Tailored Treatment of H. Pylori Infection Based Polymorphisms of CYP2C19 and 23S rRNA of H. Pylori
Unknown status
Yokoyama Foundation for Clinical Pharmacology
Phase 3
2003-04-01
The eradication rate of the standard H. pylori eradication therapy (such as the triple
therapy with a proton pump inhibitor [PPI], amoxicillin and clarithromycin) depends on
bacterial susceptibility to clarithromycin and genotypes of CYP2C19 in patients. The
investigators intend to investigate whether the tailored therapy based on the two
above-mentioned factors increases the cure rate of the initial eradication therapy.
Tailored Treatment of H. Pylori Infection Based Polymorphisms of CYP2C19 and 23S rRNA of H. Pylori
Unknown status
Hamamatsu University
Phase 3
2003-04-01
The eradication rate of the standard H. pylori eradication therapy (such as the triple
therapy with a proton pump inhibitor [PPI], amoxicillin and clarithromycin) depends on
bacterial susceptibility to clarithromycin and genotypes of CYP2C19 in patients. The
investigators intend to investigate whether the tailored therapy based on the two
above-mentioned factors increases the cure rate of the initial eradication therapy.
The ability to metabolize drugs varies greatly among individuals. Major fraction of this
variability lies in genetic polymorphisms of genes encoding for enzymes responsible for both
phase I and phase II reactions.
The purpose of this study ws to evaluate the phenotypic activity and the frequency of genetic
polymorphisms in different phase II and phase I enzymes among various populations residing in
Israel.
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