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Last Updated: April 20, 2024

CLINICAL TRIALS PROFILE FOR ZIBOTENTAN

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Clinical Trials for Zibotentan

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Trial ID	Title	Status	Sponsor	Phase	Summary
NCT00055471 ↗	A Phase IIa. Open-label, Multicenter, Dose-escalation Study to Assess the Tolerability and Pharmacokinetics of ZD4054 (Zibotentan) Given Orally Once Daily in Subjects With Metastatic Prostate Cancer	Completed	AstraZeneca	Phase 2	The primary purpose of this study is to determine the safest dose of ZD4054 (Zibotentan)in men with prostate cancer
NCT00090363 ↗	ZD4054 (Zibotentan) in Pain-free or Mildly Symptomatic Patients With Prostate Cancer and Bone Metastases Who Have Rising Serum Prostate Specific Antigen (PSA)	Completed	AstraZeneca	Phase 2	This study is being carried out to see if ZD4054 (Zibotentan) is effective in treating prostate cancer and spread of cancer to the bone, and if so, how it compares with placebo (sugar pill). The study will also provide further information on the safety of ZD4054 (Zibotentan).
NCT00314782 ↗	Phase I Study of ZD4054 (Zibotentan) and Docetaxel in Patients With Metastatic HRPC	Completed	AstraZeneca	Phase 1	Two-part, multi-center study design to establish a maximum tolerated dose (MTD) of ZD4054 in combination with docetaxel and to explore its safety, tolerability, pharmacokinetic (PK) profiles and clinical efficacy in patients with metastatic hormone-refractory prostate cancer (HRPC)
>Trial ID	>Title	>Status	>Sponsor	>Phase	>Summary

Clinical Trial Conditions for Zibotentan

Condition Name

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Condition Name for
Intervention	Trials
Prostate Cancer	5
Healthy	3
Chronic Kidney Disease	3
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Condition MeSH

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Condition MeSH for
Intervention	Trials
Prostatic Neoplasms	6
Renal Insufficiency, Chronic	4
Kidney Diseases	4
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Clinical Trial Locations for Zibotentan

Trials by Country

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Trials by Country for
Location	Trials
United States	93
Japan	41
Brazil	26
United Kingdom	25
Canada	24
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Trials by US State

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Trials by US State for
Location	Trials
Ohio	6
South Carolina	5
Maryland	5
Florida	5
California	5
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Clinical Trial Progress for Zibotentan

Clinical Trial Phase

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Clinical Trial Phase for
Clinical Trial Phase	Trials
Phase 3	3
Phase 2	13
Phase 1	10
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Clinical Trial Status

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Clinical Trial Status for
Clinical Trial Phase	Trials
Completed	15
Not yet recruiting	5
Recruiting	2
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Clinical Trial Sponsors for Zibotentan

Sponsor Name

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Sponsor Name for
Sponsor	Trials
AstraZeneca	20
Papworth Hospital NHS Foundation Trust	2
Cardiff University	2
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Sponsor Type

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Sponsor Type for
Sponsor	Trials
Industry	22
Other	20
NIH	1
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