Effect of the Motilin Receptor Agonist, Erythromycin, on Hunger and Food Intake; Study of Role of Cholinergic Pathways
Universitaire Ziekenhuizen Leuven
In this study, the investigators will evaluate if the food intake associated with the
infusion of erythromycin is caused by the phase 3 contractions or by another yet unknown
effect of erythromycin. To obtain this the investigators will use atropine, a muscarinic
receptor antagonist, to inhibit the formation of contractions induced by a low dose of
ANTERO-4: VIPUN Gastric Monitoring System in an Erythromycin Model
Not yet recruiting
Prof Dr Jan Tack
It has been demonstrated that the VIPUN Gastric Monitoring System (GMS) can discriminate
healthy physiological and pharmacologically-inhibited gastric motility, using a codeine-model
in healthy adults (S60320 / AFMPS80M0687).
Erythromycin is a gastroprokinetic agent, known to stimulate gastric contractility. A single
dose of 200 mg erythromycin has been shown to induce a prolonged period of enhanced phasic
The primary aim of this investigation is to validate the ability of the VIPUN GMS to
discriminate between normal and pharmacologically-enhanced fasting gastric motility in
The performance of the VIPUN GMS can be enhanced by data-driven optimization of the VIPUN
Motility Algorithm, used to quantify gastric motility.
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