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Last Updated: April 18, 2024

Patent: 6,548,735

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Summary for Patent: 6,548,735

Title:	Production of heterologous protein in milk of transgenic non-human mammals comprising a construct with an intron
Abstract:	Proteinaceous products can be produced by transgenic animals having genetic constructs integrated into their genome. The construct comprises a 5\'-flanking sequence from a mammalian milk protein gene (such as beta-lactoglobulin) and DNA coding for a heterologous protein other than the milk protein (for example a serin protease such as alpha.sub.1 -antitrypsin or a blood factor such as Factor VIII or IX). The protein-coding DNA comprises at least one, but not all, of the introns naturally occurring in a gene coding for the heterologous protein. The 5\'-flanking sequence is sufficient to drive expression of the heterologous protein.
Inventor(s):	Archibald; Alan Langskill (Edinburgh, GB), Clark; Anthony John (Midlothian, GB)
Assignee:	PPL (Holdings) Limited (London, GB)
Application Number:	08/781,518
Patent Claims:	see list of patent claims

Details for Patent 6,548,735

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	⤷ Try a Trial	2008-11-11
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		⤷ Try a Trial	2008-11-11
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		⤷ Try a Trial	2008-11-11
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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