Patent: 9,260,494
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Summary for Patent: 9,260,494
| Title: | Biological active proteins having increased in vivo and/or in vitro stability |
| Abstract: | Increased in vivo and/or in vitro stability is imparted to a biologically active protein by fusing to an amino acid sequence consisting of at least about 100 amino acid residues, which consist essentially of Alanine, Serine and Proline, which form a random coil conformation. Specific examples are described. Also described are related nucleic acids, vectors and cells encoding such amino acids; compositions of biologically active proteins fused to a random coil domain, and methods of making and using the compounds and compositions of the invention. |
| Inventor(s): | Skerra; Arne (Freising, DE), Theobald; Ina (Landshut, DE), Schlapschy; Martin (Freising, DE) |
| Assignee: | Technische Universitat Munchen (Munich, DE) |
| Application Number: | 13/963,953 |
| Patent Claims: | see list of patent claims |
Details for Patent 9,260,494
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Chiesi Usa, Inc. | RETAVASE | reteplase | For Injection | 103786 | 10/30/1996 | ⤷ Try a Trial | 2027-06-21 |
| Swedish Orphan Biovitrum Ab (publ) | KINERET | anakinra | Injection | 103950 | 11/14/2001 | ⤷ Try a Trial | 2027-06-21 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
