Patent: 6,541,450
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Summary for Patent: 6,541,450
Title: | Parathyroid hormone analogues for the treatment of osteoporosis |
Abstract: | This invention describes analogues of human parathyroid hormone which have increased activities in bone restoration, and increased bioavailability. The peptides described are derivatives of hPTH-(1-31) which are cyclized for example, by formation of lactams between either Glu.sup.22 and Lys.sup.26 or Lys.sup.26 and Asp.sup.30. In addition, the natural Lys.sup.27 may be substituted by either a Leu or other hydrophobic residues, such as Ile, norleucine, Met, Val, Ala, Trp, or Phe. Typically, these analogues have enhanced abilities to stimulate adenylyl cyclase in rat osteosarcoma cells, and show increased activities in bone restoration, using the ovariectomized rat model. The analogues also show enhanced activities and bioavailabilities, as demonstrated by their hypotensive effects in the rat. An assay which correlates hypotensive activity with osteogenic activity is also described. |
Inventor(s): | Barbier; Jean-Rene (Gatineau, CA), Morley; Paul (Ottawa, CA), Neugebauer; Witold (Ottawa, CA), Whitfield; James F. (Ottawa, CA), Willick; Gordon E. (Orleans, CA) |
Assignee: | National Research Council of Canada (Ontario, CA) |
Application Number: | 09/536,785 |
Patent Claims: | see list of patent claims |
Details for Patent 6,541,450
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Nps Pharmaceuticals, Inc. | NATPARA | parathyroid hormone | For Injection | 125511 | 01/23/2015 | ⤷ Try a Trial | 2014-06-20 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |