Patent: 8,993,721
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Summary for Patent: 8,993,721
Title: | Peptides for targeting apoptotic cells and uses thereof |
Abstract: | Described herein is an isolated polypeptide which is capable of specifically targeting apoptotic cells undergoing apoptosis and consists of the sequence (I): Cys-X.sub.1-Val-Ala-Pro-X.sub.2 (I), wherein X.sub.1 is an amino acid with polar uncharged side chain and X.sub.2 is an amino acid with positive charged side chain. The isolated polypeptide of the present invention may be useful for detecting apoptotic cells, as well as detecting and imaging apoptotic cells in tumor tissue, apoptotic myocardial cells in myocardial infarction tissue, apoptotic nerve cells in stroke tissue, and arteriosclerosis site; the polypeptide is useful for targeted drug delivery thereto. |
Inventor(s): | Lee; Byung Heon (Daegu, KR), Kim; In San (Daegu, KR) |
Assignee: | Kyungpook National University Industry-Academic Cooperation Foundation (N/A) |
Application Number: | 13/467,689 |
Patent Claims: | see list of patent claims |
Details for Patent 8,993,721
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Microbix Biosystems Inc. | KINLYTIC | urokinase | For Injection | 021846 | 01/16/1978 | ⤷ Try a Trial | 2028-05-14 |
Genentech, Inc. | ACTIVASE | alteplase | For Injection | 103172 | 11/13/1987 | ⤷ Try a Trial | 2028-05-14 |
Genentech, Inc. | CATHFLO ACTIVASE | alteplase | For Injection | 103172 | 09/04/2001 | ⤷ Try a Trial | 2028-05-14 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |