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Last Updated: May 16, 2021

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CLINICAL TRIALS PROFILE FOR ISONIAZID; PYRAZINAMIDE; RIFAMPIN

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All Clinical Trials for Isoniazid; Pyrazinamide; Rifampin

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00000636 Prophylaxis Against Tuberculosis (TB) in Patients With Human Immunodeficiency Virus (HIV) Infection and Confirmed Latent Tuberculous Infection Completed National Institute of Allergy and Infectious Diseases (NIAID) N/A 1969-12-31 To evaluate and compare the effectiveness of a 2-month regimen of rifampin and pyrazinamide versus a 1-year course of isoniazid (INH) to prevent the development of tuberculosis in patients who are coinfected with HIV and latent Mycobacterium tuberculosis (MTb). Current guidelines recommend 6 to 12 months of treatment with INH for purified protein derivative (PPD)-positive individuals. Problems with this treatment include compliance, adverse reaction, and the possibility of not preventing disease due to INH-resistant organisms. Studies suggest that two or three months of rifampin and pyrazinamide may be more effective than longer courses of INH. A two-month prevention course should help to increase compliance. In addition, the use of two drugs (rifampin and pyrazinamide) may help overcome problems with drug resistance.
NCT00000638 Preventive Treatment Against Tuberculosis (TB) in Patients With Human Immunodeficiency Virus (HIV) Infection and Confirmed Latent Tuberculous Infection Completed Hoechst Marion Roussel N/A 1969-12-31 To evaluate and compare the safety and effectiveness of a one-year course of isoniazid (INH) versus a two-month course of rifampin plus pyrazinamide for the prevention of reactivation tuberculosis in individuals infected with both HIV and latent (inactive) Mycobacterium tuberculosis. Current guidelines from the American Thoracic Society and the Centers for Disease Control recommend 6 to 12 months of INH for PPD (purified protein derivative)-positive individuals. Although the effectiveness of this treatment is not known for HIV-infected individuals, several studies using INH to prevent tuberculosis in presumably normal hosts have shown 60 to 80 percent effectiveness. Problems with this treatment include compliance, adverse reaction, and the possibility of not preventing disease due to tuberculosis organisms being resistant to INH. A two-month preventive treatment plan should help in increasing compliance. In addition, the use of two drugs (rifampin / pyrazinamide) may help overcome problems with drug resistance. If this study shows equal or greater effectiveness of the two-month rifampin / pyrazinamide treatment, it could alter the approach to tuberculosis prevention for both HIV-positive and HIV-negative individuals.
NCT00000638 Preventive Treatment Against Tuberculosis (TB) in Patients With Human Immunodeficiency Virus (HIV) Infection and Confirmed Latent Tuberculous Infection Completed Lederle Laboratories N/A 1969-12-31 To evaluate and compare the safety and effectiveness of a one-year course of isoniazid (INH) versus a two-month course of rifampin plus pyrazinamide for the prevention of reactivation tuberculosis in individuals infected with both HIV and latent (inactive) Mycobacterium tuberculosis. Current guidelines from the American Thoracic Society and the Centers for Disease Control recommend 6 to 12 months of INH for PPD (purified protein derivative)-positive individuals. Although the effectiveness of this treatment is not known for HIV-infected individuals, several studies using INH to prevent tuberculosis in presumably normal hosts have shown 60 to 80 percent effectiveness. Problems with this treatment include compliance, adverse reaction, and the possibility of not preventing disease due to tuberculosis organisms being resistant to INH. A two-month preventive treatment plan should help in increasing compliance. In addition, the use of two drugs (rifampin / pyrazinamide) may help overcome problems with drug resistance. If this study shows equal or greater effectiveness of the two-month rifampin / pyrazinamide treatment, it could alter the approach to tuberculosis prevention for both HIV-positive and HIV-negative individuals.
NCT00000638 Preventive Treatment Against Tuberculosis (TB) in Patients With Human Immunodeficiency Virus (HIV) Infection and Confirmed Latent Tuberculous Infection Completed National Institute of Allergy and Infectious Diseases (NIAID) N/A 1969-12-31 To evaluate and compare the safety and effectiveness of a one-year course of isoniazid (INH) versus a two-month course of rifampin plus pyrazinamide for the prevention of reactivation tuberculosis in individuals infected with both HIV and latent (inactive) Mycobacterium tuberculosis. Current guidelines from the American Thoracic Society and the Centers for Disease Control recommend 6 to 12 months of INH for PPD (purified protein derivative)-positive individuals. Although the effectiveness of this treatment is not known for HIV-infected individuals, several studies using INH to prevent tuberculosis in presumably normal hosts have shown 60 to 80 percent effectiveness. Problems with this treatment include compliance, adverse reaction, and the possibility of not preventing disease due to tuberculosis organisms being resistant to INH. A two-month preventive treatment plan should help in increasing compliance. In addition, the use of two drugs (rifampin / pyrazinamide) may help overcome problems with drug resistance. If this study shows equal or greater effectiveness of the two-month rifampin / pyrazinamide treatment, it could alter the approach to tuberculosis prevention for both HIV-positive and HIV-negative individuals.
NCT00000950 Metabolism of Antituberculosis Drugs in HIV-Infected Persons With Tuberculosis Completed National Institute of Allergy and Infectious Diseases (NIAID) N/A 1969-12-31 The purpose of this study is to determine if a relationship exists between the level of antituberculosis drugs (isoniazid, rifampin, ethambutol, and pyrazinamide) in the blood and the outcome of HIV-positive patients with tuberculosis. This study also evaluates how these drugs are absorbed and metabolized in the body.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Isoniazid; Pyrazinamide; Rifampin

Condition Name

Condition Name for Isoniazid; Pyrazinamide; Rifampin
Intervention Trials
Tuberculosis 20
HIV Infections 7
Tuberculosis, Pulmonary 5
Pulmonary Tuberculosis 3
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Condition MeSH

Condition MeSH for Isoniazid; Pyrazinamide; Rifampin
Intervention Trials
Tuberculosis 34
Tuberculosis, Pulmonary 11
HIV Infections 7
Infection 6
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Clinical Trial Locations for Isoniazid; Pyrazinamide; Rifampin

Trials by Country

Trials by Country for Isoniazid; Pyrazinamide; Rifampin
Location Trials
United States 115
China 19
Canada 15
South Africa 14
Brazil 10
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Trials by US State

Trials by US State for Isoniazid; Pyrazinamide; Rifampin
Location Trials
California 10
New York 9
Texas 8
Maryland 8
New Jersey 7
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Clinical Trial Progress for Isoniazid; Pyrazinamide; Rifampin

Clinical Trial Phase

Clinical Trial Phase for Isoniazid; Pyrazinamide; Rifampin
Clinical Trial Phase Trials
Phase 4 7
Phase 3 8
Phase 2 12
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Clinical Trial Status

Clinical Trial Status for Isoniazid; Pyrazinamide; Rifampin
Clinical Trial Phase Trials
Completed 17
Not yet recruiting 6
Recruiting 6
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Clinical Trial Sponsors for Isoniazid; Pyrazinamide; Rifampin

Sponsor Name

Sponsor Name for Isoniazid; Pyrazinamide; Rifampin
Sponsor Trials
Centers for Disease Control and Prevention 7
National Institute of Allergy and Infectious Diseases (NIAID) 7
Johns Hopkins University 4
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Sponsor Type

Sponsor Type for Isoniazid; Pyrazinamide; Rifampin
Sponsor Trials
Other 97
U.S. Fed 9
NIH 8
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Moodys
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McKinsey
Harvard Business School

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