Investigational Drug Information for Guadecitabine
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What is the drug development status for Guadecitabine?
Guadecitabine is an investigational drug.
There have been 28 clinical trials for Guadecitabine.
The most recent clinical trial was a Phase 3 trial, which was initiated on March 16th 2017.
The most common disease conditions in clinical trials are Leukemia, Myeloid, Acute, Leukemia, and Preleukemia. The leading clinical trial sponsors are Astex Pharmaceuticals, Astex Pharmaceuticals, Inc., and National Cancer Institute (NCI).
There are four US patents protecting this investigational drug and fifty-eight international patents.
Summary for Guadecitabine
| US Patents | 4 |
| International Patents | 58 |
| US Patent Applications | 22 |
| WIPO Patent Applications | 13 |
| Japanese Patent Applications | 9 |
| Clinical Trial Progress | Phase 3 (2017-03-16) |
| Vendors | 22 |
Recent Clinical Trials for Guadecitabine
| Title | Sponsor | Phase |
|---|---|---|
| A Phase II Study of Cladribine and Low Dose Cytarabine in Combination With Venetoclax, Alternating With Azacitidine and Venetoclax, in Patients With Higher-risk Myeloproliferative Chronic Myelomonocytic Leukemia or Higher-risk Myelodysplastic Syndro | M.D. Anderson Cancer Center | Phase 2 |
| Testing the Combination of Belinostat and SGI-110 (Guadecitabine) or ASTX727 for the Treatment of Unresectable and Metastatic Conventional Chondrosarcoma | National Cancer Institute (NCI) | Phase 2 |
| A Study of NIVO Plus IPI and Guadecitabine or NIVO Plus IPI in Melanoma and NSCLC Resistant to Anti-PD1/PDL1 | Astex Pharmaceuticals, Inc. | Phase 2 |
Clinical Trial Summary for Guadecitabine
Top disease conditions for Guadecitabine
Top clinical trial sponsors for Guadecitabine
US Patents for Guadecitabine
| Drugname | Patent Number | Patent Title | Patent Assignee | Estimated Expiration |
|---|---|---|---|---|
| Guadecitabine | ⤷ Try a Trial | Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors | Boehringer Ingelheim International GmbH (Ingelheim am Rhein, DE) | ⤷ Try a Trial |
| Guadecitabine | ⤷ Try a Trial | Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors | Boehringer Ingelheim International GmbH (Ingelheim am Rhein, DE) | ⤷ Try a Trial |
| Guadecitabine | ⤷ Try a Trial | Polymorphic forms of 3-[(2-butyl-1-(2-diethylamino-ethyl)-1H-benzoimidazol-5-yl]-N-hydroxy-acr- ylamide and uses thereof | MEI PHARMA, INC. (San Diego, CA) | ⤷ Try a Trial |
| Guadecitabine | ⤷ Try a Trial | Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors | Boehringer Ingelheim International GmbH (Ingelheim am Rhein, DE) | ⤷ Try a Trial |
| >Drugname | >Patent Number | >Patent Title | >Patent Assignee | >Estimated Expiration |
International Patents for Guadecitabine
| Drugname | Country | Document Number | Estimated Expiration | Related US Patent |
|---|---|---|---|---|
| Guadecitabine | European Patent Office | EP3129380 | 2034-04-11 | ⤷ Try a Trial |
| Guadecitabine | Japan | JP2017510610 | 2034-04-11 | ⤷ Try a Trial |
| Guadecitabine | Japan | JP6577958 | 2034-04-11 | ⤷ Try a Trial |
| Guadecitabine | World Intellectual Property Organization (WIPO) | WO2015155332 | 2034-04-11 | ⤷ Try a Trial |
| >Drugname | >Country | >Document Number | >Estimated Expiration | >Related US Patent |
