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Last Updated: March 28, 2024

Patent: 8,247,397


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Summary for Patent: 8,247,397
Title:Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
Abstract: Combinations of PI3K inhibitor compounds having Formulas I and II and chemotherapeutic agents, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for treating hyperproliferative disorders such as cancer. Methods of using such combinations for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed. ##STR00001##
Inventor(s): Belvin; Marcia (South San Francisco, CA), Friedman; Lori (South San Francisco, CA), Hoeflich; Klaus (San Mateo, CA), Sampath; Deepak (San Francisco, CA), Vijapurkar; Ulka (Millbrae, CA), Wallin; Jeffrey (Berkeley, CA), Johnson; Leisa (Point Richmond, CA), Singh; Mallika (San Francisco, CA), Patel; Sonal (Slough, GB)
Assignee: Genentech, Inc. (South San Francisco, CA) F. Hoffman-La Roche AG (Basel, CH)
Application Number:12/208,227
Patent Claims:see list of patent claims

Details for Patent 8,247,397

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 09/25/1998 ⤷  Try a Trial 2039-02-26
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 02/10/2017 ⤷  Try a Trial 2039-02-26
Genentech, Inc. AVASTIN bevacizumab Injection 125085 02/26/2004 ⤷  Try a Trial 2039-02-26
Genentech, Inc. PERJETA pertuzumab Injection 125409 06/08/2012 ⤷  Try a Trial 2039-02-26
Genentech, Inc. HERCEPTIN HYLECTA trastuzumab and hyaluronidase-oysk Injection 761106 02/28/2019 ⤷  Try a Trial 2039-02-26
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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