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Last Updated: May 8, 2024

CLINICAL TRIALS PROFILE FOR FOLIGLURAX


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Clinical Trials for Foliglurax

Trial ID Title Status Sponsor Phase Summary
NCT03162874 ↗ Study to Evaluate the Efficacy, Safety and Tolerability of PXT002331 (Foliglurax) in Reducing Motor Complications of Levodopa Therapy in Parkinson Disease's Patients Completed Prexton Therapeutics Phase 2 This will be a double-blind, randomised, placebo-controlled parallel-arm phase II proof of concept in subjects with PD treated with a stable dose of levodopa who are experiencing both end-of-dose wearing off and Levodopa-Induced Dyskinesia (LID)
NCT03331848 ↗ Study to Evaluate the Efficacy, Safety, and Tolerability of PXT002331 (Foliglurax) in Reducing Levodopa-Induced Dyskinesia and Wearing OFF in Subjects With Parkinson's Disease Experiencing Motor Complications of Levodopa Therapy (ATTUNED) Withdrawn Prexton Therapeutics Phase 2 This is a Multi-center, Double-blind, Randomized, Placebo-controlled, Parallel-arm Phase IIa proof of concept in subjects with PD treated with a stable dose of levodopa who are experiencing Motor Complications of Levodopa Therapy
NCT04002895 ↗ What the Body Does to Foliglurax in Healthy Volunteers Completed H. Lundbeck A/S Phase 1 This study evaluates how the body takes up and gets rid of foliglurax after swallowing a liquid dose.
NCT04175132 ↗ Binding of Foliglurax to Regions in the Brain in Healthy Participants and in Patients With Parkinson's Disease (PD) Terminated H. Lundbeck A/S Phase 1 A study to learn how foliglurax binds in regions of the brain
NCT04275115 ↗ Effects of Repeated Doses of Foliglurax on Drug Metabolizing Enzymes in Healthy Subjects Completed H. Lundbeck A/S Phase 1 The purpose of this study is to help determine which types of drugs that may interact with foliglurax
NCT04322227 ↗ Study Investigating Effects of Foliglurax in Patients With Parkinson's Disease (PD) and Healthy Subjects Terminated H. Lundbeck A/S Phase 1 The purpose of this study is to investigate effects of foliglurax on brain wave patterns (electric signals) in healthy subjects and in patients with PD
>Trial ID >Title >Status >Phase >Summary

Clinical Trial Conditions for Foliglurax

Condition Name

Condition Name for
Intervention Trials
Healthy 4
Parkinson Disease 4
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Condition MeSH

Condition MeSH for
Intervention Trials
Parkinson Disease 4
Dyskinesias 1
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Clinical Trial Locations for Foliglurax

Trials by Country

Trials by Country for
Location Trials
France 3
United Kingdom 2
Germany 1
Spain 1
Austria 1
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Clinical Trial Progress for Foliglurax

Clinical Trial Phase

Clinical Trial Phase for
Clinical Trial Phase Trials
Phase 2 2
Phase 1 4
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Clinical Trial Status

Clinical Trial Status for
Clinical Trial Phase Trials
Completed 3
Terminated 2
Withdrawn 1
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Clinical Trial Sponsors for Foliglurax

Sponsor Name

Sponsor Name for
Sponsor Trials
H. Lundbeck A/S 4
Prexton Therapeutics 2
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Sponsor Type

Sponsor Type for
Sponsor Trials
Industry 6
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