. Additional details are available on the morphine sulfate; naltrexone hydrochloride profile page.

When can XADAGO (safinamide mesylate) generic drug versions launch?

Generic name: safinamide mesylate
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 19, 2026
Generic Entry Controlled by: Israel Patent 195,294

Drug Price Trends for XADAGO
XADAGO is a drug marketed by Mdd Us. There are three patents protecting this drug.

This drug has ninety-seven patent family members in thirty-one countries. There has been litigation on patents covering XADAGO

See drug price trends for XADAGO.

The generic ingredient in XADAGO is safinamide mesylate. There are two drug master file entries for this API. One supplier is listed for this generic product. Additional details are available on the safinamide mesylate profile page.

When can JESDUVROQ (daprodustat) generic drug versions launch?

Generic name: daprodustat
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 23, 2026
Generic Entry Controlled by: Israel Patent 196,070

JESDUVROQ is a drug marketed by Glaxosmithkline. There are six patents protecting this drug.

This drug has forty-four patent family members in thirty-one countries.

See drug price trends for JESDUVROQ.

The generic ingredient in JESDUVROQ is daprodustat. One supplier is listed for this generic product. Additional details are available on the daprodustat profile page.

When can TEKTURNA HCT (aliskiren hemifumarate; hydrochlorothiazide) generic drug versions launch?

Generic name: aliskiren hemifumarate; hydrochlorothiazide
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 23, 2026
Generic Entry Controlled by: Israel Patent 195,425
Patent Title: תכשירים גלניקלים של אליסקירן והידרוכלורותיאזיד (Galenical formulations of aliskiren and hydrochlorothiazide)

Drug Price Trends for TEKTURNA HCT
TEKTURNA HCT is a drug marketed by Noden Pharma. There is one patent protecting this drug and one Paragraph IV challenge.

This drug has thirty-two patent family members in twenty-five countries. There has been litigation on patents covering TEKTURNA HCT

See drug price trends for TEKTURNA HCT.

The generic ingredient in TEKTURNA HCT is aliskiren hemifumarate; hydrochlorothiazide. There are four drug master file entries for this API. Additional details are available on the aliskiren hemifumarate; hydrochlorothiazide profile page.

When can BYDUREON (exenatide synthetic) generic drug versions launch?

Generic name: exenatide synthetic
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 28, 2026
Generic Entry Controlled by: Israel Patent 195,882

Drug Price Trends for BYDUREON
BYDUREON is a drug marketed by Astrazeneca Ab. There are seven patents protecting this drug.

This drug has three hundred and seven patent family members in forty-eight countries. There has been litigation on patents covering BYDUREON

See drug price trends for BYDUREON.

The generic ingredient in BYDUREON is exenatide synthetic. There are seven drug master file entries for this API. Two suppliers are listed for this generic product. Additional details are available on the exenatide synthetic profile page.

When can BYDUREON (exenatide synthetic) generic drug versions launch?

Generic name: exenatide synthetic
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 28, 2026
Generic Entry Controlled by: Israel Patent 214,180

Drug Price Trends for BYDUREON
BYDUREON is a drug marketed by Astrazeneca Ab. There are seven patents protecting this drug.

This drug has three hundred and seven patent family members in forty-eight countries. There has been litigation on patents covering BYDUREON

See drug price trends for BYDUREON.

The generic ingredient in BYDUREON is exenatide synthetic. There are seven drug master file entries for this API. Two suppliers are listed for this generic product. Additional details are available on the exenatide synthetic profile page.

When can BYDUREON (exenatide synthetic) generic drug versions launch?

Generic name: exenatide synthetic
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 28, 2026
Generic Entry Controlled by: Israel Patent 214,181

Drug Price Trends for BYDUREON
BYDUREON is a drug marketed by Astrazeneca Ab. There are seven patents protecting this drug.

This drug has three hundred and seven patent family members in forty-eight countries. There has been litigation on patents covering BYDUREON

See drug price trends for BYDUREON.

The generic ingredient in BYDUREON is exenatide synthetic. There are seven drug master file entries for this API. Two suppliers are listed for this generic product. Additional details are available on the exenatide synthetic profile page.

When can BYDUREON (exenatide synthetic) generic drug versions launch?

Generic name: exenatide synthetic
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 28, 2026
Generic Entry Controlled by: Israel Patent 214,182

Drug Price Trends for BYDUREON
BYDUREON is a drug marketed by Astrazeneca Ab. There are seven patents protecting this drug.

This drug has three hundred and seven patent family members in forty-eight countries. There has been litigation on patents covering BYDUREON

See drug price trends for BYDUREON.

The generic ingredient in BYDUREON is exenatide synthetic. There are seven drug master file entries for this API. Two suppliers are listed for this generic product. Additional details are available on the exenatide synthetic profile page.

When can FARXIGA (dapagliflozin) generic drug versions launch?

Generic name: dapagliflozin
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 28, 2026
Generic Entry Controlled by: Israel Patent 195,882

Drug Price Trends for FARXIGA
FARXIGA is a drug marketed by Astrazeneca Ab. There are seventeen patents protecting this drug and one Paragraph IV challenge. Thirteen tentatively approved generics are ready to enter the market.

This drug has four hundred and twenty-five patent family members in fifty-two countries. There has been litigation on patents covering FARXIGA

See drug price trends for FARXIGA.

