Patent: 9,677,087
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Summary for Patent: 9,677,087
Title: | Vectors and methods for long-term immune evasion to prolong tranplant viability |
Abstract: | A method can include making one or more compositions for altering allogeneic cells of a human donor for a human recipient by identifying at least one mismatch in an HLA protein between the human donor and the human recipient; determining a consensus conserved nucleic acid sequence among nucleic acid sequences encoding a domain having the mismatch or among domains having a plurality of mismatches; and forming at least one of the one or more compositions by constructing a virus vector for expressing a sequence targeting the consensus conserved nucleic acid sequence, which when expressed in cells functions as a negative modulator for nucleic acid encoding the domain having the mismatch or the domains having the plurality of mismatches. |
Inventor(s): | Cicciarelli; James C. (Rolling Hills, CA), Kasahara; Noriyuki (Los Angeles, CA), Logg; Christopher R. (South Pasedena, CA) |
Assignee: | NATIONAL INSTITUTE OF TRANSPLANTATION FOUNDATION (Los Angeles, CA) |
Application Number: | 13/567,064 |
Patent Litigation and PTAB cases: | See patent lawsuits and PTAB cases for patent 9,677,087 |
Patent Claims: | see list of patent claims |
Details for Patent 9,677,087
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Smith & Nephew, Inc. | SANTYL | collagenase | Ointment | 101995 | 06/04/1965 | ⤷ Try a Trial | 2024-05-18 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |