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Generated: December 10, 2018

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CLINICAL TRIALS PROFILE FOR LOPINAVIR AND RITONAVIR

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Clinical Trials for Lopinavir And Ritonavir

Trial ID Title Status Sponsor Phase Summary
NCT00004578 ABT-378/Ritonavir in Combination With Reverse Transcriptase Inhibitors in Antiretroviral Naïve HIV-Infected Subjects Completed Abbott Phase 1/Phase 2 To assess the safety, tolerability and antiviral activity of lopinavir/ritonavir when administered orally in antiretroviral-HIV-1 infected subjects.
NCT00006144 A Study of HIV-Disease Development in Aging Completed National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 The purpose of this study is to better understand the relationship between age and HIV disease progression. This study will explore the possible relationship between age and HIV disease progression. Older age is an important risk factor for faster disease development, but older people may respond better to combination drug therapy. This relationship needs to be understood better.
NCT00014937 Simplified Drug Regimens for HIV Patients in ACTG 388 or Patients Who Responded to A First Potent Combination Regimen Completed National Institute of Allergy and Infectious Diseases (NIAID) N/A ACTG 388 was a clinical trial that compared three- and four-drug anti-HIV drug regimens and demonstrated the effectiveness of a three-drug regimen. This study will compare the ability of two different three-drug anti-HIV drug regimens to reduce levels of HIV in the blood. The study will also evaluate whether patients discontinue the regimens because of drug side effects.
NCT00017992 Emtricitabine Given Once A Day With Other Anti-HIV Drugs in Children With HIV Unknown status Triangle Pharmaceuticals Phase 2 The purpose of this study is to see if emtricitabine is safe in children infected with HIV and to determine the best dose.
NCT00023218 Effect of a Change in HIV Therapy on Liver Steatosis, Inflammation, and Fibrosis Withdrawn National Institute of Allergy and Infectious Diseases (NIAID) N/A The purpose of this study is to look at how 2 different anti-HIV drug treatments affect the liver. The use of anti-HIV drugs like the nucleoside reverse transcriptase inhibitors (NRTIs) may be linked to liver problems like fatty changes, scarring, abnormal liver function tests (LFTs), and lactic acidemia (an increase in lactic acid in the blood). Increased liver enzymes may mean liver damage. The way that the liver changes in people with abnormal LFTs and lactic acidemia is not completely understood.
NCT00025727 Comparison of Two Dosing Regimens of GW433908/Ritonavir Versus Lopinavir/Ritonavir for 48 Weeks in HIV Patients Who Have Taken Protease Inhibitors and Experienced Virological Failure Unknown status GlaxoSmithKline Phase 3 The purpose of this study is to test 2 different dosing regimens of GW433908/ritonavir (RTV) versus lopinavir (LPV)/RTV when each is given with 2 active reverse transcriptase inhibitors (RTIs), in patients who have taken anti-HIV drugs without success.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Lopinavir And Ritonavir

Condition Name

Condition Name for Lopinavir And Ritonavir
Intervention Trials
HIV Infections 134
HIV 33
HIV Infection 30
Tuberculosis 12
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Condition MeSH

Condition MeSH for Lopinavir And Ritonavir
Intervention Trials
HIV Infections 187
Acquired Immunodeficiency Syndrome 40
Immunologic Deficiency Syndromes 25
Infection 23
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Clinical Trial Locations for Lopinavir And Ritonavir

Trials by Country

Trials by Country for Lopinavir And Ritonavir
Location Trials
United States 707
Spain 75
Thailand 61
Canada 54
South Africa 47
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Trials by US State

Trials by US State for Lopinavir And Ritonavir
Location Trials
California 57
New York 50
Florida 39
Texas 38
Illinois 37
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Clinical Trial Progress for Lopinavir And Ritonavir

Clinical Trial Phase

Clinical Trial Phase for Lopinavir And Ritonavir
Clinical Trial Phase Trials
Phase 4 80
Phase 3 54
Phase 2/Phase 3 10
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Clinical Trial Status

Clinical Trial Status for Lopinavir And Ritonavir
Clinical Trial Phase Trials
Completed 182
Terminated 24
Unknown status 21
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Clinical Trial Sponsors for Lopinavir And Ritonavir

Sponsor Name

Sponsor Name for Lopinavir And Ritonavir
Sponsor Trials
Abbott 55
National Institute of Allergy and Infectious Diseases (NIAID) 45
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 16
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Sponsor Type

Sponsor Type for Lopinavir And Ritonavir
Sponsor Trials
Other 271
Industry 134
NIH 72
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Serving hundreds of leading biopharmaceutical companies globally:

Healthtrust
Covington
Federal Trade Commission
Dow
US Army
US Department of Justice
Teva
Julphar
Chinese Patent Office

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