Influence of Moxifloxacin on QTc Interval in Healthy Subjects for Positive Control Validation
Completed
Bayer
Phase 1
2009-11-01
The aim of this study is to investigate the effect of moxifloxacin on the QT interval in
order to gain information on the validity of results that will be collected during another
clinical study testing riociguat in patients with pulmonary arterial hypertension (PATENT-1
study).
Hemodynamic and Echocardiographic Assessment of Riociguat Effects on Myocardial Wall Contractility and Relaxation Kinetics
Terminated
Bayer
Phase 2
2010-11-01
The aim of this study is to assess whether oral Riociguat affects the left ventricular
contractility and relaxation in patients with pulmonary hypertension associated with left
ventricular systolic dysfunction
A Study to Test the Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Left Ventricular Systolic Dysfunction
Active, not recruiting
Bayer
Phase 2
2010-04-14
The aim of this study is to assess whether increasing oral doses of Riociguat are safe and
improve the well-being, symptoms and outcome in patients with pulmonary hypertension
associated with left ventricular systolic dysfunction
Coronary Vasomotor Response After Riociguat Exposure
Withdrawn
Bayer
Phase 2
2012-05-01
The aim of the study is to assess the effects of intracoronary Riociguat on coronary blood
flow in subjects with coronary artery disease and to compare this effect with the
intracoronary nitroglycerin, a coronary vasodilator widly used to treat patients with
coronary artery disease.
A Study to Test the Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Left Ventricular Diastolic Dysfunction
Terminated
Bayer
Phase 2
2010-07-01
The aim of this study is to assess whether single oral doses of Riociguat safely improve the
cardiovascular function in patients with pulmonary hypertension associated with left
ventricular diastolic dysfunction
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