Patent: 8,525,104
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Summary for Patent: 8,525,104
| Title: | Methods for direct biomolecule identification by matrix-assisted laser desorption ionization (MALDI) mass spectrometry |
| Abstract: | The present invention relates to the use of post source decay (PSD) or collision induced dissociation (CID) direct tissue (DT) MALDI-TOF or DT-MALDI-TOF-TOF mass spectrographic identification of biological molecules in a tissue or cellular sample without the need for further protein extraction. This method provides for studying cells or tissues by direct tissue MALDI (DT-MALDI), thereby substituting in situ protein release for further protein extraction. Mass/intensity data was processed with Mascot.COPYRGT. software interrogation of the NCBI database. These results are proof of principle that DT-MALDI, combined with bioinformatics, can directly identify proteins in cells and tissues from their mass spectra. |
| Inventor(s): | Pevsner; Paul (New York, NY), Naftolin; Frederick (Woodbridge, CT), Miller; Douglas C. (Belle Mead, NJ), Hillman; Dean (New Hyde Park, NY), Stall; Brian K. (Bedford, NH), Wishnies; Steven M. (Columbia, MD) |
| Assignee: | New York University (New York, NY) |
| Application Number: | 12/799,576 |
| Patent Claims: | see list of patent claims |
Details for Patent 8,525,104
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Smith & Nephew, Inc. | SANTYL | collagenase | Ointment | 101995 | 06/04/1965 | ⤷ Try a Trial | 2025-09-30 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
