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Generated: June 26, 2019

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CLINICAL TRIALS PROFILE FOR RIOCIGUAT

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Clinical Trials for Riociguat

Trial ID Title Status Sponsor Phase Summary
NCT00855660 Effect of Riociguat on Bone Metabolism Completed Bayer Phase 1 Investigation of the effect of Riociguat, administered as 2.5 mg IR-tablets TID over 14 days, on bone metabolism.
NCT01014247 Influence of Moxifloxacin on QTc Interval in Healthy Subjects for Positive Control Validation Completed Bayer Phase 1 The aim of this study is to investigate the effect of moxifloxacin on the QT interval in order to gain information on the validity of results that will be collected during another clinical study testing riociguat in patients with pulmonary arterial hypertension (PATENT-1 study).
NCT01065051 Hemodynamic and Echocardiographic Assessment of Riociguat Effects on Myocardial Wall Contractility and Relaxation Kinetics Terminated Bayer Phase 2 The aim of this study is to assess whether oral Riociguat affects the left ventricular contractility and relaxation in patients with pulmonary hypertension associated with left ventricular systolic dysfunction
NCT01065454 A Study to Test the Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Left Ventricular Systolic Dysfunction Active, not recruiting Bayer Phase 2 The aim of this study is to assess whether increasing oral doses of Riociguat are safe and improve the well-being, symptoms and outcome in patients with pulmonary hypertension associated with left ventricular systolic dysfunction
NCT01165931 Coronary Vasomotor Response After Riociguat Exposure Withdrawn Bayer Phase 2 The aim of the study is to assess the effects of intracoronary Riociguat on coronary blood flow in subjects with coronary artery disease and to compare this effect with the intracoronary nitroglycerin, a coronary vasodilator widly used to treat patients with coronary artery disease.
NCT01172756 A Study to Test the Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Left Ventricular Diastolic Dysfunction Terminated Bayer Phase 2 The aim of this study is to assess whether single oral doses of Riociguat safely improve the cardiovascular function in patients with pulmonary hypertension associated with left ventricular diastolic dysfunction
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Riociguat

Condition Name

Condition Name for Riociguat
Intervention Trials
Hypertension, Pulmonary 12
Ventricular Dysfunction, Left 3
Chronic Thromboembolic Pulmonary Hypertension 3
Pulmonary Hypertension 2
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Condition MeSH

Condition MeSH for Riociguat
Intervention Trials
Hypertension, Pulmonary 19
Hypertension 18
Familial Primary Pulmonary Hypertension 5
Ventricular Dysfunction, Left 3
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Clinical Trial Locations for Riociguat

Trials by Country

Trials by Country for Riociguat
Location Trials
United States 104
Germany 60
Japan 34
Italy 23
United Kingdom 22
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Trials by US State

Trials by US State for Riociguat
Location Trials
Massachusetts 8
Ohio 7
New York 7
Colorado 7
California 7
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Clinical Trial Progress for Riociguat

Clinical Trial Phase

Clinical Trial Phase for Riociguat
Clinical Trial Phase Trials
Phase 4 5
Phase 3 2
Phase 2 14
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Clinical Trial Status

Clinical Trial Status for Riociguat
Clinical Trial Phase Trials
Recruiting 13
Completed 9
Not yet recruiting 3
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Clinical Trial Sponsors for Riociguat

Sponsor Name

Sponsor Name for Riociguat
Sponsor Trials
Bayer 27
Merck Sharp & Dohme Corp. 2
Medical University of Vienna 2
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Sponsor Type

Sponsor Type for Riociguat
Sponsor Trials
Industry 29
Other 10
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