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Last Updated: February 3, 2023

CLINICAL TRIALS PROFILE FOR MEKTOVI


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All Clinical Trials for Mektovi

Trial ID Title Status Sponsor Phase Start Date Summary
NCT02465060 ↗ Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial) Recruiting National Cancer Institute (NCI) Phase 2 2015-08-12 This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Patients with genetic abnormalities (such as mutations, amplifications, or translocations) may benefit more from treatment which targets their tumor's particular genetic abnormality. Identifying these genetic abnormalities first may help doctors plan better treatment for patients with solid tumors, lymphomas, or multiple myeloma.
NCT02902042 ↗ Encorafenib + Binimetinib + Pembrolizumab in Patients With Unresectable or Metastatic BRAF V600 Mutant Melanoma Completed Prof. Dr. med. Dirk Schadendorf Phase 1/Phase 2 2018-04-24 This study will investigate the influence of maintenance therapy on progression-free survival (PFS) and overall survival (OS) after combination therapy with BRAF/MEK (MAP-ERK kinase) inhibitors and PD-1 antibody pembrolizumab. In the safety phase I part the optimal dose of pembrolizumab in combination with BRAF inhibitor and MEK inhibitor and the safety of this three-drugs-combination regime will be determined. In the randomized part 2 different maintenance therapies will be tested for toxicity and efficacy. Patients with disease control after 6 months of triple therapy will be randomized to receive 2 different maintenance therapies further on, either continuation of triple therapy or administration of pembrolizumab alone.
NCT02910700 ↗ Nivolumab With Trametinib and Dabrafenib, or Encorafenib and Binimetinib in Treating Patients With BRAF Mutated Metastatic or Unresectable Stage III-IV Melanoma Recruiting Bristol-Myers Squibb Phase 2 2016-12-09 This phase II trial studies the side effects and how well nivolumab with trametinib and dabrafenib, or encorafenib and binimetinib work in treating patients with BRAF-mutated stage III-IV melanoma that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable). Immunotherapy with monoclonal antibodies, such as nivolumab, may induce changes in the body's immune system and may interfere with the ability of tumor cells to grow and spread. Trametinib, dabrafenib, encorafenib, and binimetinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known if nivolumab with trametinib and dabrafenib, or encorafenib and binimetinib may work better in treating patients with BRAF-mutated melanoma.
NCT02910700 ↗ Nivolumab With Trametinib and Dabrafenib, or Encorafenib and Binimetinib in Treating Patients With BRAF Mutated Metastatic or Unresectable Stage III-IV Melanoma Recruiting National Cancer Institute (NCI) Phase 2 2016-12-09 This phase II trial studies the side effects and how well nivolumab with trametinib and dabrafenib, or encorafenib and binimetinib work in treating patients with BRAF-mutated stage III-IV melanoma that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable). Immunotherapy with monoclonal antibodies, such as nivolumab, may induce changes in the body's immune system and may interfere with the ability of tumor cells to grow and spread. Trametinib, dabrafenib, encorafenib, and binimetinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known if nivolumab with trametinib and dabrafenib, or encorafenib and binimetinib may work better in treating patients with BRAF-mutated melanoma.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Mektovi

Condition Name

Condition Name for Mektovi
Intervention Trials
Metastatic Melanoma 6
Melanoma 5
Advanced Malignant Solid Neoplasm 4
Malignant Solid Neoplasm 3
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Condition MeSH

Condition MeSH for Mektovi
Intervention Trials
Melanoma 16
Neoplasms 8
Carcinoma 7
Skin Neoplasms 6
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Clinical Trial Locations for Mektovi

Trials by Country

Trials by Country for Mektovi
Location Trials
United States 149
Germany 10
Spain 8
Australia 4
Canada 3
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Trials by US State

Trials by US State for Mektovi
Location Trials
Texas 11
California 10
Massachusetts 8
Florida 8
Pennsylvania 6
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Clinical Trial Progress for Mektovi

Clinical Trial Phase

Clinical Trial Phase for Mektovi
Clinical Trial Phase Trials
Phase 3 2
Phase 2 18
Phase 1/Phase 2 7
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Clinical Trial Status

Clinical Trial Status for Mektovi
Clinical Trial Phase Trials
Recruiting 16
Not yet recruiting 12
Active, not recruiting 4
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Clinical Trial Sponsors for Mektovi

Sponsor Name

Sponsor Name for Mektovi
Sponsor Trials
National Cancer Institute (NCI) 16
Pierre Fabre Medicament 4
Array BioPharma 4
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Sponsor Type

Sponsor Type for Mektovi
Sponsor Trials
Other 32
Industry 26
NIH 16
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