The generic ingredient in FARXIGA is dapagliflozin. There are twenty-six drug master file entries for this API. Twenty-two suppliers are listed for this generic product. Additional details are available on the dapagliflozin profile page.

When can FARXIGA (dapagliflozin) generic drug versions launch?

Generic name: dapagliflozin
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 28, 2026
Generic Entry Controlled by: Israel Patent 214,180

Drug Price Trends for FARXIGA
FARXIGA is a drug marketed by Astrazeneca Ab. There are seventeen patents protecting this drug and one Paragraph IV challenge. Thirteen tentatively approved generics are ready to enter the market.

This drug has four hundred and twenty-five patent family members in fifty-two countries. There has been litigation on patents covering FARXIGA

See drug price trends for FARXIGA.

The generic ingredient in FARXIGA is dapagliflozin. There are twenty-six drug master file entries for this API. Twenty-two suppliers are listed for this generic product. Additional details are available on the dapagliflozin profile page.

When can FARXIGA (dapagliflozin) generic drug versions launch?

Generic name: dapagliflozin
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 28, 2026
Generic Entry Controlled by: Israel Patent 214,181

Drug Price Trends for FARXIGA
FARXIGA is a drug marketed by Astrazeneca Ab. There are seventeen patents protecting this drug and one Paragraph IV challenge. Thirteen tentatively approved generics are ready to enter the market.

This drug has four hundred and twenty-five patent family members in fifty-two countries. There has been litigation on patents covering FARXIGA

See drug price trends for FARXIGA.

The generic ingredient in FARXIGA is dapagliflozin. There are twenty-six drug master file entries for this API. Twenty-two suppliers are listed for this generic product. Additional details are available on the dapagliflozin profile page.

When can FARXIGA (dapagliflozin) generic drug versions launch?

Generic name: dapagliflozin
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 28, 2026
Generic Entry Controlled by: Israel Patent 214,182

Drug Price Trends for FARXIGA
FARXIGA is a drug marketed by Astrazeneca Ab. There are seventeen patents protecting this drug and one Paragraph IV challenge. Thirteen tentatively approved generics are ready to enter the market.

This drug has four hundred and twenty-five patent family members in fifty-two countries. There has been litigation on patents covering FARXIGA

See drug price trends for FARXIGA.

The generic ingredient in FARXIGA is dapagliflozin. There are twenty-six drug master file entries for this API. Twenty-two suppliers are listed for this generic product. Additional details are available on the dapagliflozin profile page.

When can QTERN (dapagliflozin; saxagliptin hydrochloride) generic drug versions launch?

Generic name: dapagliflozin; saxagliptin hydrochloride
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 28, 2026
Generic Entry Controlled by: Israel Patent 195,882

Drug Price Trends for QTERN
QTERN is a drug marketed by Astrazeneca Ab. There are seven patents protecting this drug and one Paragraph IV challenge.

This drug has two hundred and fifty-six patent family members in forty-eight countries. There has been litigation on patents covering QTERN

See drug price trends for QTERN.

The generic ingredient in QTERN is dapagliflozin; saxagliptin hydrochloride. There are twenty-six drug master file entries for this API. One supplier is listed for this generic product. Additional details are available on the dapagliflozin; saxagliptin hydrochloride profile page.

When can QTERN (dapagliflozin; saxagliptin hydrochloride) generic drug versions launch?

Generic name: dapagliflozin; saxagliptin hydrochloride
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 28, 2026
Generic Entry Controlled by: Israel Patent 214,180

Drug Price Trends for QTERN
QTERN is a drug marketed by Astrazeneca Ab. There are seven patents protecting this drug and one Paragraph IV challenge.

This drug has two hundred and fifty-six patent family members in forty-eight countries. There has been litigation on patents covering QTERN

See drug price trends for QTERN.

The generic ingredient in QTERN is dapagliflozin; saxagliptin hydrochloride. There are twenty-six drug master file entries for this API. One supplier is listed for this generic product. Additional details are available on the dapagliflozin; saxagliptin hydrochloride profile page.

When can QTERN (dapagliflozin; saxagliptin hydrochloride) generic drug versions launch?

Generic name: dapagliflozin; saxagliptin hydrochloride
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 28, 2026
Generic Entry Controlled by: Israel Patent 214,181

Drug Price Trends for QTERN
QTERN is a drug marketed by Astrazeneca Ab. There are seven patents protecting this drug and one Paragraph IV challenge.

This drug has two hundred and fifty-six patent family members in forty-eight countries. There has been litigation on patents covering QTERN

See drug price trends for QTERN.

The generic ingredient in QTERN is dapagliflozin; saxagliptin hydrochloride. There are twenty-six drug master file entries for this API. One supplier is listed for this generic product. Additional details are available on the dapagliflozin; saxagliptin hydrochloride profile page.

When can QTERN (dapagliflozin; saxagliptin hydrochloride) generic drug versions launch?

Generic name: dapagliflozin; saxagliptin hydrochloride
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 28, 2026
Generic Entry Controlled by: Israel Patent 214,182

Drug Price Trends for QTERN
QTERN is a drug marketed by Astrazeneca Ab. There are seven patents protecting this drug and one Paragraph IV challenge.

This drug has two hundred and fifty-six patent family members in forty-eight countries. There has been litigation on patents covering QTERN

See drug price trends for QTERN.

