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Last Updated: September 19, 2020

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CLINICAL TRIALS PROFILE FOR KYNURENIC ACID

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Clinical Trials for Kynurenic Acid

Trial ID Title Status Sponsor Phase Summary
NCT02067975 Tryptophan MRI in People With Schizophrenia and Healthy Controls Recruiting Mitsubishi Tanabe Pharma Corporation Phase 2/Phase 3 Kynurenic acid (KYNA) is a naturally occurring chemical in the brain. Studies with rodents indicate that levels of KYNA can impact levels of the neurotransmitters glutamate and dopamine. One way to reliably increase KYNA levels is by ingesting the amino acid tryptophan. Tryptophan is a normal part of the human diet. Tryptophan gets metabolized/changed to other chemicals in the body- including KYNA. By giving people 6 grams of tryptophan, the investigators will be able to increase the KYNA level in a controlled way. The investigators will then be able to study the effects of KYNA on neurotransmitters by using cognitive tests and magnetic resonance imaging techniques (measuring brain activity and brain chemistry using the MRI magnet). They will test people using tryptophan and also using a placebo to look for differences. The investigators will test healthy controls and people with schizophrenia to look for differences.
NCT02067975 Tryptophan MRI in People With Schizophrenia and Healthy Controls Recruiting National Institute of Mental Health (NIMH) Phase 2/Phase 3 Kynurenic acid (KYNA) is a naturally occurring chemical in the brain. Studies with rodents indicate that levels of KYNA can impact levels of the neurotransmitters glutamate and dopamine. One way to reliably increase KYNA levels is by ingesting the amino acid tryptophan. Tryptophan is a normal part of the human diet. Tryptophan gets metabolized/changed to other chemicals in the body- including KYNA. By giving people 6 grams of tryptophan, the investigators will be able to increase the KYNA level in a controlled way. The investigators will then be able to study the effects of KYNA on neurotransmitters by using cognitive tests and magnetic resonance imaging techniques (measuring brain activity and brain chemistry using the MRI magnet). They will test people using tryptophan and also using a placebo to look for differences. The investigators will test healthy controls and people with schizophrenia to look for differences.
NCT02067975 Tryptophan MRI in People With Schizophrenia and Healthy Controls Recruiting University of Maryland Phase 2/Phase 3 Kynurenic acid (KYNA) is a naturally occurring chemical in the brain. Studies with rodents indicate that levels of KYNA can impact levels of the neurotransmitters glutamate and dopamine. One way to reliably increase KYNA levels is by ingesting the amino acid tryptophan. Tryptophan is a normal part of the human diet. Tryptophan gets metabolized/changed to other chemicals in the body- including KYNA. By giving people 6 grams of tryptophan, the investigators will be able to increase the KYNA level in a controlled way. The investigators will then be able to study the effects of KYNA on neurotransmitters by using cognitive tests and magnetic resonance imaging techniques (measuring brain activity and brain chemistry using the MRI magnet). They will test people using tryptophan and also using a placebo to look for differences. The investigators will test healthy controls and people with schizophrenia to look for differences.
NCT02340325 FS2 Safety and Tolerability Study in Healthy Volunteers Completed British Columbia Professional Firefighters' Burn and Wound Healing Laboratory Phase 1 Background Scarring typically occurs after trauma, burn injury or surgery. Hypertrophic scarring presents as raised, red and itchy lesions which variably respond to various treatment modalities, such as corticosteroids, pressure garments, laser therapy, the use of silicone sheets and radiotherapy. Kynurenine, or "Fibrostop 1" (FS1), and its further breakdown products, such as kynurenic acid, or "Fibrostop 2" (FS2), are endogenous products found in many systems and have shown potential in reducing scar formation in animal studies. The aim of study is to evaluate the safety and tolerability of FS2 cream applied to the skin of healthy human subjects.
NCT03513822 Ketamine's Efficiency in the Treatment of Chronic Pain: Kynurenin Pathway Recruiting Fondation Apicil Phase 3 The kynurenine pathway is involved in hyperalgesia. This pathway is activated by inflammation. Ketamine would interact with the kynurenine pathway and inflammation. Our working hypotheses are: the clinical effects of ketamine on neuropathic pain are greater in the presence of systemic inflammation and the mechanism of action involves an interaction on the kynurenine pathway. Study design: Interventional randomized placebo-controlled clinical trial. Main goals: 1. To show a better clinical efficacy of ketamine in chronic pain in patients with an inflammatory component. 2. Explore the anti-inflammatory activity of ketamine through the Kynurenine pathway.
NCT03513822 Ketamine's Efficiency in the Treatment of Chronic Pain: Kynurenin Pathway Recruiting Hopital Lariboisière Phase 3 The kynurenine pathway is involved in hyperalgesia. This pathway is activated by inflammation. Ketamine would interact with the kynurenine pathway and inflammation. Our working hypotheses are: the clinical effects of ketamine on neuropathic pain are greater in the presence of systemic inflammation and the mechanism of action involves an interaction on the kynurenine pathway. Study design: Interventional randomized placebo-controlled clinical trial. Main goals: 1. To show a better clinical efficacy of ketamine in chronic pain in patients with an inflammatory component. 2. Explore the anti-inflammatory activity of ketamine through the Kynurenine pathway.
>Trial ID >Title >Status >Phase >Summary

Clinical Trial Conditions for Kynurenic Acid

Condition Name

Condition Name for
Intervention Trials
Schizophrenia 2
Schizoaffective Disorder 1
Neuralgia 1
Keloid 1
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Condition MeSH

Condition MeSH for
Intervention Trials
Schizophrenia 2
Inflammation 1
Chronic Pain 1
Hypertrophy 1
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Clinical Trial Locations for Kynurenic Acid

Trials by Country

Trials by Country for
Location Trials
United States 2
France 1
Canada 1
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Trials by US State

Trials by US State for
Location Trials
Maryland 2
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Clinical Trial Progress for Kynurenic Acid

Clinical Trial Phase

Clinical Trial Phase for
Clinical Trial Phase Trials
Phase 3 1
Phase 2/Phase 3 1
Phase 1/Phase 2 1
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Clinical Trial Status

Clinical Trial Status for
Clinical Trial Phase Trials
Recruiting 2
Not yet recruiting 1
Completed 1
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Clinical Trial Sponsors for Kynurenic Acid

Sponsor Name

Sponsor Name for
Sponsor Trials
University of Maryland 2
Hopital Lariboisière 1
Fondation Apicil 1
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Sponsor Type

Sponsor Type for
Sponsor Trials
Other 10
NIH 1
Industry 1
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