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Last Updated: August 9, 2020

DrugPatentWatch Database Preview

CLINICAL TRIALS PROFILE FOR AVAPRITINIB

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All Clinical Trials for avapritinib

Trial ID Title Status Sponsor Phase Start Date Summary
NCT03465722 (VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST Recruiting Blueprint Medicines Corporation Phase 3 2018-03-26 This is an open-label, randomized, Phase 3 study in patients with locally advanced unresectable or metastatic GIST (advanced GIST) of avapritinib (also known as BLU-285) versus regorafenib in patients previously treated with imatinib and 1 or 2 other TKIs.
NCT03580655 (PATHFINDER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, in Patients With Advanced Systemic Mastocytosis Recruiting Blueprint Medicines Corporation Phase 2 2018-10-01 This is an open-label, single arm, Phase 2 study evaluating the efficacy and safety of avapritinib (BLU-285) in patients with advanced systemic mastocytosis (AdvSM), including patients with aggressive SM (ASM), SM with associated hematologic neoplasm (SM-AHN), and mast cell leukemia (MCL)
NCT03731260 (PIONEER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, Versus Placebo in Patients With Indolent and Smoldering Systemic Mastocytosis Not yet recruiting Blueprint Medicines Corporation Phase 2 2019-01-01 This is a Phase 2, randomized, double-blind, placebo-controlled study comparing the efficacy and safety of avapritinib + best supportive care (BSC) with placebo + BSC in patients with indolent systemic mastocytosis (ISM) and smoldering systemic mastocytosis (SSM) whose symptoms are not adequately controlled by BSC. The study will be conducted in 3 parts. All patients will receive treatment with avapritinib during Part 3 including those rolling over from the placebo group.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for avapritinib

Condition Name

Condition Name for avapritinib
Intervention Trials
Indolent Systemic Mastocytosis 1
GIST 1
Gastrointestinal Stromal Tumors 1
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Condition MeSH

Condition MeSH for avapritinib
Intervention Trials
Mastocytosis 2
Gastrointestinal Stromal Tumors 2
Mastocytosis, Systemic 2
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Clinical Trial Locations for avapritinib

Trials by Country

Trials by Country for avapritinib
Location Trials
United States 13
France 1
United Kingdom 1
China 1
Australia 1
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Trials by US State

Trials by US State for avapritinib
Location Trials
California 1
Washington 1
Texas 1
Tennessee 1
Pennsylvania 1
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Clinical Trial Progress for avapritinib

Clinical Trial Phase

Clinical Trial Phase for avapritinib
Clinical Trial Phase Trials
Phase 3 1
Phase 2 2
Phase 1/Phase 2 1
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Clinical Trial Status

Clinical Trial Status for avapritinib
Clinical Trial Phase Trials
Recruiting 3
Not yet recruiting 1
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Clinical Trial Sponsors for avapritinib

Sponsor Name

Sponsor Name for avapritinib
Sponsor Trials
Blueprint Medicines Corporation 4
CStone Pharmaceuticals 1
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Sponsor Type

Sponsor Type for avapritinib
Sponsor Trials
Industry 5
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