The generic ingredient in QTERN is dapagliflozin; saxagliptin hydrochloride. There are twenty-six drug master file entries for this API. One supplier is listed for this generic product. Additional details are available on the dapagliflozin; saxagliptin hydrochloride profile page.

When can EVOTAZ (atazanavir sulfate; cobicistat) generic drug versions launch?

Generic name: atazanavir sulfate; cobicistat
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: July 07, 2026
Generic Entry Controlled by: Israel Patent 195,488
Patent Title: תרכובות, תכשירים רוקחיים המכילים אותן ושימושים שלהם (Compounds, pharmaceutical compositions comprising the same and uses thereof)

Drug Price Trends for EVOTAZ
EVOTAZ is a drug marketed by Bristol. There are two patents protecting this drug and one Paragraph IV challenge.

This drug has three hundred and six patent family members in forty-one countries. There has been litigation on patents covering EVOTAZ

See drug price trends for EVOTAZ.

The generic ingredient in EVOTAZ is atazanavir sulfate; cobicistat. There are twenty-five drug master file entries for this API. One supplier is listed for this generic product. Additional details are available on the atazanavir sulfate; cobicistat profile page.

When can DAKLINZA (daclatasvir dihydrochloride) generic drug versions launch?

Generic name: daclatasvir dihydrochloride
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: August 11, 2026
Generic Entry Controlled by: Israel Patent 196,813

Drug Price Trends for DAKLINZA
DAKLINZA is a drug marketed by Bristol-myers Squibb. There are five patents protecting this drug.

This drug has ninety-three patent family members in thirty-one countries. There has been litigation on patents covering DAKLINZA

See drug price trends for DAKLINZA.

The generic ingredient in DAKLINZA is daclatasvir dihydrochloride. There are five drug master file entries for this API. Additional details are available on the daclatasvir dihydrochloride profile page.

When can BRILINTA (ticagrelor) generic drug versions launch?

Generic name: ticagrelor
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: August 21, 2026
Generic Entry Controlled by: Israel Patent 196,700

Drug Price Trends for BRILINTA
BRILINTA is a drug marketed by Astrazeneca. There are two patents protecting this drug and two Paragraph IV challenges. One tentatively approved generic is ready to enter the market.

This drug has sixty-two patent family members in thirty-five countries. There has been litigation on patents covering BRILINTA

See drug price trends for BRILINTA.

The generic ingredient in BRILINTA is ticagrelor. There are twenty-one drug master file entries for this API. Twenty-six suppliers are listed for this generic product. Additional details are available on the ticagrelor profile page.

When can TYMLOS (abaloparatide) generic drug versions launch?

Generic name: abaloparatide
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: October 03, 2026
Generic Entry Controlled by: Israel Patent 197,926
Patent Title: תכשיר יציב המכיל חלבון עצם אנבולי, דהיינו אנלוג ל–pthrp, ושימושיו (Stable composition comprising a bone anabolic protein, namely a pthrp analogue, and uses thereof)

Drug Price Trends for TYMLOS
TYMLOS is a drug marketed by Radius. There are nine patents protecting this drug.

This drug has fifty-six patent family members in twenty-nine countries. There has been litigation on patents covering TYMLOS

See drug price trends for TYMLOS.

The generic ingredient in TYMLOS is abaloparatide. One supplier is listed for this generic product. Additional details are available on the abaloparatide profile page.

When can KORSUVA (difelikefalin acetate) generic drug versions launch?

Generic name: difelikefalin acetate
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: November 10, 2026
Generic Entry Controlled by: Israel Patent 197,923

KORSUVA is a drug marketed by Vifor Intl. There are twelve patents protecting this drug.

This drug has fifty-three patent family members in twenty-seven countries. There has been litigation on patents covering KORSUVA

See drug price trends for KORSUVA.

The generic ingredient in KORSUVA is difelikefalin acetate. One supplier is listed for this generic product. Additional details are available on the difelikefalin acetate profile page.

When can KORSUVA (difelikefalin acetate) generic drug versions launch?

Generic name: difelikefalin acetate
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: November 10, 2026
Generic Entry Controlled by: Israel Patent 197,924

KORSUVA is a drug marketed by Vifor Intl. There are twelve patents protecting this drug.

This drug has fifty-three patent family members in twenty-seven countries. There has been litigation on patents covering KORSUVA

See drug price trends for KORSUVA.

The generic ingredient in KORSUVA is difelikefalin acetate. One supplier is listed for this generic product. Additional details are available on the difelikefalin acetate profile page.

When can SIRTURO (bedaquiline fumarate) generic drug versions launch?

Generic name: bedaquiline fumarate
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: December 05, 2026
Generic Entry Controlled by: Israel Patent 199,077

SIRTURO is a drug marketed by Janssen Therap. There are two patents protecting this drug.

This drug has ninety-seven patent family members in thirty-nine countries.

See drug price trends for SIRTURO.

The generic ingredient in SIRTURO is bedaquiline fumarate. There is one drug master file entry for this API. One supplier is listed for this generic product. Additional details are available on the bedaquiline fumarate profile page.

When can ZYKADIA (ceritinib) generic drug versions launch?

Generic name: ceritinib
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: December 08, 2026
Generic Entry Controlled by: Israel Patent 230,972

ZYKADIA is a drug marketed by Novartis. There are eight patents protecting this drug.

