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CLINICAL TRIALS PROFILE FOR HYDROMORPHONE HYDROCHLORIDE

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Clinical Trials for Hydromorphone Hydrochloride

Trial ID	Title	Status	Sponsor	Phase	Summary
NCT00003115	Epidural Hydromorphone Compared With Hydromorphone Infusion in Treating Patients With Prostate Cancer Undergoing Radical Prostatectomy	Completed	Roswell Park Cancer Institute	Phase 3	RATIONALE: Giving hydromorphone in different ways may relieve the pain associated with cancer surgery. PURPOSE: Randomized double-blinded phase III trial to compare the effectiveness of epidural hydromorphone with hydromorphone infusion in patients with prostate cancer undergoing radical prostatectomy.
NCT00125801	The Pain Pen for Breakthrough Cancer Pain	Terminated	Erasmus Medical Center	Phase 3	The purpose of this study is to see whether injection of hydromorphone through a subcutaneous injection device is more effective in treating breakthrough cancer pain than oral morphine.
NCT00134875	Assessing Abuse Potential of Parenteral Buprenorphine/Naloxone in Non-Dependent Opioid Abusers	Terminated	National Institute of Allergy and Infectious Diseases (NIAID)	N/A	Buprenorphine, a treatment for opioid dependence, can be mixed with another drug, naloxone, to limit abuse potential. Parenteral administration (intravenous or intramuscular injection) of buprenorphine/naloxone causes withdrawal symptoms in opioid dependent individuals. However, naloxone does not cause withdrawal symptoms in non-dependent opioid abusers. This study will investigate whether naloxone decreases the opioid agonist effect from injected buprenorphine, hence decreasing the abuse potential of buprenorphine/naloxone, in non-dependent opioid abusers.
NCT00134888	Blockade Efficacy of Buprenorphine/Naloxone For Opioid Dependence	Completed	National Institute on Drug Abuse (NIDA)	N/A	Buprenorphine, a treatment for opioid dependence, can be mixed with naloxone, to limit abuse potential. The purpose of this study is to examine the effectiveness of buprenorphine/naloxone that is given at less than daily intervals, in order to prevent withdrawal symptoms associated with stopping opioid abuse.
NCT00134914	Effects of Buprenorphine/Naloxone Administered in Different Ways For Treating Opioid Dependence	Completed	National Institute on Drug Abuse (NIDA)	N/A	Buprenorphine is a treatment for opioid dependence. Naloxone is given in addition to buprenorphine in order to limit the abuse potential that is commonly associated with buprenorphine. The purpose of this study is to examine the effects of buprenorphine/naloxone when given through different routes and at different doses.

Clinical Trial Conditions for Hydromorphone Hydrochloride

Condition Name

Condition Name for Hydromorphone Hydrochloride
Intervention	Trials
Pain	56
Postoperative Pain	17
Acute Pain	16
Pain, Postoperative	13

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Condition MeSH

Condition MeSH for Hydromorphone Hydrochloride
Intervention	Trials
Pain, Postoperative	40
Acute Pain	20
Chronic Pain	10
Opioid-Related Disorders	10

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Clinical Trial Locations for Hydromorphone Hydrochloride

Trials by Country

Trials by Country for Hydromorphone Hydrochloride
Location	Trials
United States	179
Canada	18
Germany	6
China	4
Austria	4

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Trials by US State

Trials by US State for Hydromorphone Hydrochloride
Location	Trials
New York	31
Illinois	16
Texas	13
Ohio	10
Massachusetts	9

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Clinical Trial Progress for Hydromorphone Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Hydromorphone Hydrochloride
Clinical Trial Phase	Trials
Phase 4	83
Phase 3	43
Phase 2/Phase 3	1

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Clinical Trial Status

Clinical Trial Status for Hydromorphone Hydrochloride
Clinical Trial Phase	Trials
Completed	92
Recruiting	46
Not yet recruiting	28

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Clinical Trial Sponsors for Hydromorphone Hydrochloride

Sponsor Name

Sponsor Name for Hydromorphone Hydrochloride
Sponsor	Trials
Montefiore Medical Center	16
Alza Corporation, DE, USA	14
National Institute on Drug Abuse (NIDA)	12

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Sponsor Type

Sponsor Type for Hydromorphone Hydrochloride
Sponsor	Trials
Other	183
Industry	69
NIH	15

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