Patent: 9,695,422
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Summary for Patent: 9,695,422
| Title: | Furin-knockdown bi-functional RNA |
| Abstract: | Compositions and methods to attenuate the immunosuppressive activity of TGF-.beta. through the use of bi-functional shRNAs is described herein. The bi-functional shRNAs of the present invention knocks down the expression of furin in cancer cells to augment tumor antigen expression, presentation, and processing through expression of the GM-CSF transgene. |
| Inventor(s): | Nemunaitis; John J. (Cedar Hill, TX), Senzer; Neil (Delray Beach, FL), Maples; Phillip B. (Pilot Point, TX), Rao; Donald (Dallas, TX) |
| Assignee: | GRADALIS, INC. (Dallas, TX) |
| Application Number: | 14/844,912 |
| Patent Claims: | see list of patent claims |
Details for Patent 9,695,422
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | For Injection | 103132 | 06/04/1986 | ⤷ Try a Trial | 2029-12-23 |
| Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | For Injection | 103132 | ⤷ Try a Trial | 2029-12-23 | |
| Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | Injection | 103132 | ⤷ Try a Trial | 2029-12-23 | |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
