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Last Updated: March 29, 2024

CLINICAL TRIALS PROFILE FOR ANTIZOL


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All Clinical Trials for Antizol

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00346853 ↗ Phase 1 Pilot Study of 4-MP to Treat Stargardt Macular Dystrophy Completed University of Utah Phase 1 2005-11-01 The purpose of this study is to investigate whether taking 4-methylpyrazole (4-MP, fomepizole, Antizol™) inhibits dark adaptation of the eye. In other words, we are testing if 4-MP slows the processing of vitamin A derivatives in the eye. By slowing down these processes, individuals with Stargardt disease may have better chances of saving their remaining vision. 4-MP has been shown to slow dark adaptation in animals, and is FDA approved for human use to treat individuals with methanol or ethylene glycol (antifreeze) poisoning by shutting down the body's ability to process alcohols. This medication has an excellent safety profile and has been reported to have no short-term or long-term side effects, as long as patients refrain from any alcohol while the medication is in the body. A single dose of 4-MP remains in the body for about 12 hours, and therefore, it may inhibit dark adaptation of your eyes for up to 12 hours. Studying the effects of 4-MP may lead to effective medical treatment to save Stargardt patients' vision, and may also have similar effects in other macular degenerative diseases.
NCT00661141 ↗ Phase IIa Study of Fomepizole for Acetaldehyde Toxicity After Ethanol Exposure in Subjects With Altered Ethanol Metabolism Completed Ted Daley, President Phase 2 2008-04-01 This trial will evaluate if fomepizole (4-methylpyrazole) can treat symptoms associated with alcohol intolerance due to aldehyde dehydrogenase 2 (ALDH2) deficiency, an inherited metabolic disorder. These symptoms include flushing, nausea, headache, shortness of breath and dizziness, resulting from exposure to acetaldehyde, the primary metabolite of ethanol. Long-term, serious health risks have been associated with repeated exposure to acetaldehyde, a carcinogen, among ALDH2-deficient individuals.
NCT00661141 ↗ Phase IIa Study of Fomepizole for Acetaldehyde Toxicity After Ethanol Exposure in Subjects With Altered Ethanol Metabolism Completed Horizon Pharma USA, Inc. Phase 2 2008-04-01 This trial will evaluate if fomepizole (4-methylpyrazole) can treat symptoms associated with alcohol intolerance due to aldehyde dehydrogenase 2 (ALDH2) deficiency, an inherited metabolic disorder. These symptoms include flushing, nausea, headache, shortness of breath and dizziness, resulting from exposure to acetaldehyde, the primary metabolite of ethanol. Long-term, serious health risks have been associated with repeated exposure to acetaldehyde, a carcinogen, among ALDH2-deficient individuals.
NCT00661141 ↗ Phase IIa Study of Fomepizole for Acetaldehyde Toxicity After Ethanol Exposure in Subjects With Altered Ethanol Metabolism Completed Raptor Pharmaceuticals Inc. Phase 2 2008-04-01 This trial will evaluate if fomepizole (4-methylpyrazole) can treat symptoms associated with alcohol intolerance due to aldehyde dehydrogenase 2 (ALDH2) deficiency, an inherited metabolic disorder. These symptoms include flushing, nausea, headache, shortness of breath and dizziness, resulting from exposure to acetaldehyde, the primary metabolite of ethanol. Long-term, serious health risks have been associated with repeated exposure to acetaldehyde, a carcinogen, among ALDH2-deficient individuals.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Antizol

Condition Name

Condition Name for Antizol
Intervention Trials
Macular Dystrophy, Corneal 1
Acetaldehyde Toxicity 1
Aldehyde Dehydrogenase-2 (ALDH2) Deficiency 1
ALDH2 Deficiency 1
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Condition MeSH

Condition MeSH for Antizol
Intervention Trials
Corneal Dystrophies, Hereditary 1
Stargardt Disease 1
Macular Degeneration 1
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Clinical Trial Locations for Antizol

Trials by Country

Trials by Country for Antizol
Location Trials
United States 3
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Trials by US State

Trials by US State for Antizol
Location Trials
Hawaii 1
California 1
Utah 1
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Clinical Trial Progress for Antizol

Clinical Trial Phase

Clinical Trial Phase for Antizol
Clinical Trial Phase Trials
Phase 2 1
Phase 1 1
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Clinical Trial Status

Clinical Trial Status for Antizol
Clinical Trial Phase Trials
Completed 2
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Clinical Trial Sponsors for Antizol

Sponsor Name

Sponsor Name for Antizol
Sponsor Trials
University of Utah 1
Ted Daley, President 1
Horizon Pharma USA, Inc. 1
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Sponsor Type

Sponsor Type for Antizol
Sponsor Trials
Other 2
Industry 2
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