Anemia Studies in Chronic Kidney Disease: Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor Daprodustat-Non-Dialysis (ASCEND-ND)
The purpose of this multi-center event-driven study in non-dialysis (ND) participants with
anemia associated with chronic kidney disease (CKD) is to evaluate the safety and efficacy
of daprodustat compared to darbepoetin alfa.
A Study to Evaluate Efficacy and Safety of Daprodustat Compared to Darbepoetin Alfa in Japanese Hemodialysis (HD)-Dependent Subjects With Anemia Associated With Chronic Kidney Disease (CKD)
Daprodustat is a drug that is currently being developed as a treatment for renal anemia .
This study is to evaluate the efficacy and safety of daprodustat following a switch from
erythropoiesis-stimulating agent (ESA) in Japanese HD subjects with renal anemia who are
currently treated with ESA. The primary objective is to demonstrate non-inferiority of
daprodustat to darbepoetin alfa. This study is a 52-week, Phase III, double-blind,
active-controlled, parallel-group, multi-center study. The total duration of the study will
be approximately 58 weeks including screening and follow-up.
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