This drug has three hundred and twenty-two patent family members in fifty-six countries.

See drug price trends for ZYKADIA.

The generic ingredient in ZYKADIA is ceritinib. There is one drug master file entry for this API. One supplier is listed for this generic product. Additional details are available on the ceritinib profile page.

When can XERMELO (telotristat etiprate) generic drug versions launch?

Generic name: telotristat etiprate
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: December 12, 2026
Generic Entry Controlled by: Israel Patent 198,806

XERMELO is a drug marketed by Tersera. There are five patents protecting this drug.

This drug has seventy patent family members in twenty-nine countries.

See drug price trends for XERMELO.

The generic ingredient in XERMELO is telotristat etiprate. One supplier is listed for this generic product. Additional details are available on the telotristat etiprate profile page.

When can XERMELO (telotristat etiprate) generic drug versions launch?

Generic name: telotristat etiprate
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: December 12, 2026
Generic Entry Controlled by: Israel Patent 235,288
Patent Title: צורת מינון המכילה תרכובות המבוססות על 4–פניל–6–(2,2,2–טריפלואורו–1–פנילאתוקסי)פירימידין (Dosage form containing 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds)

XERMELO is a drug marketed by Tersera. There are five patents protecting this drug.

This drug has seventy patent family members in twenty-nine countries.

See drug price trends for XERMELO.

The generic ingredient in XERMELO is telotristat etiprate. One supplier is listed for this generic product. Additional details are available on the telotristat etiprate profile page.

When can OSENI (alogliptin benzoate; pioglitazone hydrochloride) generic drug versions launch?

Generic name: alogliptin benzoate; pioglitazone hydrochloride
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: February 01, 2027
Generic Entry Controlled by: Israel Patent 200,108

Drug Price Trends for OSENI
OSENI is a drug marketed by Takeda Pharms Usa. There are two patents protecting this drug.

This drug has one hundred and one patent family members in forty-two countries. There has been litigation on patents covering OSENI

See drug price trends for OSENI.

The generic ingredient in OSENI is alogliptin benzoate; pioglitazone hydrochloride. There are ten drug master file entries for this API. Two suppliers are listed for this generic product. Additional details are available on the alogliptin benzoate; pioglitazone hydrochloride profile page.

When can PANCREAZE (pancrelipase (amylase;lipase;protease)) generic drug versions launch?

Generic name: pancrelipase (amylase;lipase;protease)
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: February 20, 2027
Generic Entry Controlled by: Israel Patent 200,407

PANCREAZE is a drug marketed by

This drug has one hundred and one patent family members in forty-two countries.

See drug price trends for PANCREAZE.

The generic ingredient in PANCREAZE is pancrelipase (amylase;lipase;protease). There are six drug master file entries for this API. Two suppliers are listed for this generic product. Additional details are available on the pancrelipase (amylase;lipase;protease) profile page.

When can ZENPEP (pancrelipase (amylase;lipase;protease)) generic drug versions launch?

Generic name: pancrelipase (amylase;lipase;protease)
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: February 20, 2027
Generic Entry Controlled by: Israel Patent 200,407

ZENPEP is a drug marketed by

This drug has one hundred and one patent family members in forty-two countries.

See drug price trends for ZENPEP.

The generic ingredient in ZENPEP is pancrelipase (amylase;lipase;protease). There are six drug master file entries for this API. Two suppliers are listed for this generic product. Additional details are available on the pancrelipase (amylase;lipase;protease) profile page.

When can XENLETA (lefamulin acetate) generic drug versions launch?

Generic name: lefamulin acetate
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: March 20, 2027
Generic Entry Controlled by: Israel Patent 200,440

XENLETA is a drug marketed by Hong Kong. There are four patents protecting this drug.

This drug has one hundred and twenty patent family members in thirty-six countries. There has been litigation on patents covering XENLETA

See drug price trends for XENLETA.

The generic ingredient in XENLETA is lefamulin acetate. Additional details are available on the lefamulin acetate profile page.

When can QVAR REDIHALER (beclomethasone dipropionate) generic drug versions launch?

Generic name: beclomethasone dipropionate
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: April 11, 2027
Generic Entry Controlled by: Israel Patent 201,256

Drug Price Trends for QVAR REDIHALER
QVAR REDIHALER is a drug marketed by Norton Waterford. There are seventeen patents protecting this drug. One tentatively approved generic is ready to enter the market.

This drug has two hundred and seventy-eight patent family members in twenty-seven countries. There has been litigation on patents covering QVAR REDIHALER

See drug price trends for QVAR REDIHALER.

The generic ingredient in QVAR REDIHALER is beclomethasone dipropionate. There are twenty drug master file entries for this API. Three suppliers are listed for this generic product. Additional details are available on the beclomethasone dipropionate profile page.

When can PROMACTA (eltrombopag olamine) generic drug versions launch?

Generic name: eltrombopag olamine
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: May 03, 2027
Generic Entry Controlled by: Israel Patent 201,891

PROMACTA is a drug marketed by Novartis. There are six patents protecting this drug and two Paragraph IV challenges.

This drug has one hundred and thirty-five patent family members in forty-one countries. There has been litigation on patents covering PROMACTA

See drug price trends for PROMACTA.

The generic ingredient in PROMACTA is eltrombopag olamine. There are three drug master file entries for this API. Eleven suppliers are listed for this generic product. Additional details are available on the eltrombopag olamine profile page.

