CLINICAL TRIALS PROFILE FOR CALCIUM CHLORIDE; DEXTROSE; LACTIC ACID; MAGNESIUM CHLORIDE; POTASSIUM CHLORIDE; SODIUM BICARBONATE; SODIUM CHLORIDE
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All Clinical Trials for Calcium Chloride; Dextrose; Lactic Acid; Magnesium Chloride; Potassium Chloride; Sodium Bicarbonate; Sodium Chloride
| Trial ID | Title | Status | Sponsor | Phase | Start Date | Summary |
|---|---|---|---|---|---|---|
| NCT01377337 ↗ | Sodium Bicarbonate in Cardiopulmonary Resuscitation | Unknown status | Rambam Health Care Campus | Phase 4 | 2011-12-01 | Out-of-hospital cardiac arrests (OHCA) account for over 60% of deaths from coronary artery disease. The annual incidence of OHCA treated by Emergency Medical Systems (EMS) is 41-89 per 100,000 population. Outcome of OHCA and cardiopulmonary resuscitation (CPR) is very poor: Less than 1/3 of the victims regain spontaneous circulation (ROSC), 40-60% of those achieving ROSC suffer significant neurological disability due to brain hypoxia and only 1.7-6.4% are discharged from the hospital. In order to minimize hypoxia time, the primary goal of CPR is to achieve return of spontaneous circulation (ROSC) as fast as possible. Metabolic (lactic) acidosis develops rapidly during CA and is considered detrimental to CPR outcome. Sodium bicarbonate (SB), a generic, commonly used acid buffer, was subjected only to a single, small, prospective controlled trial that found a trend towards improved outcome in prolonged OHCA and CPR. Another study indicated that EMS's that used SB early and often during CPR had significantly higher ROSC rates and better long-term outcome compared with EMS's that used SB more seldom and administered it late in the course of CPR. Aim of the Study: To determine whether early administration of SB during OHCA and CPR improves short-term CPR outcome. |
| NCT04547296 ↗ | Sodium Bicarbonate Ringer's Solution for Preventing and Treating Hyperlactacidemia During Hepatectomy | Recruiting | Affiliated Hospital of Qinghai University | N/A | 2021-04-28 | A variety of reasons lead to a sharp increase in lactic acid levels in patients undergoing liver resection, while leading to hyperlactic acidemia, resulting in decreased cardiac output, elevated blood potassium, and response to catecholamines and insulin Damage, increased risk of kidney damage, poor recovery of liver function, decreased immune function, and prolonged hospital stay. Sodium bicarbonate Ringer injection does not contain lactic acid. HCO3- is metabolized by acid-base neutralization in body fluids, and 90% is CO2 The form is excreted from the body by breathing, and only 10% HCO3- is metabolized by the kidney, without the burden of liver metabolism. Physiological concentration of Cl- avoids perchloric acidosis and kidney damage; physiological concentration of Ca2+ and Mg2+ help maintain the body's electrolyte balance and reduce stress-related arrhythmia.The smooth development of this study will help refine the intraoperative fluid management strategy, improve the patient's intraoperative tissue perfusion, maintain the body's acid-base and electrolyte balance, reduce postoperative kidney damage, and improve the patient's quality of life. |
| NCT04547296 ↗ | Sodium Bicarbonate Ringer's Solution for Preventing and Treating Hyperlactacidemia During Hepatectomy | Recruiting | First Affiliated Hospital of Xinjiang Medical University | N/A | 2021-04-28 | A variety of reasons lead to a sharp increase in lactic acid levels in patients undergoing liver resection, while leading to hyperlactic acidemia, resulting in decreased cardiac output, elevated blood potassium, and response to catecholamines and insulin Damage, increased risk of kidney damage, poor recovery of liver function, decreased immune function, and prolonged hospital stay. Sodium bicarbonate Ringer injection does not contain lactic acid. HCO3- is metabolized by acid-base neutralization in body fluids, and 90% is CO2 The form is excreted from the body by breathing, and only 10% HCO3- is metabolized by the kidney, without the burden of liver metabolism. Physiological concentration of Cl- avoids perchloric acidosis and kidney damage; physiological concentration of Ca2+ and Mg2+ help maintain the body's electrolyte balance and reduce stress-related arrhythmia.The smooth development of this study will help refine the intraoperative fluid management strategy, improve the patient's intraoperative tissue perfusion, maintain the body's acid-base and electrolyte balance, reduce postoperative kidney damage, and improve the patient's quality of life. |
