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Last Updated: April 20, 2024

CLINICAL TRIALS PROFILE FOR CHIAURANIB

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Clinical Trials for Chiauranib

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Trial ID	Title	Status	Sponsor	Phase	Summary
NCT02122809 ↗	Phase I Study of Chiauranib in Patients With Advanced Solid Tumors	Completed	Chipscreen Biosciences, Ltd.	Phase 1	The purpose of this dose-escalation study is to assess the safety and tolerability of treatment with Chiauranib administered orally over a range of doses in patients with advanced solid tumors.
NCT03074825 ↗	Study of Chiauranib in Relapsed/Refractory Non-Hodgkin's Lymphoma	Terminated	Chipscreen Biosciences, Ltd.	Phase 1	Chiauranib may stop the growth of tumor cells by blocking Aurora kinase B（Aurora B）、VEGFR/PDGFR/c-Kit、CSF-1R targets. This clinical trial is studying the efficacy and safety of chiauranib works in treating patients with relapsed or refractory non-Hodgkin's lymphoma, in the meantime, exploring the latent biomarkers accompany with chiauranib, as well as the relevancy of which and clinical benefit.
NCT03166891 ↗	Phase Ib Study of Chiauranib in Patients With Ovarian Cancer	Completed	Chipscreen Biosciences, Ltd.	Phase 1/Phase 2	Chiauranib may stop the growth of tumor cells by blocking Aurora kinase B（Aurora B）、VEGFR/PDGFR/c-Kit、CSF-1R targets. This clinical trial is studying the efficacy and safety of chiauranib(50mg，QD，PO) works in treating patients with relapsed or refractory ovarian cancer, in the meantime, exploring the latent biomarkers accompany with chiauranib, as well as the relevancy of which and clinical benefit.
NCT03216343 ↗	Phase Ib Study of Chiauranib in Patients With Small Cell Lung Cancer	Unknown status	Chipscreen Biosciences, Ltd.	Phase 1	Chiauranib , which simultaneously targets against VEGFR/Aurora B/CSF-1R, several key kinases involved in tumor angiogenesis, tumor cell mitosis, and chronic inflammatory microenvironment.
NCT03245190 ↗	Study of Chiauranib in Patients With Advanced Hepatocellular Carcinoma	Completed	Chipscreen Biosciences, Ltd.	Phase 1/Phase 2	Chiauranib, which simultaneously targets against VEGFR/Aurora B/CSF-1R, several key kinases involved in tumor angiogenesis, tumor cell mitosis, and chronic inflammatory microenvironment.
NCT03901118 ↗	Chiauranib in Combination With Chemotherapy in Patients With Ovarian Cancer	Completed	Chipscreen Biosciences, Ltd.	Phase 2	This clinical trial will evaluate the efficacy and safety of chiauranib added to chemotherapy in patients with relapsed or refractory ovarian cancer, in the meantime, explore the pharmacokinetics characteristic after the combined treatment.
NCT03974243 ↗	Chiauranib in Combination With Chidamide in Patients With Relapsed/Refractory Non-Hodgkin's Lymphoma	Recruiting	Chipscreen Biosciences, Ltd.	Phase 1/Phase 2	The purpose of this dose-escalation study is to assess the safety and tolerability of treatment with Chiauranib and Chidamide administered orally over a range of doses in patients with relapsed or refractory non-Hodgkin's lymphoma, in the meantime, exploring the pharmacodynamic profile and latent biomarkers accompany with Chiauranib and Chidamide , as well as the relevancy of which and clinical benefit.
>Trial ID	>Title	>Status	>Sponsor	>Phase	>Summary

Clinical Trial Conditions for Chiauranib

Condition Name

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Condition Name for
Intervention	Trials
Small Cell Lung Cancer	3
Ovarian Cancer	3
Soft Tissue Sarcoma	2
Non-Hodgkin's Lymphoma	2
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Condition MeSH

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Condition MeSH for
Intervention	Trials
Small Cell Lung Carcinoma	5
Lung Neoplasms	4
Ovarian Neoplasms	3
Carcinoma, Ovarian Epithelial	3
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Clinical Trial Locations for Chiauranib

Trials by Country

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Trials by Country for
Location	Trials
China	17
United States	1
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Trials by US State

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Trials by US State for
Location	Trials
Ohio	1
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Clinical Trial Progress for Chiauranib

Clinical Trial Phase

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Clinical Trial Phase for
Clinical Trial Phase	Trials
Phase 3	2
Phase 2	4
Phase 1/Phase 2	5
[disabled in preview]	5
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Clinical Trial Status

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Clinical Trial Status for
Clinical Trial Phase	Trials
Recruiting	6
Completed	4
Not yet recruiting	4
[disabled in preview]	2
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Clinical Trial Sponsors for Chiauranib

Sponsor Name

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Sponsor Name for
Sponsor	Trials
Chipscreen Biosciences, Ltd.	15
Medelis Inc.	1
H & J CRO International, Inc.	1
[disabled in preview]	3
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Sponsor Type

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Sponsor Type for
Sponsor	Trials
Industry	18
Other	2
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