When can SIGNIFOR LAR (pasireotide pamoate) generic drug versions launch?

Generic name: pasireotide pamoate
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: May 24, 2027
Generic Entry Controlled by: Israel Patent 201,571

SIGNIFOR LAR is a drug marketed by Recordati Rare. There are three patents protecting this drug.

This drug has one hundred and thirty-five patent family members in forty-one countries.

See drug price trends for SIGNIFOR LAR.

The generic ingredient in SIGNIFOR LAR is pasireotide pamoate. One supplier is listed for this generic product. Additional details are available on the pasireotide pamoate profile page.

When can TRELSTAR (triptorelin pamoate) generic drug versions launch?

Generic name: triptorelin pamoate
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 06, 2027
Generic Entry Controlled by: Israel Patent 202,501
Patent Title: תכשירים המכילים מיקרו חלקיקים לשחרור מבוקר של טריפטולרין ושימוש בהם להכנת תרופה לטיפול בסרטן הערמונית (Pharmaceutical composition made of microparticles for controlled release of triptorelin and use thereof for the manufacture of a drug for the treatment of prostate cancer)

TRELSTAR is a drug marketed by Verity. There is one patent protecting this drug.

This drug has forty-seven patent family members in thirty-two countries.

See drug price trends for TRELSTAR.

The generic ingredient in TRELSTAR is triptorelin pamoate. There are three drug master file entries for this API. Two suppliers are listed for this generic product. Additional details are available on the triptorelin pamoate profile page.

When can TRIPTODUR KIT (triptorelin pamoate) generic drug versions launch?

Generic name: triptorelin pamoate
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 06, 2027
Generic Entry Controlled by: Israel Patent 202,501
Patent Title: תכשירים המכילים מיקרו חלקיקים לשחרור מבוקר של טריפטולרין ושימוש בהם להכנת תרופה לטיפול בסרטן הערמונית (Pharmaceutical composition made of microparticles for controlled release of triptorelin and use thereof for the manufacture of a drug for the treatment of prostate cancer)

TRIPTODUR KIT is a drug marketed by Azurity. There is one patent protecting this drug.

This drug has forty-seven patent family members in thirty-two countries.

The generic ingredient in TRIPTODUR KIT is triptorelin pamoate. There are three drug master file entries for this API. Two suppliers are listed for this generic product. Additional details are available on the triptorelin pamoate profile page.

When can JAKAFI (ruxolitinib phosphate) generic drug versions launch?

Generic name: ruxolitinib phosphate
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 13, 2027
Generic Entry Controlled by: Israel Patent 202,524
Patent Title: מלחים של מדכא ג'אנוס קינאס (r)-3- (4-(7h-פירולו[d-3, 2]פירימידין -4-איל)-h 1-פיראזול-1-איל)-3-ציקלופנטילפרופאנאניטריל (Salts of the janus kinase inhibitor (r)-3-(4-(7 h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile)

JAKAFI is a drug marketed by Incyte Corp. There are eight patents protecting this drug and one Paragraph IV challenge.

This drug has two hundred and thirty-six patent family members in forty-six countries. There has been litigation on patents covering JAKAFI

See drug price trends for JAKAFI.

The generic ingredient in JAKAFI is ruxolitinib phosphate. There are two drug master file entries for this API. One supplier is listed for this generic product. Additional details are available on the ruxolitinib phosphate profile page.

When can JAKAFI (ruxolitinib phosphate) generic drug versions launch?

Generic name: ruxolitinib phosphate
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 13, 2027
Generic Entry Controlled by: Israel Patent 264,276
Patent Title: מלחים של מדכא ג'אנוס קינאס (r)- 3- (4-(h7-פירולו[d - 2,3]פירימידין-4-איל)-1h-פיראזול-1l-איל)-3-ציקלופנטילפרופאנאניטריל (Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-)

JAKAFI is a drug marketed by Incyte Corp. There are eight patents protecting this drug and one Paragraph IV challenge.

This drug has two hundred and thirty-six patent family members in forty-six countries. There has been litigation on patents covering JAKAFI

See drug price trends for JAKAFI.

The generic ingredient in JAKAFI is ruxolitinib phosphate. There are two drug master file entries for this API. One supplier is listed for this generic product. Additional details are available on the ruxolitinib phosphate profile page.

When can JAKAFI (ruxolitinib phosphate) generic drug versions launch?

Generic name: ruxolitinib phosphate
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 13, 2027
Generic Entry Controlled by: Israel Patent 280,401
Patent Title: מלחים של מדכא ג'אנוס קינאס (r)- 3- (4-(h7-פירולו[d - 2,3]פירימידין-4-איל)-1h-פיראזול-1l-איל)-3-ציקלופנטילפרופאנאניטריל (Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile)

JAKAFI is a drug marketed by Incyte Corp. There are eight patents protecting this drug and one Paragraph IV challenge.

This drug has two hundred and thirty-six patent family members in forty-six countries. There has been litigation on patents covering JAKAFI

See drug price trends for JAKAFI.

The generic ingredient in JAKAFI is ruxolitinib phosphate. There are two drug master file entries for this API. One supplier is listed for this generic product. Additional details are available on the ruxolitinib phosphate profile page.

When can ENTRESTO SPRINKLE (sacubitril; valsartan) generic drug versions launch?

Generic name: sacubitril; valsartan
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 18, 2027
Generic Entry Controlled by: Israel Patent 184,027
Patent Title: תרכובת טריסודיום [3-((1s, 3r)-1-ביפניל-4-ילמתיל-3-אתוקסיקרבוניל-1-בוטילקרבמויל)פרופיונאט-(s)-'3-מתיל-'2-(פנטהנויל{" 2-(טטרזול-5-ילאט)ביפניל-'4-ילמתיל}אמינו)בוטיראט] המיפנטההידראט, תכשירים רוקחיים שלה, שיטה להכנתה ושימוש בה להכנת תרופות (Compound trisodium [3-((1s,3r)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-(s)-3’-methyl-2’-(pentanoyl{2’’-(tetrazol-5-ylate)biphenyl-4’-ylmethyl}amino)butyrate] hemipentahydrate, its pharmaceutical compositions, method for its preparation and use thereof in the preparation of medicaments)

Drug Price Trends for ENTRESTO SPRINKLE
ENTRESTO SPRINKLE is a drug marketed by Novartis. There are three patents protecting this drug.

This drug has one hundred and eight patent family members in thirty-nine countries. There has been litigation on patents covering ENTRESTO SPRINKLE

See drug price trends for ENTRESTO SPRINKLE.

The generic ingredient in ENTRESTO SPRINKLE is sacubitril; valsartan. There are eleven drug master file entries for this API. Twenty-four suppliers are listed for this generic product. Additional details are available on the sacubitril; valsartan profile page.

When can KYBELLA (deoxycholic acid) generic drug versions launch?

Generic name: deoxycholic acid
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 19, 2027
Generic Entry Controlled by: Israel Patent 202,203
Patent Title: תכשיר חומצת מרה מלאכותי ושיטה להכנת החומצה (Synthetic bile acid composition and method for preparation of the bile acid)

KYBELLA is a drug marketed by Abbvie. There are fourteen patents protecting this drug and one Paragraph IV challenge.

This drug has one hundred and forty-six patent family members in thirty-eight countries. There has been litigation on patents covering KYBELLA

The generic ingredient in KYBELLA is deoxycholic acid. There are thirty-three drug master file entries for this API. One supplier is listed for this generic product. Additional details are available on the deoxycholic acid profile page.

When can OJEMDA (tovorafenib) generic drug versions launch?

Generic name: tovorafenib
DrugPatentWatch® Estimated Key Patent Expiration / Generic Entry Date: June 29, 2027
Generic Entry Controlled by: Israel Patent 202,835

OJEMDA is a drug marketed by Day One Biopharms. There are two patents protecting this drug.

This drug has fifty patent family members in twenty-seven countries.

The generic ingredient in OJEMDA is tovorafenib. One supplier is listed for this generic product. Additional details are available on the tovorafenib profile page.

Israel Drug Market: Patent Landscape and Regulatory Pathways

Last updated: February 19, 2026

This report analyzes the Israeli pharmaceutical market, focusing on patent protections, generic drug penetration, and the regulatory environment. It identifies key opportunities and challenges for both originator and generic drug manufacturers, and for investors evaluating R&D and market entry strategies. Israel's pharmaceutical sector is characterized by a robust innovation ecosystem, significant R&D investment, and a regulatory framework that balances intellectual property rights with public health access.

What is the Current State of the Israeli Pharmaceutical Market?

The Israeli pharmaceutical market is a significant player in the global healthcare landscape. It demonstrates strong growth driven by a high prevalence of chronic diseases, an aging population, and substantial government investment in healthcare infrastructure and research. The market is diverse, encompassing both innovative branded pharmaceuticals and a substantial generic drug segment.

Market Size and Growth

The Israeli pharmaceutical market was valued at approximately $5.2 billion in 2023 and is projected to reach $7.3 billion by 2028, exhibiting a compound annual growth rate (CAGR) of 7.2% for the forecast period (2023-2028) [1]. This growth is underpinned by an increasing demand for advanced medical treatments and a consistent rise in healthcare expenditure. The country’s advanced healthcare system, characterized by universal coverage provided by four competing health maintenance organizations (HMOs), facilitates widespread adoption of new therapies.

Key Therapeutic Areas

Major therapeutic areas driving market demand include oncology, cardiovascular diseases, central nervous system (CNS) disorders, immunology, and diabetes [2]. These segments benefit from significant R&D activities within Israel's vibrant life sciences sector, attracting both local and international investment.

Generic Drug Penetration

Israel has a well-established generic drug market, with generics accounting for a substantial portion of prescription drug sales by volume. The market penetration of generics is driven by cost-containment policies and the availability of a robust local generic manufacturing and distribution network. As of 2022, generics represent over 70% of the pharmaceutical market by volume [3]. This high penetration rate intensifies competition and necessitates strategic patent management for originator companies.

What are the Dominant Patent Protection Strategies in Israel?

Patent protection in Israel follows international standards, primarily governed by the Patents Law, 1967, and its subsequent amendments. The Israel Patent Office (ILPO) is responsible for examining and granting patents.

Patent Types and Enforcement

Pharmaceutical patents in Israel typically cover novel chemical entities, formulations, methods of treatment, and manufacturing processes. Patent term extension (PTE) mechanisms are available to compensate for patent term lost during the regulatory approval process, a critical consideration for originator drug companies seeking to maximize their market exclusivity.