| NCT04547296 ↗ | Sodium Bicarbonate Ringer's Solution for Preventing and Treating Hyperlactacidemia During Hepatectomy | Recruiting | Henan Cancer Hospital | N/A | 2021-04-28 | A variety of reasons lead to a sharp increase in lactic acid levels in patients undergoing liver resection, while leading to hyperlactic acidemia, resulting in decreased cardiac output, elevated blood potassium, and response to catecholamines and insulin Damage, increased risk of kidney damage, poor recovery of liver function, decreased immune function, and prolonged hospital stay. Sodium bicarbonate Ringer injection does not contain lactic acid. HCO3- is metabolized by acid-base neutralization in body fluids, and 90% is CO2 The form is excreted from the body by breathing, and only 10% HCO3- is metabolized by the kidney, without the burden of liver metabolism. Physiological concentration of Cl- avoids perchloric acidosis and kidney damage; physiological concentration of Ca2+ and Mg2+ help maintain the body's electrolyte balance and reduce stress-related arrhythmia.The smooth development of this study will help refine the intraoperative fluid management strategy, improve the patient's intraoperative tissue perfusion, maintain the body's acid-base and electrolyte balance, reduce postoperative kidney damage, and improve the patient's quality of life. |
| >Trial ID | >Title | >Status | >Sponsor | >Phase | >Start Date | >Summary |
Clinical Trial Conditions for Calcium Chloride; Dextrose; Lactic Acid; Magnesium Chloride; Potassium Chloride; Sodium Bicarbonate; Sodium Chloride
Condition Name
| Condition Name for Calcium Chloride; Dextrose; Lactic Acid; Magnesium Chloride; Potassium Chloride; Sodium Bicarbonate; Sodium Chloride | |
| Intervention | Trials |
| Metabolic Acidosis | 1 |
| Ringer Bicarbonate | 1 |
| Safety | 1 |
| Shock | 1 |
| [disabled in preview] | 0 |
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Condition MeSH
| Condition MeSH for Calcium Chloride; Dextrose; Lactic Acid; Magnesium Chloride; Potassium Chloride; Sodium Bicarbonate; Sodium Chloride | |
| Intervention | Trials |
| Hyperlactatemia | 1 |
| Out-of-Hospital Cardiac Arrest | 1 |
| Heart Arrest | 1 |
| Death, Sudden, Cardiac | 1 |
| [disabled in preview] | 0 |
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Clinical Trial Locations for Calcium Chloride; Dextrose; Lactic Acid; Magnesium Chloride; Potassium Chloride; Sodium Bicarbonate; Sodium Chloride
Clinical Trial Progress for Calcium Chloride; Dextrose; Lactic Acid; Magnesium Chloride; Potassium Chloride; Sodium Bicarbonate; Sodium Chloride
Clinical Trial Phase
Clinical Trial Status
| Clinical Trial Status for Calcium Chloride; Dextrose; Lactic Acid; Magnesium Chloride; Potassium Chloride; Sodium Bicarbonate; Sodium Chloride | |
| Clinical Trial Phase | Trials |
| Not yet recruiting | 2 |
| Recruiting | 2 |
| Unknown status | 1 |
| [disabled in preview] | 0 |
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Clinical Trial Sponsors for Calcium Chloride; Dextrose; Lactic Acid; Magnesium Chloride; Potassium Chloride; Sodium Bicarbonate; Sodium Chloride
Sponsor Name
| Sponsor Name for Calcium Chloride; Dextrose; Lactic Acid; Magnesium Chloride; Potassium Chloride; Sodium Bicarbonate; Sodium Chloride | |
| Sponsor | Trials |
| LanZhou University | 1 |
| People's Hospital of Xinjiang Uygur Autonomous Region | 1 |
| Shaanxi Provincial People's Hospital | 1 |
| [disabled in preview] | 1 |
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