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Last Updated: April 19, 2024

Patent: 9,310,379

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Summary for Patent: 9,310,379

Title:	Methods of crystallizing antibodies
Abstract:	This invention relates to crystals of whole antibodies and fragments thereof, and formulations and compositions comprising such crystals. More particularly, methods are provided for the crystallization of high concentrations of whole antibodies, and fragments thereof, in large batches, and for the preparation of stabilized whole antibody crystals for use alone, or in dry or slurry formulations or compositions. This invention also relates to methods for stabilization, storage and delivery of biologically active whole antibody crystals. The present invention further relates to methods using whole antibody crystals, antibody fragment crystals, or compositions or formulations comprising such crystals for biomedical applications, including biological delivery to humans and animals. More particularly, whole antibody crystals or antibody fragment crystals, or crystal compositions or formulations thereof, are used as a carrier-free delivery system which can slowly release active whole antibodies or fragments thereof, to a subject, where and when they are needed.
Inventor(s):	Shenoy; Bhami (Woburn, MA), Govardhan; Chandrika P. (Lexington, MA), Yang; Mark X. (Newton, MA), Margolin; Alexey L. (Newton, MA)
Assignee:	Ajinomoto Althea, Inc. (San Diego, CA)
Application Number:	12/237,917
Patent Claims:	see list of patent claims

Details for Patent 9,310,379

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>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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