  • Data Exclusivity: Israel provides a period of data exclusivity that runs concurrently with patent protection. For new chemical entities approved after January 1, 2000, a six-year data exclusivity period is granted. If the drug is also patented, the exclusivity period is extended to the longer of either the remaining patent term or 10 years from the date of first marketing authorization [4]. This dual protection is crucial for recouping R&D investments.
  • Patent Linkage: While Israel does not have a formal patent linkage system similar to the U.S. Hatch-Waxman Act, the ILPO's examination process and the subsequent regulatory approval by the Ministry of Health (MoH) indirectly influence generic market entry. Generic applicants must demonstrate that their product does not infringe existing valid patents.

Key Patent Litigation Trends

Patent litigation in Israel, particularly concerning pharmaceuticals, often revolves around infringement challenges and patent validity disputes. The courts are increasingly experienced in handling complex intellectual property cases, making robust patent prosecution and defense strategies essential. Settlement agreements between originators and generic manufacturers, similar to those seen in other developed markets, are also observed.

What are the Regulatory Opportunities and Challenges for Drug Manufacturers?

Navigating Israel's regulatory landscape presents both opportunities and challenges for pharmaceutical companies. The Ministry of Health (MoH) is the primary regulatory authority.

Regulatory Pathways for New Drugs

  • Marketing Authorization: Obtaining marketing authorization (MA) for new drugs involves submitting a comprehensive dossier to the MoH, including preclinical and clinical data, manufacturing information, and quality control data. The review process generally takes 12-18 months, depending on the complexity of the product and the completeness of the submission [5].
  • Fast-Track Review: Israel has implemented mechanisms to expedite the review of innovative medicines, particularly those addressing unmet medical needs or representing significant therapeutic advancements. This can shorten the time to market for novel drugs.

Generic Drug Approval Process

  • Abbreviated New Drug Application (ANDA) Equivalent: Generic drug approval requires demonstrating bioequivalence to the reference listed drug (RLD) and providing data on pharmaceutical quality. The MoH reviews these applications to ensure safety, efficacy, and quality. The process is generally efficient, contributing to the high generic penetration.
  • "Me-Too" Drugs: Israel also permits the registration of "me-too" drugs, which are similar to existing approved drugs. These require full dossiers but can be approved if they offer a therapeutic advantage or improved safety profile.

Pricing and Reimbursement

  • Price Control: The Israeli government employs a price control mechanism for pharmaceuticals, primarily through the Basket Committee, which determines the drugs included in the national health insurance basket. Drug prices are calculated based on a formula that considers prices in other developed countries, with a cap based on the average price in seven major OECD countries (U.S., UK, Germany, France, Italy, Spain, and Canada) [6]. This policy creates a challenging pricing environment for both originators and generics.
  • Reimbursement Negotiations: Companies must negotiate with the MoH and HMOs for inclusion in the national health insurance basket and for reimbursement rates. Successful negotiation is critical for market access and commercial success.

Opportunities

  • Innovation Hub: Israel's strong life sciences ecosystem, with numerous research institutions and a thriving biotech startup scene, presents opportunities for licensing, co-development, and acquisition of novel drug candidates.
  • Early Market Access: The MoH's willingness to consider innovative therapies and the existence of fast-track review pathways can provide early market access for breakthrough drugs.
  • Established Infrastructure: The well-developed healthcare and distribution infrastructure facilitates efficient market entry and patient access once regulatory approvals are secured.

Challenges

  • Price Controls: Strict price controls limit pricing flexibility and can impact profitability, particularly for high-cost innovative therapies.
  • Patent Litigation Complexity: Navigating patent disputes requires substantial legal resources and strategic planning.
  • Generic Competition: High generic penetration necessitates aggressive lifecycle management strategies for originator products and efficient market entry strategies for generics.
  • Regulatory Hurdles: While generally efficient, the regulatory review process can still be lengthy, and meeting the stringent data requirements for approval demands significant investment.
  • Global Harmonization: While Israel aligns with international standards, companies must adapt to specific local regulatory requirements and evolving policies.

What are the Intellectual Property Considerations for Market Entry and Exclusivity?

Understanding the intellectual property (IP) landscape is paramount for any company seeking to enter or compete in the Israeli pharmaceutical market. This includes both obtaining protection for new innovations and navigating existing IP rights.

Patent Filing and Strategy

  • National Phase Entry: Companies seeking patent protection in Israel for inventions originating from international patent applications (PCT) must enter the national phase within 30 months of the earliest priority date [7].
  • Provisional Patent Applications: While not explicitly defined as "provisional" in the same way as in the U.S., the Israeli patent system allows for the filing of patent applications that establish a priority date.
  • Utility Models: Israel does not have a separate system for utility models, similar to some other jurisdictions. Patent protection is the primary mechanism.
  • Freedom to Operate (FTO) Analysis: Before launching a new product or initiating R&D, a thorough FTO analysis is crucial to identify any potential infringement of existing Israeli patents. This analysis should encompass active pharmaceutical ingredients (APIs), formulations, manufacturing processes, and methods of use.

Patent Term and Extensions

  • Standard Patent Term: Patents in Israel are granted for a term of 20 years from the filing date of the application [8].
  • Patent Term Extension (PTE): As previously mentioned, Israel offers PTE to compensate for patent term lost due to the time required for obtaining marketing authorization from the MoH. The extension is calculated based on the period between the patent filing date and the first marketing authorization date, minus a deduction for administrative delays. The maximum extension is five years [4]. This provision is vital for ensuring a reasonable period of market exclusivity for innovative drugs.

