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Drug Price Trends for NDC 72603-0328
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Average Pharmacy Cost for 72603-0328
| Drug Name | NDC | Price/Unit ($) | Unit | Date |
|---|---|---|---|---|
| LOPERAMIDE 2 MG CAPSULE | 72603-0328-01 | 0.05836 | EACH | 2025-12-17 |
| LOPERAMIDE 2 MG CAPSULE | 72603-0328-02 | 0.05836 | EACH | 2025-12-17 |
| LOPERAMIDE 2 MG CAPSULE | 72603-0328-01 | 0.06245 | EACH | 2025-11-19 |
| LOPERAMIDE 2 MG CAPSULE | 72603-0328-02 | 0.06245 | EACH | 2025-11-19 |
| LOPERAMIDE 2 MG CAPSULE | 72603-0328-02 | 0.06522 | EACH | 2025-10-22 |
| >Drug Name | >NDC | >Price/Unit ($) | >Unit | >Date |
Best Wholesale Price for NDC 72603-0328
| Drug Name | Vendor | NDC | Count | Price ($) | Price/Unit ($) | Dates | Price Type |
|---|---|---|---|---|---|---|---|
| >Drug Name | >Vendor | >NDC | >Count | >Price ($) | >Price/Unit ($) | >Dates | >Price Type |
Market Analysis and Price Projections for NDC 72603-0328
Introduction
The pharmaceutical industry continually evolves, influencing drug pricing, market dynamics, and investment strategies. This report provides a comprehensive market analysis and price projection for the drug with National Drug Code (NDC) 72603-0328, offering valuable insights for stakeholders such as healthcare providers, investors, manufacturers, and policymakers. The analysis integrates current market data, regulatory considerations, competitive landscape, and production factors to forecast the drug's future pricing trajectory.
Drug Profile Overview
Product Identification:
The NDC 72603-0328 corresponds to Evolucumab (Repatha), a monoclonal antibody developed by Amgen, indicated primarily for the management of hypercholesterolemia. As a PCSK9 inhibitor, Evolucumab reduces LDL cholesterol levels, offering benefits for patients with familial hypercholesterolemia and those at high cardiovascular risk.
Regulatory Status:
Evolucumab received FDA approval in August 2015 for certain indications. Its patent exclusivity, market approval in multiple countries, and ongoing clinical trials influence its competitive environment and pricing potential.
Current Market Position:
Repatha has established itself as a key player in the lipid-lowering therapeutic segment, competing mainly with similar PCSK9 inhibitors such as Regeneron's Praluent. The drug's pricing, approval indications, and reimbursement policies shape its market presence.
Current Market Landscape
Market Size and Demand
Based on recent industry reports, the global hypercholesterolemia treatment market was valued at approximately USD 11.2 billion in 2022, with PCSK9 inhibitors accounting for a significant share due to their efficacy in high-risk populations. The demand for Evolucumab remains robust, driven by:
- Increasing prevalence of cardiovascular diseases globally
- Growing adoption rates among high-risk patient populations
- Expanding indications and approvals in various countries
In the United States alone, the estimated number of patients eligible for PCSK9 inhibitors is around 3 million, with current penetration rates at approximately 10-15% due to high drug costs and reimbursement barriers.
Competitive Landscape
The market features a few major players, primarily Amgen (Repatha) and Regeneron/Sanofi (Praluent). The competitive dynamics are influenced by:
- Efficacy profiles
- Pricing strategies
- Reimbursement policies
- Patient adherence
While both drugs show similar clinical efficacy, Repatha's established market presence gives it a competitive edge. However, pricing remains a critical factor influencing market share.
Pricing Dynamics and Trends
Current Pricing Overview
As of 2023, the wholesale acquisition cost (WAC) for Repatha is approximately $5,850 per year for a 140 mg dose administered every two weeks. After discounts and rebates, the net price to payers and patients can vary significantly, often reducing the list price by 20-40%.
Historical Pricing Trends
Between 2015 and 2023, drug pricing for Repatha has remained relatively stable, with incremental price increases averaging 2-3% annually. Price reductions due to increased competition, policy pressure, and market saturation have been observed but have not significantly altered the baseline due to patent protections and high treatment efficacy.
Reimbursement and Price Negotiation Factors
Reimbursement strategies heavily influence actual transaction prices. Payers deploy utilization management tools, negotiated rebates, and tiered formularies to control costs. The introduction of value-based pricing models has aimed to align drug prices with clinical outcomes, potentially impacting future pricing.
Regulatory and Patent Landscape
Patent Exclusivity and Patent Expiry
Amgen holds patents protecting Repatha until approximately 2030. Patent expiry would open the market to biosimilars, likely exerting downward pressure on prices.
Regulatory Changes
Policy efforts to contain drug costs, such as increased transparency in rebate arrangements and potential importation pathways, could influence pricing strategies. The evolving regulatory landscape emphasizes value-based care, potentially impacting future drug prices.
Price Projection Analysis
Assumptions
- The patent exclusivity remains intact until 2030, maintaining limited biosimilar competition.
- Market demand sustains at approximately 70-80% of eligible patient populations, considering barriers and physician adoption rates.
- Payer negotiations and value-based pricing models lead to an average net price reduction of 2-4% annually post-2024.
- Introduction of biosimilars around 2030 could reduce prices by 30-50%, depending on market response.
Forecast (2023-2030)
| Year | Estimated Brand Price (USD) | Notes |
|---|---|---|
| 2023 | $5,850 | Current list price |
| 2024 | $5,733 - $5,721 | Minor decrease via negotiation efforts |
| 2025 | $5,615 - $5,609 | Stable, with slight downward pressure |
| 2026 | $5,502 - $5,492 | Potential early value-based adjustments |
| 2027 | $5,392 - $5,384 | Continued stabilization |
| 2028 | $5,285 - $5,278 | Approaching patent expiry considerations |
| 2029 | $5,180 - $5,174 | Increased pressure from biosimilar development |
| 2030 | $4,700 - $3,500 (biosimilar entry) | Biosimilar competition drives significant reduction |
Note: The notable decrease post-2030 aligns with patent expiry, increased biosimilar market entries, and competitive pricing.
Implications for Stakeholders
Manufacturers
Amgen's revenue depends on maintaining market share and negotiating favorable pricing within the evolving payer landscape. Long-term viability relies on innovation pipelines and cost-effective manufacturing.
Payers and Providers
Cost-containment strategies will continue to pressure prices downward, incentivizing adoption of biosimilars and alternative therapies. Value-based agreements will further influence drug utilization.
Investors
Price stability is expected until 2030, with substantial valuation risks and opportunities tied to patent life cycles and biosimilar market development.
Patients
Reimbursement policies, copay assistance programs, and biosimilar competition impact out-of-pocket costs, influencing adherence and treatment outcomes.
Key Takeaways
- Market Demand: The global hypercholesterolemia treatment market is growing, with PCSK9 inhibitors like Repatha occupying a significant niche, especially among high-risk populations.
- Pricing Trajectory: Repatha's price is likely to stabilize around current levels until patent expiration, with expectation of slight annual decreases driven by negotiations and value-based pricing, eventually leading to substantial reductions post-2030 due to biosimilar competition.
- Competitive Landscape: Patent protection shields Repatha from biosimilar competition until approximately 2030, after which prices are expected to decline sharply. Core competitors and biosimilar entrants will influence long-term pricing.
- Regulatory Environment: Policy trends favor cost containment and value-based pricing, potentially accelerating price reductions and market share shifts.
- Investment Outlook: Stable revenue projected until at least 2030, with significant upside or risk contingent on patent challenges, biosimilar development, and regulatory reforms.
FAQs
1. When can biosimilars for Repatha (Evolucumab) be expected to enter the market?
Biosimilar development typically aligns with patent expiration, projected around 2030 for Repatha. The regulatory approval process and market readiness may bring biosimilars to market shortly thereafter.
2. How do reimbursement policies influence the effective price of Repatha?
Reimbursement negotiations, rebates, and formulary placements determine the net price to payers and patients. Value-based agreements and utilization management further affect actual transaction prices.
3. What factors could accelerate the price decline of Repatha before patent expiry?
Introduction of biosimilars, regulatory pressure for cost containment, increased adoption of generics, and policy reforms aimed at lowering drug costs could precipitate earlier price reductions.
4. How does clinical efficacy impact pricing strategies for PCSK9 inhibitors?
Higher clinical efficacy and safety profiles justify premium pricing. Conversely, comparable efficacy among competitors can lead to price competition. Real-world evidence of improved outcomes can support favorable pricing negotiations.
5. What are the strategic implications for manufacturers aiming to extend Repatha’s market exclusivity?
Investing in additional indications, improving formulations (e.g., longer-acting versions), and demonstrating cost-effectiveness can help sustain market dominance until biosimilars emerge.
References
[1] Industry reports on hypercholesterolemia market size (2022).
[2] FDA approval documentation for Evolucumab (Repatha).
[3] Amgen corporate financial disclosures and patent filings.
[4] Market research on biosimilar entry timelines and development costs.
[5] Payer policy analyses and drug pricing studies.
This comprehensive analysis aims to inform strategic decision-making through precise pricing forecasts and market insights, anchored in current industry data and regulatory trends.
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