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Last Updated: October 24, 2020

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CLINICAL TRIALS PROFILE FOR DORZOLAMIDE HYDROCHLORIDE

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All Clinical Trials for Dorzolamide Hydrochloride

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00108017 Comparison of the Effects of Two Glaucoma Drugs Over 24 Hours (0507A-137)(COMPLETED) Completed Merck Sharp & Dohme Corp. Phase 3 2005-04-01 This study is comparing 2 medications for glaucoma and how effective they are at controlling glaucoma over the course of an entire day.
NCT00140049 A 12week, Randomized, Evaluator-Masked, Parallel Group Comparing Evening Dosing Of Xalacom Vs Cosopt In Subj W/ Glaucoma Completed Pfizer Phase 4 2005-07-01 To demonstrate the statistical non inferiority of the combination of latanoprost and timolol given in the evening time once a day vs the combination of dorzamalide and timolol twice a day based on intraocular pressure measurements at 8 AM, 12 noon & 4 PM during a 12 week treatment.
NCT00152932 Ocular Blood Flow in Early Glaucoma Patients Before and After Treatment With Dorzolamide Unknown status Merck Frosst Canada Ltd. N/A 2005-05-01 Impaired ocular blood flow is an important risk factor in the pathogenesis of primary open angle glaucoma (POAG). A few studies suggest that topical dorzolamide 2% may increase optic nerve perfusion. The objectives of this study are to learn the effects of dorzolamide on the retinal and optic nerve blood flow of glaucoma patients. The present study is a prospective, randomized, double-masked, crossover design study of newly diagnosed or already treated patients with early glaucoma. The investigators will check ocular blood flow parameters using the Canon Laser Blood Flowmeter (CLBF), used to evaluate retinal arteriole blood flow, and the Heidelberg retinal flowmeter (HRF), which measures blood flow through capillary beds in the retina and optic nerve head. Any demonstrated improvements to retinal and optic nerve blood flow with dorzolamide, will mean that the drug may protect against ischaemic nerve and retinal damage. Any documented improvement in flow could lead to a major change in the management of glaucoma patients as well as other retinal ischemic diseases such as diabetic retinopathy and central retinal vein occlusion.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Dorzolamide Hydrochloride

Condition Name

Condition Name for Dorzolamide Hydrochloride
Intervention Trials
Ocular Hypertension 22
Glaucoma 21
Open-Angle Glaucoma 9
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Condition MeSH

Condition MeSH for Dorzolamide Hydrochloride
Intervention Trials
Glaucoma 36
Ocular Hypertension 23
Glaucoma, Open-Angle 20
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Clinical Trial Locations for Dorzolamide Hydrochloride

Trials by Country

Trials by Country for Dorzolamide Hydrochloride
Location Trials
United States 29
Greece 5
Italy 4
Mexico 3
Canada 3
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Trials by US State

Trials by US State for Dorzolamide Hydrochloride
Location Trials
Pennsylvania 5
Illinois 4
Florida 3
Massachusetts 2
Texas 2
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Clinical Trial Progress for Dorzolamide Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Dorzolamide Hydrochloride
Clinical Trial Phase Trials
Phase 4 21
Phase 3 10
Phase 2/Phase 3 2
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Clinical Trial Status

Clinical Trial Status for Dorzolamide Hydrochloride
Clinical Trial Phase Trials
Completed 34
Unknown status 7
Recruiting 6
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Clinical Trial Sponsors for Dorzolamide Hydrochloride

Sponsor Name

Sponsor Name for Dorzolamide Hydrochloride
Sponsor Trials
Merck Sharp & Dohme Corp. 6
Allergan 4
Laboratorios Sophia S.A de C.V. 4
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Sponsor Type

Sponsor Type for Dorzolamide Hydrochloride
Sponsor Trials
Other 38
Industry 25
NIH 2
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