Generic Patent Strategies

  • "Paragraph IV" Challenges (Analogous): While not formally termed "Paragraph IV," generic companies in Israel must consider how to challenge existing patents or design around them. This often involves detailed analysis of patent claims, prior art searches, and potential invalidity arguments.
  • Bioequivalence Studies: The core of a generic drug application is demonstrating bioequivalence to the RLD. This requires robust clinical studies that satisfy the MoH's requirements.
  • Process Patents: Generic manufacturers may seek to develop alternative manufacturing processes that do not infringe upon existing process patents held by originators.

Licensing and Collaboration

  • In-Licensing: Companies may license patented technologies or drug candidates from Israeli research institutions or biopharmaceutical companies to develop and commercialize them in Israel and globally.
  • Out-Licensing: Israeli companies with innovative IP may license their technologies to larger pharmaceutical firms for further development, clinical trials, and commercialization.
  • Joint Ventures: Collaborations and joint ventures are common, leveraging the strengths of different entities – for example, combining Israeli R&D expertise with the global commercialization capabilities of multinational corporations.

What are the Key Takeaways for R&D and Investment Decisions?

The Israeli pharmaceutical market offers a dynamic environment characterized by innovation, robust IP protection, and a structured regulatory framework, alongside significant pricing pressures and competitive generic forces.

  • Innovation Ecosystem: Israel's strong life sciences sector provides a rich source of novel drug candidates and collaborative opportunities for R&D investment and business development.
  • Patent Strength and Strategy: Originator companies must implement comprehensive patent filing and enforcement strategies, including leveraging PTE, to protect their market exclusivity. Generics must conduct thorough FTO analyses and develop effective patent circumvention or challenge strategies.
  • Regulatory Navigation: A deep understanding of the MoH's approval processes, data exclusivity provisions, and pricing/reimbursement mechanisms is critical for both originator and generic drug success.
  • Pricing Environment: The government's price control policies create a challenging commercial landscape, necessitating careful market forecasting and cost management.
  • Generic Market Dominance: The high volume of generic drug sales underscores the need for originators to maximize their exclusivity periods and for generics to focus on efficient R&D, manufacturing, and market entry.

Frequently Asked Questions

1. How does Israel's data exclusivity period compare to that of other major markets like the United States and the European Union?

Israel's six-year data exclusivity period for new chemical entities is shorter than the U.S. (five years for new chemical entities, with potential extensions) and the EU (eight years of data exclusivity plus two years of market exclusivity, extendable to 11 years). However, Israel's provision for extending exclusivity to 10 years from the date of first marketing authorization if the patent term has not expired offers a degree of market protection comparable in practice for some products [4, 9, 10].

2. What is the typical timeline for obtaining marketing authorization for a new drug in Israel?

The typical timeline for obtaining marketing authorization for a new drug in Israel ranges from 12 to 18 months. However, the Ministry of Health offers expedited review pathways for innovative medicines, which can significantly shorten this period for drugs addressing unmet medical needs or representing major therapeutic advancements [5].

3. Are there specific incentives for R&D investment in the Israeli pharmaceutical sector?

Yes, Israel offers various incentives for R&D, including tax benefits, grants from the Israel Innovation Authority (formerly the Office of the Chief Scientist), and support for establishing R&D centers. These incentives aim to foster innovation and attract both domestic and foreign investment in the life sciences [11].

4. How does the price control mechanism in Israel impact the pricing of patented versus generic drugs?

The price control mechanism in Israel applies to both patented and generic drugs, setting reference prices based on international benchmarks and domestic cost considerations. While originators face stringent price ceilings, generics also operate within a framework that emphasizes affordability, contributing to intense price competition once exclusivity periods expire [6].

5. What are the implications of the ongoing global efforts towards pharmaceutical price transparency on the Israeli market?

Global trends towards greater price transparency can influence the Israeli pricing framework. The country’s price referencing system, which relies on prices in other developed nations, means that increased transparency and potential price reductions in those markets could exert downward pressure on prices in Israel. Companies must monitor international pricing dynamics closely [6].


Citations

[1] Mordor Intelligence. (2023). Israel Pharmaceutical Market - Growth, Trends, COVID-19 Impact, and Forecasts (2023 - 2028). [2] GlobalData. (2023). Pharmaceutical Market Outlook: Israel. [3] Eretz. (2022, October 12). The pharmaceutical market in Israel. Eretz. [4] Israel Patent Office. (n.d.). Patent Term Extension. Retrieved from the Israel Patent Office website. [5] Ministry of Health, Israel. (n.d.). Pharmaceutical Registration. Retrieved from the Ministry of Health website. [6] Ministry of Health, Israel. (2019). The Health Basket for 2020. [7] World Intellectual Property Organization. (n.d.). Israel. In PCT National Entry Information. [8] Israel Patent Office. (n.d.). Patents Law, 1967. [9] U.S. Food and Drug Administration. (n.d.). Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations. [10] European Medicines Agency. (n.d.). European drug regulatory system. [11] Israel Innovation Authority. (n.d.). R&D Programs. Retrieved from the Israel Innovation Authority website.

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