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Last Updated: April 23, 2024

Patent: 9,133,495

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Summary for Patent: 9,133,495

Title:	Hybrid suppressor tRNA for vertebrate cells
Abstract:	This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA\'s, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA\'s/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided. The present invention provides vertebrate cells with translation components, e.g., pairs of orthogonal aminoacyl-tRNA synthetases (O-RSs) and orthogonal tRNA\'s (O-tRNA\'s) and individual components thereof, that are used in vertebrate protein biosynthetic machinery to incorporate an unnatural amino acid in a growing polypeptide chain, in a vertebrate cell.
Inventor(s):	Tian; Feng (San Diego, CA), Norman; Thea (San Diego, CA), Chu; Stephanie (San Diego, CA)
Assignee:	Ambrx, Inc. (La Jolla, CA)
Application Number:	12/440,015
Patent Claims:	see list of patent claims

Details for Patent 9,133,495

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Eli Lilly And Company	HUMULIN R U-100	insulin human	Injection	018780	10/28/1982	⤷ Try a Trial	2026-09-08
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Eli Lilly And Company	HUMULIN R U-100	insulin human	Injection	018780	08/06/1998	⤷ Try a Trial	2026-09-08
Eli Lilly And Company	HUMULIN R U-500	insulin human	Injection	018780	03/31/1994	⤷ Try a Trial	2026-09-08
Eli Lilly And Company	HUMULIN R U-100	insulin human	Injection	018780	05/25/2018	⤷ Try a Trial	2026-09-08
Microbix Biosystems Inc.	KINLYTIC	urokinase	For Injection	021846	01/16/1978	⤷ Try a Trial	2026-09-08
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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