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CLINICAL TRIALS PROFILE FOR TAK-228

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Clinical Trials for TAK-228

Trial ID	Title	Status	Sponsor	Phase	Summary
NCT00034281	Safety and Tolerability Study of TAK-165 in Subjects With Tumors Expressing HER2	Completed	Takeda	Phase 1	The purpose of this study is to investigate a safe dose of TAK-165, once daily (QD), in patients with HER2-tumor expression.
NCT00143611	Efficacy & Safety of Resatorvid in Adults With Severe Sepsis	Completed	Takeda	Phase 3	The purpose of this study is to determine the optimal dose of Resatorvid for reducing 28-day all-cause mortality in subjects with severe sepsis.
NCT00143663	Effect of Lapaquistat Acetate on Blood Cholesterol Levels in Subjects With Elevated Cholesterol	Completed	Takeda	Phase 3	The purpose of this study is to determine if patients with elevated cholesterol, but not taking any other lipid medication, could lower their cholesterol with administration of lapaquistat acetate, once daily (QD).
NCT00143676	Efficacy of Lapaquistat Acetate and Atorvastatin on Blood Cholesterol Levels in Subjects With Primary Hypercholesterolemia	Completed	Takeda	Phase 3	The purpose of this study is to determine the efficacy of lapaquistat acetate, once daily (QD), on lowering cholesterol in subjects already taking atorvastatin.
NCT00229437	Efficacy and Safety Study of TAK-128 in Treating Subjects With Diabetic Peripheral Neuropathy	Completed	Takeda	Phase 2	The purpose of this study is to determine the efficacy and safety of TAK-128, once daily (QD), in treating subjects with diabetic peripheral neuropathy.

Clinical Trial Conditions for TAK-228

Condition Name

Condition Name for
Intervention	Trials
Healthy Volunteers	41
Hypertension	17
Prostate Cancer	14
Diabetes Mellitus	11

Condition MeSH

Condition MeSH for
Intervention	Trials
Diabetes Mellitus	30
Hypertension	27
Diabetes Mellitus, Type 2	21
Neoplasms	17

Clinical Trial Locations for TAK-228

Trials by Country

Trials by Country for
Location	Trials
Japan	597
China	90
Canada	85
United Kingdom	74
Mexico	63

Trials by US State

Trials by US State for
Location	Trials
Texas	87
California	83
Florida	70
Ohio	66
New York	57

Clinical Trial Progress for TAK-228

Clinical Trial Phase

Clinical Trial Phase for
Clinical Trial Phase	Trials
Phase 4	4
Phase 3	103
Phase 2/Phase 3	2

Clinical Trial Status

Clinical Trial Status for
Clinical Trial Phase	Trials
Completed	147
Not yet recruiting	97
Recruiting	54

Clinical Trial Sponsors for TAK-228

Sponsor Name

Sponsor Name for
Sponsor	Trials
Takeda	238
Millennium Pharmaceuticals, Inc.	79
National Cancer Institute (NCI)	20

Sponsor Type

Sponsor Type for
Sponsor	Trials
Industry	329
Other	44
NIH	22