Treatment of Agitation/Psychosis in Dementia/Parkinsonism (TAP/DAP)
National Institute on Aging (NIA)
The primary aim of this study is to determine the safety and efficacy of quetiapine
(Seroquel) for the treatment of psychosis and/or agitation in patients with primary dementia
complicated by coexistent parkinsonism, or patients with Parkinson's disease with dementia
[PDD] who have episodes of agitation or psychosis. The secondary aim is to determine the
safety and tolerability, particularly the influence on parkinsonism, of quetiapine when used
to treat psychosis and/or agitation in patients with dementia complicated by coexistent
This study will evaluate the effectiveness of switching medications in decreasing
schizophrenia symptoms in individuals who are currently taking an antipsychotic medication
for the treatment of schizophrenia.
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