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Last Updated: August 11, 2022

CLINICAL TRIALS PROFILE FOR BEVASIRANIB


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Clinical Trials for Bevasiranib

Trial ID Title Status Sponsor Phase Summary
NCT00259753 ↗ Safety and Efficacy Study of Small Interfering Ribonucleic Acid (RNA) Molecule (Cand5) to Treat Wet Age-Related Macular Degeneration Completed OPKO Health, Inc. Phase 2 The objective of this study is to evaluate the safety and preliminary efficacy of three doses of Cand5. Cand5, a small interfering RNA molecule that selectively silences the mRNA encoding for VEGF.
NCT00306904 ↗ Safety and Efficacy Study of Small Interfering RNA Molecule (Cand5) to Treat Diabetic Macular Edema Completed OPKO Health, Inc. Phase 2 The purpose of this study is to evaluate the pharmacokinetics, safety and preliminary efficacy of 3 doses of Cand5. Cand5 is a small interfering RNA molecule that selectively silences the mRNA encoding for VEGF. The target population are patients with diabetic macular edema.
NCT00499590 ↗ Safety & Efficacy Study Evaluating the Combination of Bevasiranib & Lucentis Therapy in Wet AMD Terminated OPKO Health, Inc. Phase 3 The purpose of this study is to compare the safety and effectiveness of bevasiranib given either every 8 weeks or every 12 weeks after an initial pre-treatment with 3 injections of Lucentis┬« (ranibizumab injection) compared to Lucentis┬« given every 4 weeks to people with wet AMD. Patients will be assigned at random (like tossing a coin) to receive one of three treatments options for 104 weeks.
NCT00557791 ↗ Safety & Efficacy Study Evaluating the Combination of Bevasiranib & Lucentis Therapy in Wet AMD (CARBON) Withdrawn OPKO Health, Inc. Phase 3 The purpose of this study is to compare the safety and effectiveness of three doses of intravitreal bevasiranib sodium as maintenance therapy for Age-Related Macular Degeneration following initiation of anti-VEGF therapy with three doses of Lucentis┬«.
NCT00722384 ↗ Open Label Study for the Evaluation of Tolerability of Five Dose Levels of Cand5 Completed OPKO Health, Inc. Phase 1 To establish the tolerability and preliminary efficacy of Cand5 by a single intravitreal injection in patients with wet age-related macular degeneration.
>Trial ID >Title >Status >Phase >Summary

Clinical Trial Conditions for Bevasiranib

Condition Name

Condition Name for
Intervention Trials
Macular Degeneration 3
Age Related Macular Degeneration 1
Diabetic Macular Edema 1
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Condition MeSH

Condition MeSH for
Intervention Trials
Macular Degeneration 4
Choroidal Neovascularization 1
Macular Edema 1
Edema 1
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Clinical Trial Locations for Bevasiranib

Trials by Country

Trials by Country for
Location Trials
United States 40
Canada 3
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Trials by US State

Trials by US State for
Location Trials
New Jersey 3
Ohio 3
California 2
South Dakota 2
Arizona 2
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Clinical Trial Progress for Bevasiranib

Clinical Trial Phase

Clinical Trial Phase for
Clinical Trial Phase Trials
Phase 3 2
Phase 2 2
Phase 1 1
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Clinical Trial Status

Clinical Trial Status for
Clinical Trial Phase Trials
Completed 3
Terminated 1
Withdrawn 1
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Clinical Trial Sponsors for Bevasiranib

Sponsor Name

Sponsor Name for
Sponsor Trials
OPKO Health, Inc. 5
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Sponsor Type

Sponsor Type for
Sponsor Trials
Industry 5
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